CYB5R3 functions as a tumor suppressor by inducing ER stress-mediated apoptosis in lung cancer cells via the PERK-ATF4 and IRE1α-JNK pathways
CYB5R3通过PERK-ATF4和IRE1α-JNK通路诱导肺癌细胞发生内质网应激介导的细胞凋亡，从而发挥抑癌作用。
期刊:Experimental and Molecular Medicine
影响因子:9.5
doi:10.1038/s12276-024-01155-9
Joo-Young Im,Soo Jin Kim,Jong-Lyul Park,Tae-Hee Han,Woo-Il Kim,Inhyub Kim,Bomin Ko,So-Young Chun,Mi-Jung Kang,Bo-Kyung Kim,Sol A Jeon,Seon-Kyu Kim,Incheol Ryu,Seon-Young Kim,Ki-Hoan Nam,Inah Hwang,Hyun Seung Ban,Misun Won
肺癌
细胞生物学
信号转导
肿瘤
表观遗传
JNK
PERK
ATF4
Apoptosis
凋亡
