日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting the ribosome to treat multiple myeloma

针对核糖体治疗多发性骨髓瘤

Kylee H Maclachlan, Kezia Gitareja, Jian Kang, Andrew Cuddihy, Yuxi Cao, Nadine Hein, Carleen Cullinane, Ching-Seng Ang, Natalie Brajanovski, Richard B Pearson, Amit Khot, Elaine Sanij, Ross D Hannan, Gretchen Poortinga, Simon J Harrison

CX-5461 Preferentially Induces Top2α-Dependent DNA Breaks at Ribosomal DNA Loci

CX-5461 优先诱导核糖体 DNA 位点的 Top2α 依赖性 DNA 断裂

Donald P Cameron, Jirawas Sornkom, Sameerh Alsahafi, Denis Drygin, Gretchen Poortinga, Grant A McArthur, Nadine Hein, Ross Hannan, Konstantin I Panov

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

CX-5461 激活 DNA 损伤反应并证明对高级别浆液性卵巢癌具有治疗作用

Elaine Sanij #, Katherine M Hannan #, Jiachen Xuan, Shunfei Yan, Jessica E Ahern, Anna S Trigos, Natalie Brajanovski, Jinbae Son, Keefe T Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J Wakefield, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Andrew J

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

重新编程的mRNA翻译驱动对核糖体生物合成治疗靶向性的抵抗

Eric P Kusnadi, Anna S Trigos, Carleen Cullinane, David L Goode, Ola Larsson, Jennifer R Devlin, Keefe T Chan, David P De Souza, Malcolm J McConville, Grant A McArthur, George Thomas, Elaine Sanij, Gretchen Poortinga, Ross D Hannan, Katherine M Hannan #, Jian Kang #, Richard B Pearson #

Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation

长距离 rDNA-基因组相互作用的变化与恶性转化过程中 RNA 聚合酶 II 基因程序的改变有关

Jeannine Diesch, Megan J Bywater, Elaine Sanij, Donald P Cameron, William Schierding, Natalie Brajanovski, Jinbae Son, Jirawas Sornkom, Nadine Hein, Maurits Evers, Richard B Pearson, Grant A McArthur, Austen R D Ganley, Justin M O'Sullivan, Ross D Hannan, Gretchen Poortinga

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

抑制 Pol I 转录可通过靶向白血病起始细胞群来治疗小鼠和人类 AML

Nadine Hein, Donald P Cameron, Katherine M Hannan, Nhu-Y N Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch, Jennifer R Devlin, Amee J George, Elaine Sanij, Jaclyn Quin, Gretchen Poortinga, Inge Verbrugge, Adele Baker, Denis Drygin, Simon J Harriso

Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene

Eμ-Myc 小鼠淋巴瘤的基因组表征表明 Bcor 是一种 Myc 协同肿瘤抑制基因

Marcus Lefebure, Richard W Tothill, Elizabeth Kruse, Edwin D Hawkins, Jake Shortt, Geoffrey M Matthews, Gareth P Gregory, Benjamin P Martin, Madison J Kelly, Izabela Todorovski, Maria A Doyle, Richard Lupat, Jason Li, Jan Schroeder, Meaghan Wall, Stuart Craig, Gretchen Poortinga, Don Cameron, Megan

Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth

定义 FBP/KSRP 蛋白的基本功能:果蝇 Psi 与介导复合物相互作用,调节 MYC 转录和组织生长

Linna Guo, Olga Zaysteva, Zuqin Nie, Naomi C Mitchell, Jue Er Amanda Lee, Thomas Ware, Linda Parsons, Rodney Luwor, Gretchen Poortinga, Ross D Hannan, David L Levens, Leonie M Quinn

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

CX-5461 抑制 RNA 聚合酶 I 转录起始可激活非典型 ATM/ATR 信号

Jaclyn Quin, Keefe T Chan, Jennifer R Devlin, Donald P Cameron, Jeannine Diesch, Carleen Cullinane, Jessica Ahern, Amit Khot, Nadine Hein, Amee J George, Katherine M Hannan, Gretchen Poortinga, Karen E Sheppard, Kum Kum Khanna, Ricky W Johnstone, Denis Drygin, Grant A McArthur, Richard B Pearson, El

Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models

dMYC 的 Hfp 依赖性转录抑制缺陷是果蝇 XPB 模型中组织过度生长的基础

Jue Er Amanda Lee, Naomi C Mitchell, Olga Zaytseva, Arjun Chahal, Peter Mendis, Amandine Cartier-Michaud, Linda M Parsons, Gretchen Poortinga, David L Levens, Ross D Hannan, Leonie M Quinn