日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Retinol Binding Protein 4 reactivates latent HIV-1 by triggering canonical NF-κB, JAK/STAT5 and JNK signalling

视黄醇结合蛋白4通过触发经典的NF-κB、JAK/STAT5和JNK信号通路重新激活潜伏的HIV-1病毒。

Chiara Pastorio #,Khumoekae Richard #,Shariq Usmani #,Ann-Kathrin Kissmann #,Grigory Bolotnikov,Guillermo Gosálbez,Manuel Hayn,Lennart Koepke,Alina Sauertnik,Andrea Preising,Nico Preising,Ludger Ständker,Matthew Fair,Jessicamarie Morris,Emmanouil Papasavvas,Qin Liu,Honghong Sun,Armando Rodríguez,Karam Mounzer,Sebastian Wiese,Pablo Tebas,Yangzhu Du,Gregory M Laird,Markus Jaritz,Frank Rosenau,Moritz M Gaidt,Konstantin M J Sparrer,Luis J Montaner,Frank Kirchhoff

Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts

单细胞分析揭示了影响急性治疗人群中 HIV-1 病毒库大小的单核细胞基因表达谱

Philip K Ehrenberg # ,Aviva Geretz # ,Meta Volcic # ,Taisuke Izumi ,Lauren K Yum ,Adam Waickman ,Shida Shangguan ,Dominic Paquin-Proulx ,Matthew Creegan ,Meera Bose ,Kawthar Machmach ,Aidan McGraw ,Akshara Narahari ,Jeffrey R Currier ,Carlo Sacdalan ,Nittaya Phanuphak ,Richard Apps ,Michael Corley ,Lishomwa C Ndhlovu ,Bonnie Slike ,Shelly J Krebs ,Jintanat Anonworanich ,Sodsai Tovanabutra ,Merlin L Robb ,Michael A Eller ,Gregory M Laird ,Joshua Cyktor ,Eric S Daar ,Trevor A Crowell ,John W Mellors ,Sandhya Vasan ,Nelson L Michael ,Frank Kirchhoff ,Rasmi Thomas

SIV Env RhmAbs + N-803 at ART initiation prolongs viral decay without disrupting reservoir establishment in SIV-infected infant macaques

在抗逆转录病毒治疗开始时使用SIV Env RhmAbs + N-803可延长SIV感染幼猴体内病毒衰减时间,且不会破坏病毒库的建立。

Omotayo Farinre ,Tzoalli Anaya ,Alexis C King ,Kedan Endrias ,Anne H Hébert ,Alison L Hill ,Sherrie Jean ,Jennifer S Wood ,Stephanie Ehnert ,Shan Liang ,Gregory M Laird ,Rosemarie D Mason ,Mario Roederer ,Jeffrey T Safrit ,Maud Mavigner ,Ann Chahroudi

Rapid Biphasic Decay of Intact and Defective HIV DNA Reservoir During Acute Treated HIV Disease

急性 HIV 疾病治疗期间完整和缺陷 HIV DNA 库的快速双相衰变

Alton Barbehenn, Lei Shi, Junzhe Shao, Rebecca Hoh, Heather M Hartig, Vivian Pae, Sannidhi Sarvadhavabhatla, Sophia Donaire, Caroline Sheikhzadeh, Jeffrey Milush, Gregory M Laird, Mignot Mathias, Kristen Ritter, Michael J Peluso, Jeffrey Martin, Frederick Hecht, Christopher Pilcher, Stephanie E Cohe

Single center, open label dose escalating trial evaluating once weekly oral ixazomib in ART-suppressed, HIV positive adults and effects on HIV reservoir size in vivo

单中心、开放标签剂量递增试验,评估 ART 抑制的 HIV 阳性成人每周口服一次伊沙佐米及其对体内 HIV 储存库大小的影响

Nathan W Cummins, Jason Baker, Rana Chakraborty, Patrick G Dean, Enrique Garcia-Rivera, Ashton Krogman, Shaji Kumar, Yury V Kuzmichev, Gregory M Laird, Alan Landay, Mathias Lichterfeld, Maryam Mahmood, Jeffrey Martinson, Mark Maynes, Sekar Natesampillai, Vincent Rajkumar, Yelizaveta Rassadkina, Kris

Similar Frequency and Inducibility of Intact Human Immunodeficiency Virus-1 Proviruses in Blood and Lymph Nodes

完整的人类免疫缺陷病毒-1 前病毒在血液和淋巴结中的出现频率和诱导性相似

Alyssa R Martin, Alexandra M Bender, Jada Hackman, Kyungyoon J Kwon, Briana A Lynch, Daniel Bruno, Craig Martens, Subul Beg, Sander S Florman, Niraj Desai, Dorry Segev, Gregory M Laird, Janet D Siliciano, Thomas C Quinn, Aaron A R Tobian, Christine M Durand, Robert F Siliciano, Andrew D Redd

Distinct viral reservoirs in individuals with spontaneous control of HIV-1

HIV-1 自发控制个体体内存在不同的病毒库

Chenyang Jiang # ,Xiaodong Lian # ,Ce Gao # ,Xiaoming Sun ,Kevin B Einkauf ,Joshua M Chevalier ,Samantha M Y Chen ,Stephane Hua ,Ben Rhee ,Kaylee Chang ,Jane E Blackmer ,Matthew Osborn ,Michael J Peluso ,Rebecca Hoh ,Ma Somsouk ,Jeffrey Milush ,Lynn N Bertagnolli ,Sarah E Sweet ,Joseph A Varriale ,Peter D Burbelo ,Tae-Wook Chun ,Gregory M Laird ,Erik Serrao ,Alan N Engelman ,Mary Carrington ,Robert F Siliciano ,Janet M Siliciano ,Steven G Deeks ,Bruce D Walker ,Mathias Lichterfeld ,Xu G Yu

Differential decay of intact and defective proviral DNA in HIV-1-infected individuals on suppressive antiretroviral therapy

接受抑制性抗逆转录病毒治疗的 HIV-1 感染者中完整和缺陷前病毒 DNA 的差异衰减

Michael J Peluso, Peter Bacchetti, Kristen D Ritter, Subul Beg, Jun Lai, Jeffrey N Martin, Peter W Hunt, Timothy J Henrich, Janet D Siliciano, Robert F Siliciano, Gregory M Laird, Steven G Deeks

Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells

共同机制控制循环 CD103+ 和肠道 CD4+ T 细胞中的 HIV 转录抑制

Steven A Yukl #, Shahzada Khan #, Tsui-Hua Chen, Martin Trapecar, Frank Wu, Guorui Xie, Sushama Telwatte, Daniel Fulop, Alexander R Pico, Gregory M Laird, Kristen D Ritter, Norman G Jones, Chuanyi M Lu, Robert F Siliciano, Nadia R Roan, Jeffrey M Milush, Ma Somsouk, Steven G Deeks, Peter W Hunt, Sho

Transcriptional Reprogramming during Effector-to-Memory Transition Renders CD4+ T Cells Permissive for Latent HIV-1 Infection

效应细胞向记忆细胞转变过程中的转录重编程使CD4+ T细胞易于感染潜伏性HIV-1病毒

Liang Shan ,Kai Deng ,Hongbo Gao ,Sifei Xing ,Adam A Capoferri ,Christine M Durand ,S Alireza Rabi ,Gregory M Laird ,Michelle Kim ,Nina N Hosmane ,Hung-Chih Yang ,Hao Zhang ,Joseph B Margolick ,Linghua Li ,Weiping Cai ,Ruian Ke ,Richard A Flavell ,Janet D Siliciano ,Robert F Siliciano