日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptor.

二氢噻唑并吡啶酮衍生物作为代谢型谷氨酸 5 (mGlu5) 受体的一类新型正向变构调节剂

Bartolomé-Nebreda José Manuel, Conde-Ceide Susana, Delgado Francisca, Iturrino Laura, Pastor Joaquín, Pena Miguel Ángel, Trabanco Andrés A, Tresadern Gary, Wassvik Carola M, Stauffer Shaun R, Jadhav Satyawan, Gogi Kiran, Vinson Paige N, Noetzel Meredith J, Days Emily, Weaver C David, Lindsley Craig W, Niswender Colleen M, Jones Carrie K, Conn P Jeffrey, Rombouts Frederik, Lavreysen Hilde, Macdonald Gregor J, Mackie Claire, Steckler Thomas

Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM

开发了一种新型的、可穿透中枢神经系统的代谢型谷氨酸受体3 (mGlu3) NAM探针 (ML289),该探针源自一种密切相关的mGlu5 PAM。

Sheffler, Douglas J; Wenthur, Cody J; Bruner, Joshua A; Carrington, Sheridan J S; Vinson, Paige N; Gogi, Kiran K; Blobaum, Anna L; Morrison, Ryan D; Vamos, Mitchell; Cosford, Nicholas D P; Stauffer, Shaun R; Daniels, J Scott; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W

Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of MPEP-site interaction crossover

mGlu5正变构调节剂醚系列的优化:MPEP位点相互作用交叉的分子决定因素

Manka, Jason T; Vinson, Paige N; Gregory, Karen J; Zhou, Ya; Williams, Richard; Gogi, Kiran; Days, Emily; Jadhav, Satya; Herman, Elizabeth J; Lavreysen, Hilde; Mackie, Claire; Bartolomé, José M; Macdonald, Gregor J; Steckler, Thomas; Daniels, J Scott; Weaver, C David; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Lindsley, Craig W; Stauffer, Shaun R