日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Critical role for a high-plasticity cell state in lung cancer

高可塑性细胞状态在肺癌中的关键作用

Jason E Chan #,Chun-Hao Pan #,Jonathan Rub,Gary Guzman,Klavdija Krause,Emma Brown,Zeda Zhang,Hannah Styers,Griffin Hartmann,Zhuxuan Li,Xueqian Zhuang,Scott W Lowe,Doron Betel,Yan Yan,Tuomas Tammela

RAF-independent MEK mutations drive refractory histiocytic neoplasms but respond to ERK inhibition

RAF非依赖性MEK突变驱动难治性组织细胞肿瘤,但对ERK抑制剂有反应。

Eli L Diamond,Jean-Francois Emile,Takeshi Fujino,Julien Haroche,Maxim I Maron,Alexander M Lewis,Jahan Rahman,Anne S Reiner,Dana Bossert,Marc Rosenblum,Mariko Yabe,Kseniya Petrova-Drus,Jasmine H Francis,Veronica Rotemberg,Raajit K Rampal,Sarah Yoo,Anthony F Daniyan,Sonia Mahajan,Vaios Hatzoglou,Robert Young,Gary A Ulaner,Wiebke Rösler,Oshrat Hershkovitz-Rokah,Ofer Shpilberg,Roei D Mazor,Luke Y C Chen,Michael Singer,M Adriana Cuibus,Kenyon Weis,Salima Benbarche,Pu Zhang,Nina Fox,Cynthia Castro,Steven Tittley,Matthew Witkowski,Fleur Cohen-Aubart,Louis Terriou,Maher Hanoun,Nicolas Schleinitz,Gabriela Sosa,Timo Hautala,Laure Farnault De Lassus,Neal Rosen,Omar Abdel-Wahab,Benjamin H Durham

Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency.

线粒体铁氧还蛋白 FDX2 的突变可抑制弗拉塔辛缺乏症。

Meisel Joshua D, Joshi Pallavi R, Spelbring Amy N, Wang Hong, Wellner Sandra M, Wiesenthal Presli P, Miranda Maria, McCoy Jason G, Barondeau David P, Ruvkun Gary, Mootha Vamsi K

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.

利用 iPSC 衍生神经元进行 CRISPR 筛选揭示了 tau 蛋白稳态的原理。

Samelson Avi J, Ariqat Nabeela, McKetney Justin, Rohanitazangi Gita, Parra Bravo Celeste, Bose Rudra S, Travaglini Kyle J, Lam Victor L, Goodness Darrin, Ta Thomas, Dixon Gary, Marzette Emily, Jin Julianne, Tian Ruilin, Tse Eric, Abskharon Romany, Pan Henry S, Carroll Emma C, Lawrence Rosalie E, Gestwicki Jason E, Rexach Jessica E, Eisenberg David S, Kanaan Nicholas M, Southworth Daniel R, Gross John D, Gan Li, Swaney Danielle L, Kampmann Martin

Pivekimab Sunirine in Blastic Plasmacytoid Dendritic Cell Neoplasm

Pivekimab Sunirine 治疗浆细胞样树突状细胞肿瘤

Pemmaraju, Naveen; Marconi, Giovanni; Montesinos, Pau; Lane, Andrew A; Mazzarella, Luca; Sallman, David A; Ulrickson, Matthew L; Schiller, Gary J; Erba, Harry P; Wang, Eunice S; Walter, Roland B; Deconinck, Eric; Aribi, Ahmed; Legrand, Ollivier; Lebon, Delphine; Maisano, Valerio; Martinelli, Giovanni; DeAngelo, Daniel J; Derenzini, Enrico; Du, Yining; Lakshmikanthan, Sribalaji; Potluri, Jalaja; Kantarjian, Hagop M; Daver, Naval G

Improved polygenic risk prediction models for breast cancer subtypes in women of African ancestry

