日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies

反向激动性纳米抗体揭示非典型趋化因子受体的组成型活性

Perez Almeria, Claudia V; Otun, Omolade; Schlimgen, Roman; Lamme, Thomas D; Di Niro, Lotte; Crudden, Caitrin; Bebelman, Jan Paul; Youssef, Noureldine; Musli, Lejla; Jenjak, Shawn; Bobkov, Vladimir; Drube, Julia; Hoffmann, Carsten; Volkman, Brian F; Granier, Sébastien; Bechara, Cherine; Siderius, Marco; Heukers, Raimond; Schafer, Christopher T; Smit, Martine J

Disruption of constitutive CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms.

CXCR4 寡聚体的组成破坏会损害淋巴瘤的致癌特性

Mobach Simon, Bergkamp Nick D, Ma Ziliang, Haselager Marco V, Anbuhl Stephanie M, Jurriens Daphne, van den Bor Jelle, Wang Ziming, Crudden Caitrin, Roos Jamie L, Perez Almeria Claudia V, Boergonje Rick A, Lohse Martin J, Bosma Reggie, Eldering Eric, Siderius Marco, Wu Wei, Spaargaren Marcel, Tonino Sanne H, Kater Arnon P, Smit Martine J, Heukers Raimond

TR-FRET between engineered nanobodies reveals the existence of endogenous CXCR4 oligomers

利用工程纳米抗体之间的时间分辨荧光共振能量转移(TR-FRET)技术揭示了内源性CXCR4寡聚体的存在。

Heuninck, Joyce; Bobkov, Vladimir; Grison, Claire M; Fumagalli, Amos; Lescuyer, Mathias; Otun, Omolade; Bechara, Cherine; Lamarque, Laurent; Trinquet, Eric; Bachelerie, Françoise; Marin, Philippe; Mouillac, Bernard; Granier, Sébastien; van der Woning, Bas; de Haard, Hans; Smit, Martine J; Heukers, Raimond; Durroux, Thierry

Genetic Engineering of VHH Antibody Fragments for Efficient Site-Specific Conjugation to Polysaccharides.

利用基因工程技术对VHH抗体片段进行高效位点特异性偶联,以与多糖结合

Zhong Lin, Morshuis Lisanne C M, Koerselman Michelle, Memelink Angela, Kolecka Anna, Heukers Raimond, Verrips Theo, Karperien Marcel, Zoetebier Bram

Plasma membrane rather than endosomal Gq signaling drives transcriptional activity by the viral chemokine receptor US28 in glioblastoma

在胶质母细胞瘤中,病毒趋化因子受体US28的转录活性是由质膜而非内体Gq信号传导驱动的。

Daly, Carole; Wright, Adam; Heukers, Raimond; McKee, Chloe M; Coll, Rebecca C; Evergren, Emma; Smit, Martine J; Thomsen, Alex R B; Plouffe, Bianca

Molecular characterization of the CXCR4 / CXCR7 axis in germ cell tumors and its targetability using nanobody-drug-conjugates

生殖细胞肿瘤中CXCR4/CXCR7轴的分子特征及其纳米抗体-药物偶联靶向性研究

Wakileh, Gamal A; Bierholz, Philipp; Kotthoff, Mara; Skowron, Margaretha A; Bremmer, Felix; Stephan, Alexa; Anbuhl, Stephanie M; Heukers, Raimond; Smit, Martine J; Ströbel, Philipp; Nettersheim, Daniel

Anti-HIV-1 Nanobody-IgG1 Constructs With Improved Neutralization Potency and the Ability to Mediate Fc Effector Functions

具有增强的中和效力和介导Fc效应功能能力的抗HIV-1纳米抗体-IgG1构建体

Schriek, Angela I; van Haaren, Marlies M; Poniman, Meliawati; Dekkers, Gillian; Bentlage, Arthur E H; Grobben, Marloes; Vidarsson, Gestur; Sanders, Rogier W; Verrips, Theo; Geijtenbeek, Teunis B H; Heukers, Raimond; Kootstra, Neeltje A; de Taeye, Steven W; van Gils, Marit J

P1530: PERITRANFUSIONAL C1-INHIBITOR IN PATIENTS WITH SEVERE COMPLEMENT-MEDIATED AUTOIMMUNE HEMOLYTIC ANEMIA: AN OPEN LABEL PHASE 2 TRIAL

P1530:输血期C1抑制剂治疗重症补体介导的自身免疫性溶血性贫血患者:一项开放标签的II期试验

Schriek, Angela I; van Haaren, Marlies M; Poniman, Meliawati; Dekkers, Gillian; Bentlage, Arthur E H; Grobben, Marloes; Vidarsson, Gestur; Sanders, Rogier W; Verrips, Theo; Geijtenbeek, Teunis B H; Heukers, Raimond; Kootstra, Neeltje A; de Taeye, Steven W; van Gils, Marit J; de Boer, E C W; Jalink, M; Delvasto-Nuñes, L; Meulenbroek, E M; Baas, I; Janssen, S R; Dijkman, E E; Gelderman, K A; Wouters, D; Engel, M D; de Haas, M; Kersten, M-J; Jongerius, I; Zeerleder, S; Vos, J M

Natural Killer Cell Hypo-responsiveness in Chronic Lymphocytic Leukemia can be Circumvented In Vitro by Adequate Activating Signaling

体外实验可通过充分的激活信号来克服慢性淋巴细胞白血病中自然杀伤细胞的低反应性。

Hofland, Tom; Endstra, Sanne; Gomes, Calum K P; de Boer, Renate; de Weerdt, Iris; Bobkov, Vladimir; Riedl, Jurgen A; Heukers, Raimond; Smit, Martine J; Eldering, Eric; Levin, Mark-David; Kater, Arnon P; Tonino, Sanne H

EGFR targeted nanobody-photosensitizer conjugates for photodynamic therapy in a pre-clinical model of head and neck cancer

EGFR靶向纳米抗体-光敏剂偶联物在头颈癌临床前模型中的光动力疗法应用

van Driel, Pieter B A A; Boonstra, Martin C; Slooter, Maxime D; Heukers, Raimond; Stammes, Marieke A; Snoeks, Thomas J A; de Bruijn, Henriette S; van Diest, Paul J; Vahrmeijer, Alexander L; van Bergen En Henegouwen, Paul M P; van de Velde, Cornelis J H; Löwik, Clemens W G M; Robinson, Dominic J; Oliveira, Sabrina