日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Structure of the human P2X3 receptor reveals the basis for subtype-selective inhibition by sivopixant

人P2X3受体的结构揭示了西沃匹沙特亚型选择性抑制的基础

期刊:PLoS Biology
影响因子:7.2
doi:10.1371/journal.pbio.3003777
Zhao, Zhixuan; Wang, Dong-Ping; Zhang, Xin; Gao, Yuan; Xu, Hexin; Teng, Xinyu; Shen, Cheng; Chen, Jirui; Zhang, Jinru; Guo, Chang-Run; Hattori, Motoyuki
信号转导
发表日期：2026
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Understanding interspecies drug response variations between human and rodent P2X7 receptors

了解人类和啮齿动物P2X7受体之间的种间药物反应差异

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-65847-0
Guo, Chang-Run; Sheng, Danqi; Li, Ji-Yuan; Li, Tian-Tian; Yao, Jia-Bao; Zhang, Rui; Huang, Ye; Zhao, Ying-Ying; Wang, Dong-Ping; Chen, Jie; Li, Jian; Wang, Jiang; Zhou, Yu; Shen, Cheng; Jin, Fei; Cao, Peng; Hattori, Motoyuki; Liu, Hong; Yu, Ye
信号转导
发表日期：2025
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A shared mechanism for TNP-ATP recognition by members of the P2X receptor family

P2X受体家族成员识别TNP-ATP的共同机制

期刊:Computational and Structural Biotechnology Journal
影响因子:4.1
doi:10.1016/j.csbj.2023.12.005
Ma, Xiao-Bo; Yue, Chen-Xi; Liu, Yan; Yang, Yang; Wang, Jin; Yang, Xiao-Na; Huang, Li-Dong; Zhu, Michael X; Hattori, Motoyuki; Li, Chang-Zhu; Yu, Ye; Guo, Chang-Run
信号转导
发表日期：2024
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Chronic cough relief by allosteric modulation of P2X3 without taste disturbance.

通过变构调节 P2X3 缓解慢性咳嗽，且不影响味觉

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-023-41495-0
Guo Chang-Run, Zhang Zhong-Zhe, Zhou Xing, Sun Meng-Yang, Li Tian-Tian, Lei Yun-Tao, Gao Yu-Hao, Li Qing-Quan, Yue Chen-Xi, Gao Yu, Lin Yi-Yu, Hao Cui-Yun, Li Chang-Zhu, Cao Peng, Zhu Michael X, Rong Ming-Qiang, Wang Wen-Hui, Yu Ye
发表日期：2023
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P2X3-selective mechanism of Gefapixant, a drug candidate for the treatment of refractory chronic cough

吉法匹坦（Gefapixant）是一种治疗难治性慢性咳嗽的候选药物，其作用机制为P2X3选择性作用。

期刊:Computational and Structural Biotechnology Journal
影响因子:4.1
doi:10.1016/j.csbj.2022.03.030
Cui, Wen-Wen; Wang, Si-Yu; Zhang, Yu-Qing; Wang, Yao; Fan, Ying-Zhe; Guo, Chang-Run; Li, Xing-Hua; Lei, Yun-Tao; Wang, Wen-Hui; Yang, Xiao-Na; Hattori, Motoyuki; Li, Chang-Zhu; Wang, Jin; Yu, Ye
发表日期：2022
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Dynamic recognition of naloxone, morphine and endomorphin1 in the same pocket of µ-opioid receptors.

γ-阿片受体的同一口袋中动态识别纳洛酮、吗啡和内啡肽1

期刊:Frontiers in Molecular Biosciences
影响因子:4
doi:10.3389/fmolb.2022.925404
Zhang Xin, Sun Meng-Yang, Zhang Xue, Guo Chang-Run, Lei Yun-Tao, Wang Wen-Hui, Fan Ying-Zhe, Cao Peng, Li Chang-Zhu, Wang Rui, Li Xing-Hua, Yu Ye, Yang Xiao-Na
信号转导
发表日期：2022
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Timosaponin B-II ameliorates diabetic nephropathy via TXNIP, mTOR, and NF-κB signaling pathways in alloxan-induced mice

在阿洛沙诱导的糖尿病小鼠模型中，Timosaponin B-II 通过 TXNIP、mTOR 和 NF-κB 信号通路改善糖尿病肾病。

期刊:Drug Design Development and Therapy
影响因子:5.1
doi:10.2147/DDDT.S96435
Yuan, Yong-Liang; Guo, Chang-Run; Cui, Ling-Ling; Ruan, Shi-Xia; Zhang, Chun-Feng; Ji, De; Yang, Zhong-Lin; Li, Fei
mTOR
信号转导
NF-κB
TXNIP
代谢
糖尿病
糖尿病肾病
发表日期：2015
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