Gaofeng Fan相关文献与解析，生知库 | 链接生命科学的每一步

NAMPT-targeting PROTAC and nicotinic acid co-administration elicit safe and robust anti-tumor efficacy in NAPRT-deficient pan-cancers

靶向 NAMPT 的 PROTAC 与烟酸联合给药可在 NAPRT 缺陷型泛癌中发挥安全、强大的抗肿瘤功效

doi:10.1016/j.chembiol.2024.05.007

Xiaotong Zhu, Ye Li, Haixia Liu, Yuetong Wang, Renhong Sun, Zhenzhou Jiang, Chun Hou, Xianyu Hou, Suming Huang, Huijuan Zhang, Haopeng Wang, Biao Jiang, Xiaobao Yang, Bin Xu, Gaofeng Fan

肿瘤

发表日期：2024

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Discovery of Trametinib as an orchestrator for cytoskeletal vimentin remodeling

发现曲美替尼作为细胞骨架波形蛋白重塑的协调剂

期刊:Journal of Molecular Cell Biology

影响因子:5.3

doi:10.1093/jmcb/mjae009

Shuangshuang Zhao, Zhifang Li, Qian Zhang, Yue Zhang, Jiali Zhang, Gaofeng Fan, Xiaobao Cao, Yaming Jiu

Effects of Acmella radicans Invasion on Soil Seed Bank Community Characteristics in Different Habitats

金钮扣入侵对不同生境土壤种子库群落特征的影响

期刊:Plants-Basel

影响因子:4.1

doi:10.3390/plants13182644

Wu, Xiaohan; Yang, Kexin; Zheng, Fengping; Xu, Gaofeng; Fan, Zewen; Clements, David Roy; Yang, Yunhai; Yang, Shaosong; Jin, Guimei; Zhang, Fudou; Shen, Shicai

发表日期：2024

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Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness

调节嵌合抗原受体的电荷密度可优化持续信号传导和CAR-T细胞的适应性

期刊:Cellular Signalling

影响因子:28.1

doi:10.1038/s41422-023-00789-0

Jian Chen # ，Shizhen Qiu # ，Wentao Li # ，Kun Wang ，Yu Zhang ，Han Yang ，Baichuan Liu ，Guangfei Li ，Li Li ，Min Chen ，Junjie Lan ，Jiahua Niu ，Peijie He ，Lei Cheng ，Gaofeng Fan ，Xin Liu ，Xianmin Song ，Chenqi Xu ，Haitao Wu ，Haopeng Wang

Development of the nonreceptor tyrosine kinase FER-targeting PROTACs as a potential strategy for antagonizing ovarian cancer cell motility and invasiveness

开发非受体酪氨酸激酶 FER 靶向 PROTAC 作为拮抗卵巢癌细胞迁移和侵袭性的潜在策略

期刊:Journal of Biological Chemistry

影响因子:4

doi:10.1016/j.jbc.2023.104825

Yanchun Zhang, Xuexue Xiong, Renhong Sun, Xiaotong Zhu, Chen Wang, Biao Jiang, Xiaobao Yang, Dake Li, Gaofeng Fan

Induction of senescence-associated secretory phenotype underlies the therapeutic efficacy of PRC2 inhibition in cancer

诱导衰老相关分泌表型是 PRC2 抑制对癌症治疗效果的基础

期刊:Cell Death & Disease

影响因子:8.1

doi:10.1038/s41419-022-04601-6

Liping Chu #, Yuxiu Qu #, Yang An #, Linjun Hou, Juewan Li, Weijia Li, Gaofeng Fan, Bao-Liang Song, En Li, Liye Zhang, Wei Qi

Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation

通过 PROTAC 介导的降解解决 NAMPT 的酶非依赖性肿瘤促进功能

期刊:Cell Chemical Biology

影响因子:6.6

doi:10.1016/j.chembiol.2022.10.007

Xiaotong Zhu, Haixia Liu, Li Chen, Chenxu Wu, Xuesong Liu, Yong Cang, Biao Jiang, Xiaobao Yang, Gaofeng Fan

Visible light-responsive hydrogels for cellular dynamics and spatiotemporal viscoelastic regulation

可见光响应水凝胶用于细胞动力学和时空粘弹性调节

Minimizing DNA trapping while maintaining activity inhibition via selective PARP1 degrader

通过选择性PARP1降解剂最大限度地减少DNA捕获，同时保持活性抑制

PINX1 loss confers susceptibility to PARP inhibition in pan-cancer cells

PINX1 缺失使泛癌细胞对 PARP 抑制更敏感

NAMPT-targeting PROTAC and nicotinic acid co-administration elicit safe and robust anti-tumor efficacy in NAPRT-deficient pan-cancers

靶向 NAMPT 的 PROTAC 与烟酸联合给药可在 NAPRT 缺陷型泛癌中发挥安全、强大的抗肿瘤功效

Discovery of Trametinib as an orchestrator for cytoskeletal vimentin remodeling

发现曲美替尼作为细胞骨架波形蛋白重塑的协调剂

Effects of Acmella radicans Invasion on Soil Seed Bank Community Characteristics in Different Habitats

金钮扣入侵对不同生境土壤种子库群落特征的影响

Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness

调节嵌合抗原受体的电荷密度可优化持续信号传导和CAR-T细胞的适应性

Development of the nonreceptor tyrosine kinase FER-targeting PROTACs as a potential strategy for antagonizing ovarian cancer cell motility and invasiveness

开发非受体酪氨酸激酶 FER 靶向 PROTAC 作为拮抗卵巢癌细胞迁移和侵袭性的潜在策略

Induction of senescence-associated secretory phenotype underlies the therapeutic efficacy of PRC2 inhibition in cancer

诱导衰老相关分泌表型是 PRC2 抑制对癌症治疗效果的基础

Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation

通过 PROTAC 介导的降解解决 NAMPT 的酶非依赖性肿瘤促进功能