日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Effective extracellular payload release and immunomodulatory interactions govern the therapeutic effect of trastuzumab deruxtecan (T-DXd)

有效的细胞外有效载荷释放和免疫调节相互作用决定了曲妥珠单抗德鲁替康(T-DXd)的治疗效果。

Li-Chung Tsao ,John S Wang ,Xingru Ma ,Sirajbir Sodhi ,Joey V Ragusa ,Bushangqing Liu ,Jason McBane ,Tao Wang ,Junping Wei ,Cong-Xiao Liu ,Xiao Yang ,Gangjun Lei ,Ivan Spasojevic ,Ping Fan ,Timothy N Trotter ,Michael Morse ,Herbert Kim Lyerly ,Zachary C Hartman

Overcoming Xenoantigen Immunity to Enable Cellular Tracking and Gene Regulation with Immune-competent "NoGlow" Mice

克服异种抗原免疫,利用具有免疫能力的“NoGlow”小鼠实现细胞追踪和基因调控

Timothy N Trotter, Andrea Wilson, Jason McBane, Carina E Dagotto, Xiao-Yi Yang, Jun-Ping Wei, Gangjun Lei, Hannah Thrash, Joshua C Snyder, Herbert Kim Lyerly, Zachary C Hartman

Vaccination Against Androgen Receptor Splice Variants to Immunologically Target Prostate Cancer

针对雄激素受体剪接变体的疫苗接种可免疫靶向前列腺癌

Robert D Marek, Selena Halabi, Mu-En Wang, Jason McBane, Junping Wei, Tao Wang, Xiao Yang, Congxiao Liu, Gangjun Lei, Herbert Kim Lyerly, Ming Chen, Timothy N Trotter, Zachary C Hartman

Vaccines targeting ESR1 activating mutations elicit anti-tumor immune responses and suppress estrogen signaling in therapy resistant ER+ breast cancer

针对 ESR1 激活突变的疫苗可引发抗肿瘤免疫反应并抑制对治疗有抵抗力的 ER+ 乳腺癌中的雌激素信号传导

Gabrielle P Dailey, Christopher A Rabiola, Gangjun Lei, Junping Wei, Xiao-Yi Yang, Tao Wang, Cong-Xiao Liu, Melissa Gajda, Amy C Hobeika, Amanda Summers, Robert D Marek, Michael A Morse, Herbert K Lyerly, Erika J Crosby, Zachary C Hartman

Dormant tumors circumvent tumor-specific adaptive immunity by establishing a Treg-dominated niche via DKK3

休眠肿瘤通过 DKK3 建立以 Treg 为主导的微环境来规避肿瘤特异性适应性免疫

Timothy N Trotter, Carina E Dagotto, Delila Serra, Tao Wang, Xiao Yang, Chaitanya R Acharya, Junping Wei, Gangjun Lei, H Kim Lyerly, Zachary C Hartman

Sensitizing immune unresponsive colorectal cancers to immune checkpoint inhibitors through MAVS overexpression

通过MAVS过表达使免疫无反应性结直肠癌对免疫检查点抑制剂敏感

Bin-Jin Hwang ,Li-Chung Tsao ,Chaitanya R Acharya ,Timothy Trotter ,Pankaj Agarwal ,Junping Wei ,Tao Wang ,Xiao-Yi Yang ,Gangjun Lei ,Takuya Osada ,Herbert Kim Lyerly ,Michael A Morse ,Zachary Conrad Hartman

Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis

曲妥珠单抗/帕妥珠单抗联合疗法通过补体依赖性细胞毒性和吞噬作用刺激抗肿瘤反应。

Li-Chung Tsao ,Erika J Crosby ,Timothy N Trotter ,Junping Wei ,Tao Wang ,Xiao Yang ,Amanda N Summers ,Gangjun Lei ,Christopher A Rabiola ,Lewis A Chodosh ,William J Muller ,Herbert Kim Lyerly ,Zachary C Hartman

IL26, a Noncanonical Mediator of DNA Inflammatory Stimulation, Promotes TNBC Engraftment and Progression in Association with Neutrophils

IL26 是一种非典型 DNA 炎症刺激介质,与中性粒细胞一起促进 TNBC 植入和进展

Timothy N Trotter #, Casey W Shuptrine #, Li-Chung Tsao, Robert D Marek, Chaitanya Acharya, Jun-Ping Wei, Xiao-Yi Yang, Gangjun Lei, Tao Wang, Herbert Kim Lyerly, Zachary C Hartman

Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer

通过联合疫苗和 αPD-1 刺激致癌基因特异性肿瘤浸润 T 细胞,实现对已确诊的 HER2 乳腺癌的持续抗肿瘤反应

Erika J Crosby, Chaitanya R Acharya, Anthony-Fayez Haddad, Christopher A Rabiola, Gangjun Lei, Jun-Ping Wei, Xiao-Yi Yang, Tao Wang, Cong-Xiao Liu, Kay U Wagner, William J Muller, Lewis A Chodosh, Gloria Broadwater, Terry Hyslop, Jonathan H Shepherd, Daniel P Hollern, Xiaping He, Charles M Perou, Sh

CD47 blockade augmentation of trastuzumab antitumor efficacy dependent on antibody-dependent cellular phagocytosis

CD47阻断增强曲妥珠单抗抗肿瘤疗效依赖于抗体依赖性细胞吞噬作用

Li-Chung Tsao ,Erika J Crosby ,Timothy N Trotter ,Pankaj Agarwal ,Bin-Jin Hwang ,Chaitanya Acharya ,Casey W Shuptrine ,Tao Wang ,Junping Wei ,Xiao Yang ,Gangjun Lei ,Cong-Xiao Liu ,Christopher A Rabiola ,Lewis A Chodosh ,William J Muller ,Herbert Kim Lyerly ,Zachary C Hartman