日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A community-led initiative to de-risk and advance Parkinson's disease therapeutic targets

一项由社区主导的倡议,旨在降低帕金森病治疗靶点的风险并推进其发展

Vaiana, Alexandra; Behr, Jonathan; Birol, Ryan; Blauwendraat, Cornelis; Casey, Bradford; Chowdhury, Kushan; Citron, Martin; Crapser, Joshua; Dardov, Victoria; Ducotterd, Fiona; Dumanis, Sonya; Dunlop, John; Durborow, Michelle; Fiske, Brian; Golden, Jessica; Hannestad, Jonas; Hung, Wendy; Kemp, Jennifer; Kleiman, Robin; Knight, Adam; Koemeter-Cox, Andrew; Leuchter, Bruce; Logsdon, Bejamin A; Marreiros, Rita; Miller, Julie E; Mitchell, Amanda; Mukherjee, Pooja; Navarro, Grace; Nelson, Matthew R; Nikolich, Karoly; Otis, Tom; Polinski, Nicole; Rastegar-Pouyani, Shima; Reith, Alastair D; Riley, Ekemini; Rubin, Lee; Ryten, Mina; Sadick, Jessica; Schwabe, Tina; Sherer, Todd; Silvergleid, Sarah; Singleton, Andrew; St Clair, Lara; Stoehr, Jan; Stone, David J; Sullivan, Julianna; Tanenbaum, Nicole; Tinelli, Elisa; Trimble, Kate; Wang, Yifei; Weninger, Stacie; Wiggenhauser, Nicolás; Wood, Stephen; Schoepp, Darryle; Buggia-Prevot, Virginie; Padmanabhan, Shalini; Skibinski, Gaia

A randomized, placebo-controlled first-in-human study of oral TQS-168 in healthy volunteers: Assessment of safety, tolerability, pharmacokinetics, pharmacodynamics, and food effect

一项在健康志愿者中进行的随机、安慰剂对照的首次人体口服TQS-168研究:评估其安全性、耐受性、药代动力学、药效学和食物效应。

Hannestad, Jonas; Smith, Steven; Lam, Andrew; Hurt, Janet; Harada, Nicole; Kim, Richard; Das, Abhirup; Brunello, Juliana; Whitaker, Gareth; Chalmers, David; Senjoti, Faria; Lin, Wu; Coghill, James; Bansal, Yogesh; Sidhu, Sharan; Zann, Vanessa; Liu, Enchi

Drug characteristics derived from kinetic modeling: combined (11)C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A

基于动力学模型的药物特性:结合(11)C-UCB-J人体PET成像和左乙拉西坦及布瓦西坦在SV2A上的占有率

Naganawa, Mika; Gallezot, Jean-Dominique; Finnema, Sjoerd J; Maguire, Ralph Paul; Mercier, Joël; Nabulsi, Nabeel B; Kervyn, Sophie; Henry, Shannan; Nicolas, Jean-Marie; Huang, Yiyun; Chen, Ming-Kai; Hannestad, Jonas; Klitgaard, Henrik; Stockis, Armel; Carson, Richard E

Single-vesicle imaging reveals lipid-selective and stepwise membrane disruption by monomeric α-synuclein

单囊泡成像揭示了单体α-突触核蛋白对脂质的选择性和逐步膜破坏作用

Hannestad, Jonas K; Rocha, Sandra; Agnarsson, Björn; Zhdanov, Vladimir P; Wittung-Stafshede, Pernilla; Höök, Fredrik

Safety and tolerability of GRF6019 in mild-to-moderate Alzheimer's disease dementia

GRF6019在轻度至中度阿尔茨海默病痴呆症中的安全性和耐受性

Hannestad, Jonas; Koborsi, Katie; Klutzaritz, Vicki; Chao, Whitney; Ray, Rebecca; Páez, Antonio; Jackson, Sam; Lohr, Scott; Cummings, Jeffrey L; Kay, Gary; Nikolich, Karoly; Braithwaite, Steven

Padsevonil randomized Phase IIa trial in treatment-resistant focal epilepsy: a translational approach

Padsevonil治疗难治性局灶性癫痫的随机IIa期试验:转化研究

Muglia, Pierandrea; Hannestad, Jonas; Brandt, Christian; DeBruyn, Steven; Germani, Massimiliano; Lacroix, Brigitte; Majoie, Marian; Otoul, Christian; Sciberras, David; Steinhoff, Bernhard J; Van Laere, Koen; Van Paesschen, Wim; Webster, Elizabeth; Kaminski, Rafal M; Werhahn, Konrad J; Toledo, Manuel

Inverse changes in raphe and cortical 5-HT(1B) receptor availability after acute tryptophan depletion in healthy human subjects

健康人体急性色氨酸耗竭后,中缝核和皮质5-HT(1B)受体可用性发生反向变化

Baldassarri, Stephen R; Park, Eunkyung; Finnema, Sjoerd J; Planeta, Beata; Nabulsi, Nabeel; Najafzadeh, Soheila; Ropchan, Jim; Huang, Yiyun; Hannestad, Jonas; Maloney, Kathleen; Bhagwagar, Zubin; Carson, Richard E

Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study

代谢型谷氨酸受体5和谷氨酸在重度抑郁症中的作用:一项多模态影像学研究

Abdallah, Chadi G; Hannestad, Jonas; Mason, Graeme F; Holmes, Sophie E; DellaGioia, Nicole; Sanacora, Gerard; Jiang, Lihong; Matuskey, David; Satodiya, Ritvij; Gasparini, Fabrizio; Lin, Xin; Javitch, Jonathan; Planeta, Beata; Nabulsi, Nabeel; Carson, Richard E; Esterlis, Irina

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

利用PET成像技术对人体内脂多糖给药后的小胶质细胞活化进行成像。

Sandiego, Christine M; Gallezot, Jean-Dominique; Pittman, Brian; Nabulsi, Nabeel; Lim, Keunpoong; Lin, Shu-Fei; Matuskey, David; Lee, Jae-Yun; O'Connor, Kevin C; Huang, Yiyun; Carson, Richard E; Hannestad, Jonas; Cosgrove, Kelly P

Dopamine D₃ receptor alterations in cocaine-dependent humans imaged with [¹¹C](+)PHNO

利用[¹¹C](+)PHNO成像可卡因依赖者体内多巴胺D₃受体的改变

Matuskey, David; Gallezot, Jean-Dominique; Pittman, Brian; Williams, Wendol; Wanyiri, Jane; Gaiser, Edward; Lee, Dianne E; Hannestad, Jonas; Lim, Keunpoong; Zheng, Minq-Qiang; Lin, Shu-fei; Labaree, David; Potenza, Marc N; Carson, Richard E; Malison, Robert T; Ding, Yu-Shin