日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A First-in-Class High-Throughput Screen to Discover Modulators of the Alternative Lengthening of Telomeres (ALT) Pathway.

首创高通量筛选方法,用于发现端粒替代延长(ALT)途径的调节剂

Froney Merrill M, Cook Christian R, Cadiz Alyssa M, Flinter Katherine A, Ledeboer Sara T, Chan Bianca, Burris Lauren E, Hardy Brian P, Pearce Kenneth H, Wardell Alexis C, Golitz Brian T, Jarstfer Michael B, Pattenden Samantha G

Neratinib, a pan ERBB/HER inhibitor, restores sensitivity of PTEN-null, BRAFV600E melanoma to BRAF/MEK inhibition

Neratinib 是一种泛 ERBB/HER 抑制剂,可恢复 PTEN 基因缺失的 BRAFV600E 黑色素瘤对 BRAF/MEK 抑制的敏感性

Evan DuBose #, Samantha M Bevill #, Dana K Mitchell, Noah Sciaky, Brian T Golitz, Shelley A H Dixon, Steven D Rhodes, James E Bear, Gary L Johnson, Steven P Angus

Kinome state is predictive of cell viability in pancreatic cancer tumor and cancer-associated fibroblast cell lines.

激酶组状态可预测胰腺癌肿瘤和癌症相关成纤维细胞系的细胞活力

Berginski Matthew E, Jenner Madison R, Joisa Chinmaya U, Herrera Loeza Gabriela, Golitz Brian T, Lipner Matthew B, Leary Jack R, Rashid Naim, Johnson Gary L, Yeh Jen Jen, Gomez Shawn M

Kinome inhibition states and multiomics data enable prediction of cell viability in diverse cancer types

激酶组抑制状态和多组学数据能够预测多种癌症类型的细胞活力

Berginski, Matthew E; Joisa, Chinmaya U; Golitz, Brian T; Gomez, Shawn M

Combined kinome inhibition states are predictive of cancer cell line sensitivity to kinase inhibitor combination therapies

联合激酶组抑制状态可预测癌细胞系对激酶抑制剂联合疗法的敏感性

Chinmaya U Joisa, Kevin A Chen, Samantha Beville, Timothy Stuhlmiller, Matthew E Berginski, Denis Okumu, Brian T Golitz, Gary L Johnson, Shawn M Gomez

Irreversible JNK1-JUN inhibition by JNK-IN-8 sensitizes pancreatic cancer to 5-FU/FOLFOX chemotherapy

JNK-IN-8 对 JNK1-JUN 的不可逆抑制作用可增强胰腺癌对 5-FU/FOLFOX 化疗的敏感性

Matthew B Lipner ,Xianlu L Peng ,Chong Jin ,Yi Xu ,Yanzhe Gao ,Michael P East ,Naim U Rashid ,Richard A Moffitt ,Silvia G Herrera Loeza ,Ashley B Morrison ,Brian T Golitz ,Cyrus Vaziri ,Lee M Graves ,Gary L Johnson ,Jen Jen Yeh

GSK2801, a BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer

GSK2801 是一种 BAZ2/BRD9 溴结构域抑制剂,可与 BET 抑制剂协同作用,诱导三阴性乳腺癌细胞凋亡

Samantha M Bevill, Jose F Olivares-Quintero, Noah Sciaky, Brian T Golitz, Darshan Singh, Adriana S Beltran, Naim U Rashid, Timothy J Stuhlmiller, Andrew Hale, Nathaniel J Moorman, Charlene M Santos, Steven P Angus, Jon S Zawistowski, Gary L Johnson

Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of Gemcitabine-Resistant Pancreatic Cancer Cell Growth

应用综合药物筛选/激酶组分析鉴定吉西他滨耐药胰腺癌细胞生长的抑制剂

Linas J Krulikas, Ian M McDonald, Benjamin Lee, Denis O Okumu, Michael P East, Thomas S K Gilbert, Laura E Herring, Brian T Golitz, Carrow I Wells, Allison D Axtman, William J Zuercher, Timothy M Willson, Dmitri Kireev, Jen Jen Yeh, Gary L Johnson, Antonio T Baines, Lee M Graves

TMIC-25. DISSECTING THE ROLE OF HOST GENETICS IN GLIOMA EVOLUTION USING GENETICALLY-ENGINEERED MOUSE MODELS AND THE COLLABORATIVE CROSS

TMIC-25. 利用基因工程小鼠模型和合作交叉研究剖析宿主遗传学在胶质瘤演化中的作用

Okutman, Ozlem; Rhouma, Maroua Ben; Benkhalifa, Moncef; Muller, Jean; Viville, Stéphane; Skinner, Kasey; Ferris, Martin; Bash, Ryan; Shelton, Abigail; Smithberger, Erin; Angus, Steven; Golitz, Brian; Sciacky, Noah; Simon, Jeremy; Stein, Jason; Matsushima, Glenn; Ostrom, Quinn; Stetson, Lindsay; Barnholtz-Sloan, Jill; Dhruv, Harshil; Berens, Michael; de Villena, Fernando Pardo Manuel; Miller, Ryan

Enhancer Remodeling during Adaptive Bypass to MEK Inhibition Is Attenuated by Pharmacologic Targeting of the P-TEFb Complex

适应性旁路 MEK 抑制过程中的增强子重塑可通过 P-TEFb 复合物的药理靶向作用减弱

Jon S Zawistowski, Samantha M Bevill, Daniel R Goulet, Timothy J Stuhlmiller, Adriana S Beltran, Jose F Olivares-Quintero, Darshan Singh, Noah Sciaky, Joel S Parker, Naim U Rashid, Xin Chen, James S Duncan, Martin C Whittle, Steven P Angus, Sara Hanna Velarde, Brian T Golitz, Xiaping He, Charlene Sa