日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PI3Kα Inhibitor and Degrader Inavolisib Can Co-opt FGFR2 to Enhance Responses in Patients with PIK3CA-Mutated Solid Tumors and in Preclinical Models.

PI3Kα抑制剂和降解剂Inavolisib可利用FGFR2增强PIK3CA突变实体瘤患者和临床前模型的疗效。

Juric Dejan, Song Kyung, Johnson Radia M, Accordino Melissa K, Bedard Philippe L, Cervantes Andrés, Gambardella Valentina, Hamilton Erika, Italiano Antoine, Kalinsky Kevin, Krop Ian E, Oliveira Mafalda, Saura Cristina, Schmid Peter, Turner Nicholas C, Varga Andreea, Gendreau Steven, Hwang Michael S, Kuang Zheng, Lau Jeffrey T, Lin Eva, Pham Trang, Maddalo Danilo, Rees Matthew G, Ronan Melissa M, Roth Jennifer A, Martin Scott, Sodir Nicole M, Sokol Ethan S, Whitfield Zachary J, Wong Alice, Yauch Robert L, Aimi Junko, Cheeti Sravanthi, Fredrickson Jill, Hilz Stephanie, Hafner Marc, Hutchinson Katherine E, Jin Yanling, Peters Ubong, Zingg Daniel, Royer-Joo Stephanie, Shankar Noopur, Schutzman Jennifer L, Jhaveri Komal L, Dey Anwesha

Epiregulon: Single-cell transcription factor activity inference to predict drug response and drivers of cell states.

Epiregulon:通过单细胞转录因子活性推断来预测药物反应和细胞状态的驱动因素

Włodarczyk Tomasz, Lun Aaron, Wu Diana, Shi Minyi, Ye Xiaofen, Menon Shreya, Toneyan Shushan, Seidel Kerstin, Wang Liang, Tan Jenille, Chen Shang-Yang, Keyes Timothy, Chlebowski Aleksander, Waddell Adrian, Zhou Wei, Wang Yangmeng, Yuan Qiuyue, Guo Yu, Chen Liang-Fu, Daniel Bence, Hafner Antonina, He Meng, Chibly Alejandro, Liang Yuxin, Duren Zhana, Metcalfe Ciara, Hafner Marc, Siebel Christian W, Corces M Ryan, Yauch Robert, Xie Shiqi, Yao Xiaosai

Corrigendum to "Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data"

关于“综合蛋白质组学元数据和集成网络门户促进LINCS多组学数据的共享和整合”一文的更正

Vidović, Dušica; Shamsaei, Behrouz; Schürer, Stephan C; Kogan, Phillip; Chojnacki, Szymon; Kouril, Michal; Medvedovic, Mario; Niu, Wen; Azeloglu, Evren U; Birtwistle, Marc R; Chen, Yibang; Chen, Tong; Hansen, Jens; Hu, Bin; Iyengar, Ravi; Jayaraman, Gomathi; Li, Hong; Liu, Tong; Sobie, Eric A; Xiong, Yuguang; Berberich, Matthew J; Bradshaw, Gary; Chung, Mirra; Everley, Robert A; Gaudio, Ben; Hafner, Marc; Kalocsay, Marian; Mills, Caitlin E; Nariya, Maulik K; Sorger, Peter K; Subramanian, Kartik; Victor, Chiara; Banuelos, Maria; Dardov, Victoria; Holewinski, Ronald; Manalo, Danica-Mae; Mandefro, Berhan; Matlock, Andrea D; Ornelas, Loren; Sareen, Dhruv; Svendsen, Clive N; Vaibhav, Vineet; Van Eyk, Jennifer E; Venkatraman, Vidya; Finkbiener, Steve; Fraenkel, Ernest; Rothstein, Jeffrey; Thompson, Leslie; Asiedu, Jacob; Carr, Steven A; Christianson, Karen E; Davison, Desiree; Dele-Oni, Deborah O; DeRuff, Katherine C; Egri, Shawn B; Vaca Jacome, Alvaro Sebastian; Jaffe, Jacob D; Lam, Daniel; Litichevskiy, Lev; Lu, Xiaodong; Mullahoo, James; Officer, Adam; Papanastasiou, Malvina; Peckner, Ryan; Toder, Caidin; Blanchard, Joel; Bula, Michael; Ko, Tak; Tsai, Li-Huei; Young, Jennie Z; Sharma, Vagisha; Meller, Jarek; MacCoss, Michael J

Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data

全面的蛋白质组学元数据和集成式网络门户促进了LINCS多组学数据的共享和整合。

Vidović, Dušica; Shamsaei, Behrouz; Schürer, Stephan C; Kogan, Phillip; Chojnacki, Szymon; Kouril, Michal; Medvedovic, Mario; Niu, Wen; Azeloglu, Evren U; Birtwistle, Marc R; Chen, Yibang; Chen, Tong; Hansen, Jens; Hu, Bin; Iyengar, Ravi; Jayaraman, Gomathi; Li, Hong; Liu, Tong; Sobie, Eric A; Xiong, Yuguang; Berberich, Matthew J; Bradshaw, Gary; Chung, Mirra; Everley, Robert A; Gaudio, Ben; Hafner, Marc; Kalocsay, Marian; Mills, Caitlin E; Nariya, Maulik K; Sorger, Peter K; Subramanian, Kartik; Victor, Chiara; Banuelos, Maria; Dardov, Victoria; Holewinski, Ronald; Manalo, Danica-Mae; Mandefro, Berhan; Matlock, Andrea D; Ornelas, Loren; Sareen, Dhruv; Svendsen, Clive N; Vaibhav, Vineet; Van Eyk, Jennifer E; Venkatraman, Vidya; Finkbiener, Steve; Fraenkel, Ernest; Rothstein, Jeffrey; Thompson, Leslie; Asiedu, Jacob; Carr, Steven A; Christianson, Karen E; Davison, Desiree; Dele-Oni, Deborah O; DeRuff, Katherine C; Egri, Shawn B; Jacome, Alvaro Sebastian Vaca; Jaffe, Jacob D; Lam, Daniel; Litichevskiy, Lev; Lu, Xiaodong; Mullahoo, James; Officer, Adam; Papanastasiou, Malvina; Peckner, Ryan; Toder, Caidin; Blanchard, Joel; Bula, Michael; Ko, Tak; Tsai, Li-Huei; Young, Jennie Z; Sharma, Vagisha; Pillai, Ajay; Meller, Jarek; MacCoss, Michael J

KRAS Codon-Specific Mutations Differentially Toggle PI3K Pathway Signaling and Alter Sensitivity to Inavolisib (GDC-0077).

KRAS 密码子特异性突变差异性地切换 PI3K 通路信号传导并改变对 Inavolisib (GDC-0077) 的敏感性。

Song Kyung W, Ong Christy C, Lin Eva, Lau Jeff, Sodir Nicole M, Jin Dexter X, Hutchinson Katherine E, Xie Shiqi, Tan Jenille, Liang Yuxin, Modrusan Zora, Martin Scott E, Maddalo Danilo, Hafner Marc, Dey Anwesha

Transformer-based modeling of Clonal Selection and Expression Dynamics reveals resistance mechanisms in breast cancer.

基于Transformer的克隆选择和表达动力学建模揭示了乳腺癌的耐药机制

Maulding Nathan D, Zou Jun, Zhou Wei, Metcalfe Ciara, Stuart Joshua M, Ye Xin, Hafner Marc

CDK4/6i-treated HR+/HER2- breast cancer tumors show higher ESR1 mutation prevalence and more altered genomic landscape

接受 CDK4/6 抑制剂治疗的 HR+/HER2- 乳腺癌肿瘤表现出更高的 ESR1 突变率和更显著的基因组改变。

Chaudhary, Nayan; Chibly, Alejandro M; Collier, Ann; Martinalbo, Jorge; Perez-Moreno, Pablo; Moore, Heather M; Luhn, Patricia; Metcalfe, Ciara; Hafner, Marc

heredERA Breast Cancer: a phase III, randomized, open-label study evaluating the efficacy and safety of giredestrant plus the fixed-dose combination of pertuzumab and trastuzumab for subcutaneous injection in patients with previously untreated HER2-positive, estrogen receptor-positive locally advanced or metastatic breast cancer

heredERA乳腺癌:一项III期、随机、开放标签研究,旨在评估giredestrant联合固定剂量帕妥珠单抗和曲妥珠单抗皮下注射治疗既往未接受治疗的HER2阳性、雌激素受体阳性局部晚期或转移性乳腺癌患者的疗效和安全性。

Kuemmel, Sherko; Harper-Wynne, Catherine; Park, Yeon Hee; Franke, Fábio; de Laurentiis, Michelino; Schumacher-Wulf, Eva; Eiger, Daniel; Heeson, Sarah; Cardona, Andrés; Özyilkan, Özgür; Morales-Vàsquez, Flavia; Metcalfe, Ciara; Hafner, Marc; Restuccia, Eleonora; O'Shaughnessy, Joyce

UGT1A4 Polymorphism is not Associated with a Clinically Relevant Change in Giredestrant Exposure

UGT1A4 多态性与吉瑞地司他暴露量的临床相关变化无关

Malhi, Vikram; Nowicka, Malgorzata; Chen, Ya-Chi; Agarwal, Priya; Waldvogel, Marie; Lien, Yi Ting Kayla; Hafner, Marc; Perez-Moreno, Pablo; Moore, Heather M; Yu, Jiajie

PharmacoDB 2.0: improving scalability and transparency of in vitro pharmacogenomics analysis

PharmacoDB 2.0:提高体外药物基因组学分析的可扩展性和透明度

Feizi, Nikta; Nair, Sisira Kadambat; Smirnov, Petr; Beri, Gangesh; Eeles, Christopher; Esfahani, Parinaz Nasr; Nakano, Minoru; Tkachuk, Denis; Mammoliti, Anthony; Gorobets, Evgeniya; Mer, Arvind Singh; Lin, Eva; Yu, Yihong; Martin, Scott; Hafner, Marc; Haibe-Kains, Benjamin