日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The ubiquitin ligase KLHL6 drives resistance to CD8(+) T cell dysfunction.

泛素连接酶 KLHL6 驱动对 CD8(+) T 细胞功能障碍的抵抗力。

Cheng Hongcheng, Su Yapeng, Pan Xiaoli, Xu Yue, Xie Ermei, Du Jing, Chen Daniel G, Dai Xiaomeng, Gottardo Raphael, Greenberg Philip D, Li Guideng

A phase I/II trial of WT1-specific TCR gene therapy for patients with acute myeloid leukemia and active disease post-allogeneic hematopoietic cell transplantation: skewing towards NK-like phenotype impairs T cell function and persistence

一项针对接受异基因造血干细胞移植后仍处于活动期的急性髓系白血病患者的WT1特异性TCR基因治疗I/II期试验:NK样表型偏向会损害T细胞功能和持久性。

Mazziotta, Francesco; Martin, Lauren E; Egan, Daniel N; Bar, Merav; Kinsella, Sinéad; Paulson, Kelly G; Voillet, Valentin; Lahman, Miranda C; Hunter, Daniel; Schmitt, Thomas M; Duerkopp, Natalie; Yeung, Cecilia C S; Tang, Tzu-Hao; Gottardo, Raphael; Asano, Yuta; Wilcox, Elise C; Lee, Bo; Zhang, Tianzi; Lopedote, Paolo; Penter, Livius; Wu, Catherine J; Milano, Filippo; Greenberg, Philip D; Chapuis, Aude G

ADTnorm: robust integration of single-cell protein measurement across CITE-seq datasets

ADTnorm:跨 CITE-seq 数据集的单细胞蛋白质测量的稳健整合

Zheng, Ye; Caron, Daniel P; Kim, Ju Yeong; Jun, Seong-Hwan; Tian, Yuan; Mair, Florian; Stuart, Kenneth D; Sims, Peter A; Gottardo, Raphael

Transcriptome analysis of archived tumors by Visium, GeoMx DSP, and Chromium reveals patient heterogeneity.

利用 Visium、GeoMx DSP 和 Chromium 对存档肿瘤进行转录组分析,揭示了患者的异质性

Dong Yixing, Saglietti Chiara, Bayard Quentin, Espin Perez Almudena, Carpentier Sabrina, Buszta Daria, Tissot Stephanie, Dubois Rémy, Kamburov Atanas, Kang Senbai, Haignere Carla, Sarkis Rita, Andre Sylvie, Alexandre Gaveta Marina, Lopez Lastra Silvia, Piazzon Nathalie, Santos Rita, von Loga Katharina, Hoffmann Caroline, Coukos George, Peters Solange, Soumelis Vassili, Durand Eric Yves, de Leval Laurence, Gottardo Raphael, Homicsko Krisztian, Madissoon Elo

Triple checkpoint blockade of PD-1, Tim-3, and Lag-3 enhances adoptive T cell immunotherapy in a mouse model of ovarian cancer

在卵巢癌小鼠模型中,PD-1、Tim-3 和 Lag-3 三重检查点阻断可增强过继性 T 细胞免疫疗法的疗效。

Alencar, Gabriel F; Mohamed, Asmaa O; Burnett, Madison G; Jean, Samantha St; Nelson, Anders R; Su, Yapeng; Voillet, Valentin; Bates, Breanna M; Rodgers Suarez, Magdalia; Ruskin, Susan L; Trieu, Lam; Lam, Jennifer L; Bekiranov, Stefan; Gottardo, Raphael; Greenberg, Philip D; Anderson, Kristin G

A TGF-βR/IL-2R immunomodulatory fusion protein transforms immunosuppression into T cell activation to enhance adoptive T cell therapy

TGF-βR/IL-2R免疫调节融合蛋白可将免疫抑制转化为T细胞活化,从而增强过继性T细胞疗法。

Su, Yapeng; Thelen, Ashley; Wirth, Lena V; Jenkins, Cody M; Mak, Sam R; Chen, Daniel G; Gottardo, Raphael; Greenberg, Philip D

Bcl6 expression is associated with a distinct immune landscape and spatial transcriptome in COVID-19

Bcl6表达与COVID-19中独特的免疫微环境和空间转录组相关

Brenna, Cloé; Bramon Mora, Bernat; Ioannidou, Kalliopi; Bodelet, Julien; Siebmanns, Mia L; Burgermeister, Simon; Georgakis, Spiros; Orfanakis, Michail; Muller, Yannick D; Sédille, Nazanin; Feinstein, Matthew J; Lomasney, Jon W; Chén, Oliver Y; Pantaleo, Giuseppe; Berezowska, Sabina; de Leval, Laurence; Gottardo, Raphael; Petrovas, Constantinos

Cellular and molecular determinants mediating the dysregulated germinal center immune dynamics in systemic lupus erythematosus

系统性红斑狼疮中生发中心免疫动力学失调的细胞和分子决定因素

Georgakis, Spiros; Ioannidou, Kalliopi; Mora, Bernat Bramon; Orfanakis, Michail; Brenna, Cloe; Muller, Yannick D; Del Rio Estrada, Perla M; Sharma, Ashish A; Pantaleo, Giuseppe; de Leval, Laurence; Comte, Denis; Gottardo, Raphael; Petrovas, Constantinos

Unsupervised Clustering of Cell Populations in Germinal Centers Using Multiplexed Immunofluorescence.

利用多重免疫荧光技术对生发中心细胞群进行无监督聚类

Burgermeister Simon, Orfanakis Michail, Georgakis Spiros, Brenna Cloe, Lindsay Helen, Fenwick Craig, Pantaleo Giuseppe, Gottardo Raphael, Petrovas Constantinos

tagtango: an application to compare single-cell annotations

tagtango:一款用于比较单细胞注释的应用程序

Bramon Mora, Bernat; Lindsay, Helen; Thiébaut, Antonin; Stuart, Kenneth D; Gottardo, Raphael