日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bidirectional CRISPR screens decode a GLIS3-dependent fibrotic cell circuit.

双向 CRISPR 筛选解码 GLIS3 依赖性纤维化细胞回路。

Pokatayev Vladislav, Jaiswal Alok, Shih Angela R, Segerstolpe à sa, Li Bihua, Creasey Elizabeth A, Zhao Yanhua, Lin Crystal, Murphy Shane, Chou Chih-Hung, Graham Daniel B, Xavier Ramnik J

Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity.

人类遗传学指导着具有抗炎活性的 CARD9 抑制剂的发现。

Rush Jason S, Wertheimer Joshua D, Goldberg Steven D, Raymond Donald, Szuchnicki Mateusz, Baltus Andrew J, Branson Jeff, Stratton Christopher F, Patrick Aaron N, Steele Ruth, Adhikary Suraj, Del Rosario Amanda, Liu Annie, Gomersall Noah J, Chung Michael, Ranaghan Matthew J, Gu Xiebin, Brandt Marta, Cao Zhifang, Bebenek Adrian, Oliver Blayne A, Hoebe Kasper, Szewczuk Lawrence M, Venable Jennifer D, Graham Daniel B, Towne Jennifer, Xavier Ramnik J

Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk

全基因组关联分析揭示了自身免疫性甲状腺功能减退症的自身免疫和甲状腺特异性因素,以及与癌症风险的负相关关系。

Reeve, Mary Pat; Kanai, Masahiro; Graham, Daniel B; Karjalainen, Juha; Luo, Shuang; Kolosov, Nikita; Adams, Cameron; Ritari, Jarmo; Karczewski, Konrad J; Kiiskinen, Tuomo; Jiang, Yu; Fuller, Zachary; Mehtonen, Juha; Kurki, Mitja I; Khan, Zia; Partanen, Jukka; McCarthy, Mark I; Artomov, Mykyta; Palotie, Aarno; Tuomi, Tiinamaija; Pirinen, Matti; Kero, Jukka; Xavier, Ramnik J; Daly, Mark J; Ripatti, Samuli

Mechanisms of inflammatory bowel diseases: Insights from human genetics and chemical biology

炎症性肠病的机制:来自人类遗传学和化学生物学的启示

Graham, Daniel B; Xavier, Ramnik J

Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseases.

空间转录组学揭示了间质性肺疾病中异常上皮细胞和促纤维化成纤维细胞的改变群落和驱动因素。

Jaiswal Alok, Kooistra Tristan, Pokatayev Vladislav, Bastos Hélder N, Santos Rita F, Sarraf Tresa R, Segerstolpe à sa, Lin Crystal, Amir-Zilberstein Liat, Twardus Shaina, Shannon Kevin, Murphy Shane P, Knipe Rachel, Ganzleben Ingo K, Black Katharine E, Delorey Toni M, Graham Daniel B, Hung Yin P, Hariri Lida P, Deguine Jacques, Carvalho Agostinho, Medoff Benjamin D, Xavier Ramnik J

Identifying microbial protease allergens through protein language model-guided homology.

通过蛋白质语言模型指导的同源性鉴定微生物蛋白酶过敏原。

Thurimella Kumar, Wu Elena, Li Chenhao, Graham Daniel B, Owens Róisín M, Plichta Damian R, Sokol Caroline L, Xavier Ramnik J, Bacallado Sergio

Single-cell and spatial transcriptomics of stricturing Crohn's disease highlights a fibrosis-associated network

克罗恩病狭窄型的单细胞和空间转录组学研究揭示了一个与纤维化相关的网络

Kong, Lingjia; Subramanian, Sathish; Segerstolpe, Åsa; Tran, Vy; Shih, Angela R; Carter, Grace T; Kunitake, Hiroko; Twardus, Shaina W; Li, Jasmine; Gandhi, Shivam; Kaper, Marco E; Cauley, Christy; Chen, Eric J; Porter, Caroline B M; Delorey, Toni M; Bordeianou, Liliana; Ricciardi, Rocco; Ananthakrishnan, Ashwin N; Lau, Helena; Graham, Daniel B; Hodin, Richard; Deguine, Jacques; Smillie, Christopher S; Xavier, Ramnik J

Unusual Phospholipids from Morganella morganii Linked to Depression

摩根氏菌中一种不寻常的磷脂与抑郁症有关

Bang, Sunghee; Shin, Yern-Hyerk; Park, Sung-Moo; Deng, Lei; Williamson, R Thomas; Graham, Daniel B; Xavier, Ramnik J; Clardy, Jon

Correction to "Unusual Phospholipids from Morganella morganii Linked to Depression"

关于“摩根氏摩根菌中异常磷脂与抑郁症有关”的更正

Bang, Sunghee; Shin, Yern-Hyerk; Park, Sung-Moo; Deng, Lei; Williamson, R Thomas; Graham, Daniel B; Xavier, Ramnik J; Clardy, Jon

The Ulcerative Colitis-Associated Gene NXPE1 Catalyzes Glycan Modifications on Colonic Mucin.

溃疡性结肠炎相关基因 NXPE1 催化结肠粘蛋白的糖基化修饰

Humeidi Ranad, Oshiro-Rapley Noriko, Gu Xiebin, An Joon Soo, Ananthakrishnan Ashwin N, Creasey Elizabeth A, Daly Mark J, Schreiber Stuart L, Graham Daniel B, Seyedsayamdost Mohammad R, Xavier Ramnik J