改进的针对非洲裔女性乳腺癌亚型的多基因风险预测模型

Li, James L; Zhang, Haoyu; Wang, Xiaoyu; Jia, Guochong; McClellan, Julian C; Guo, Wenji; Sun, Yijia; Fiorica, Peter N; Ambs, Stefan; Barnard, Mollie E; Chen, Yu; Garcia-Closas, Montserrat; Gu, Jian; Hu, Jennifer J; John, Esther M; Nathanson, Katherine L; Nemesure, Barbara; Pal, Tuya; Shu, Xiao-Ou; Press, Michael F; Sanderson, Maureen; Sandler, Dale P; Troester, Melissa A; Yao, Song; Long, Jirong; Ahearn, Thomas U; Brewster, Abenaa M; Falusi, Adeyinka; Kraft, Peter; Hennis, Anselm J M; Makumbi, Timothy; Mapoko, Berthe S E; O'Brien, Katie M; Ojengbede, Oladosu; Olshan, Andrew F; Reid, Sonya; Zirpoli, Gary; Cai, Qiuyin; Butler, Eboneé N; Huang, Maosheng; Obafunwa, John; Weinberg, Clarice R; Ambrosone, Christine; Ping, Jie; Tao, Ran; Li, Bingshan; Guo, Xingyi; Gao, Guimin; Conti, David V; Chatterjee, Nilanjan; Palmer, Julie R; Olopade, Olufunmilayo I; Zheng, Wei; Haiman, Christopher A; Huo, Dezheng

C/EBPβ-induced alternative splicing of RCAN1 generates a potent TCR-T target in mesenchymal glioblastoma.

C/EBPβ诱导的RCAN1选择性剪接在间充质胶质母细胞瘤中产生有效的TCR-T靶点。

Xiong Zujian, Kong Qinglin, Chagantipati Bhuvitha, Stepniak Amelia, Jaswal Ambika P, Sneiderman Chaim T, Han Yuanyuan, Jackson Sydney A, Raphael Rebecca A, Zhang Wei, Li Muzi, Chao Yapeng, Qin Bin, Dulkadir Zeynep, Schwegman Lance, Zhang Yihao, Kuminkoski Chloe, Mahlke Megan A, Nath Poulomi, Hu Baoli, Zinn Pascal O, Mantica Megan, Agnihotri Sameer, Nechemia-Arbely Yael, Pollack Ian F, Rigatti Lora H, Forsthuber Thomas G, Li Xuejun, Raphael Itay, Kohanbash Gary

Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome

肺癌和卵巢癌对铂类化疗的耐药性是由可靶向的TGFβ衰老分泌组驱动的。

González-Gualda, Estela; Reinius, Marika A V; Macias, David; Morsli, Samir; Ge, Jianfeng; Olan, Ioana; Martín, José Ezequiel; Ou, Hui-Ling; Hartono, Muhamad; Puerto-Camacho, María Pilar; Denholm, Mary; Kieran, Rosalind; Hoffmann, Reuben; Dane, Mark; Veroutis, Dimitris; Medrano, Guillermo; Mulero, Francisca; Jimenez-Linan, Mercedes; Fruk, Ljiljana; Martins, Carla P; Barbacid, Mariano; Gorgoulis, Vassilis; Korkola, James E; Rassl, Doris M; Doherty, Gary J; Rintoul, Robert C; Narita, Masashi; Brenton, James D; Muñoz-Espín, Daniel

Evolution of Firearm Mortality as the Leading Cause of Death in the US Pediatric Population

枪支致死率成为美国儿童死亡首要原因的演变

Nance, Michael L; Croughan, Allie M; Allukian, Myron 3rd; Hwang, Rosa; Krumbhaar, Camryn J; Nace, Gary W Jr

Deep-Learning Tool ScVital Enables Species-Agnostic Integration of Cancer Cell States

深度学习工具 ScVital 实现了与物种无关的癌细胞状态整合

Rub, Jonathan; Chan, Jason E; Sussman, Carleigh; Guzman, Gary; Tap, William D; Antonescu, Cristina R; Singer, Samuel; Tammela, Tuomas; Betel, Doron