日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dorsal root ganglion toxicity after AAV intra-CSF delivery of a RNAi expression construct into non-human primates and mice.

将 RNAi 表达构建体通过 AAV 脑脊液内递送至非人灵长类动物和小鼠后,引起背根神经节毒性

Hawley Zachary C E, Pardo Ingrid D, Cao Shaolong, Zavodszky Maria I, Casey Fergal, Ferber Kyle, Luo Yi, Hana Sam, Chen Shukkwan K, Doherty Jessica, Costa Raquel, Cullen Patrick, Liu Yuqing, Carlile Thomas M, Chowdhury Twinkle, Doyle Benjamin, Clarner Pete, Mangaudis Kevin, Guilmette Edward, Bourque Shawn, Koske David, Nadella Murali V P, Trapa Patrick, Hawes Michael L, Raitcheva Denitza, Lo Shih-Ching

Viral-mediated knockdown of Atxn2 attenuates TDP-43 pathology and muscle dysfunction in the PFN1(C71G) ALS mouse model.

病毒介导的 Atxn2 敲低可减轻 PFN1(C71G) ALS 小鼠模型中的 TDP-43 病理和肌肉功能障碍

Hawley Zachary C E, Li Xueying, Bodnar Dora, Gu Yuanzheng, Luo Yi, Ferretti Daniel, Sheehy Adam, Driscoll Rachelle, Zavodszky Maria I, Cao Shaolong, Isaza Isabel, Jandreski Luke, Liu Yuqing, Carlile Thomas, Lo Shih-Ching, Grimard Anna, Bourque Shawn, Utturkar Aditya, Desmarais Samantha, Arnold H Moore, Huh Dann, Guilmette Edward, Kwon Deborah Y

Detecting MUNC18-1 related presynaptic dysfunction and rescue in human iPSC-derived neurons

检测MUNC18-1相关的突触前功能障碍及在人iPSC衍生神经元中的修复

Long, Manzhao; Gallo, Nicholas B; Zoll, Jennifer; Unnikrishnan, Sharanya; Guilmette, Edward; Gianni, Davide; Wu, Sijia; Hinckley, Christopher A

Engineered microRNA scaffolds for potent gene silencing in vivo.

工程化microRNA支架用于体内强效基因沉默

Militello Giuseppe, Greig Alyssa, Bi Chongfeng, Vasileva Ana, Zavodszky Maria I, Lo Shih-Ching, Guilmette Edward, Clarner Pete, Liu Bin, Bhat Guruharsha, Suh Junghae, Dow Lukas, Zuber Johannes, Fellmann Christof, Premsrirut Prem K

The Parkinson's disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release

帕金森病相关基因ITPKB通过调节内质网到线粒体的钙释放来防止α-突触核蛋白聚集。

Apicco, Daniel J; Shlevkov, Evgeny; Nezich, Catherine L; Tran, David T; Guilmette, Edward; Nicholatos, Justin W; Bantle, Collin M; Chen, Yi; Glajch, Kelly E; Abraham, Neeta A; Dang, Lan T; Kaynor, G Campbell; Tsai, Ellen A; Nguyen, Khanh-Dung H; Groot, Joost; Liu, YuTing; Weihofen, Andreas; Hurt, Jessica A; Runz, Heiko; Hirst, Warren D

Transcriptomic analysis of genetically defined autism candidate genes reveals common mechanisms of action

对已确定的自闭症候选基因进行转录组分析,揭示了共同的作用机制

Lanz, Thomas A; Guilmette, Edward; Gosink, Mark M; Fischer, James E; Fitzgerald, Lawrence W; Stephenson, Diane T; Pletcher, Mathew T