日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanistic Elucidation and Stereochemical Consequences of Alternative Binding of Alkenyl Substrates by Engineered Arylmalonate Decarboxylase

工程化芳基丙二酸脱羧酶对烯基底物选择性结合的机理阐明及立体化学后果

van der Pol, Elske; Schlatzer, Thomas; Hoffka, Gyula; Di Geronimo, Bruno; Eder, Johannes; Schweiger, Anna K; Karava, Marianna; Gross, Dominik; Fischer, Roland C; Kracher, Daniel; Kazlauskas, Romas; Miyamoto, Kenji; Kamerlin, Shina Caroline Lynn; Breinbauer, Rolf; Kourist, Robert

Enzyme Enhancement Through Computational Stability Design Targeting NMR-Determined Catalytic Hotspots

通过计算稳定性设计增强酶活性,靶向核磁共振确定的催化热点

Luis I Gutierrez-Rus ,Eva Vos ,David Pantoja-Uceda ,Gyula Hoffka ,Jose Gutierrez-Cardenas ,Mariano Ortega-Muñoz ,Valeria A Risso ,Maria Angeles Jimenez ,Shina C L Kamerlin ,Jose M Sanchez-Ruiz

Phosphorylation of ITIM motifs drives the structural transition of indoleamine 2,3-dioxygenase 1 between enzymatic and non-enzymatic states

ITIM基序的磷酸化驱动吲哚胺2,3-双加氧酶1在酶活性和非酶活性状态之间的结构转变

Hoffka, Gyula; Hornyák, Lilla; Székvölgyi, Lóránt; Miskei, Márton

Receptor Binding for the Entry Mechanisms of SARS-CoV-2: Insights from the Original Strain and Emerging Variants

SARS-CoV-2病毒进入机制的受体结合:来自原始毒株和新出现的变异株的启示

Mahdi, Mohamed; Kiarie, Irene Wanjiru; Mótyán, János András; Hoffka, Gyula; Al-Muffti, Aya Shamal; Tóth, Attila; Tőzsér, József

Modeling protease-sensitive human pancreatic lipase mutations in the mouse ortholog

在小鼠直系同源物中模拟蛋白酶敏感的人类胰腺脂肪酶突变

Gyula Hoffka, Samara Mhana, Marcell Vas, Vanda Toldi, János András Mótyán, József Tőzsér, András Szabó

Efficacy of Integrase Strand Transfer Inhibitors and the Capsid Inhibitor Lenacapavir against HIV-2, and Exploring the Effect of Raltegravir on the Activity of SARS-CoV-2

整合酶链转移抑制剂和衣壳抑制剂雷那卡帕韦对 HIV-2 的疗效以及雷替拉韦对 SARS-CoV-2 活性的影响探讨

Irene Wanjiru Kiarie, Gyula Hoffka, Manon Laporte, Pieter Leyssen, Johan Neyts, József Tőzsér, Mohamed Mahdi

P1' specificity of the S219V/R203G mutant tobacco etch virus protease

S219V/R203G突变型烟草蚀纹病毒蛋白酶的P1'特异性

Golda, Mária; Hoffka, Gyula; Cherry, Scott; Tropea, Joseph E; Lountos, George T; Waugh, David S; Wlodawer, Alexander; Tőzsér, József; Mótyán, János András

Self-inhibited State of Venezuelan Equine Encephalitis Virus (VEEV) nsP2 Cysteine Protease: A Crystallographic and Molecular Dynamics Analysis

委内瑞拉马脑炎病毒(VEEV)nsP2半胱氨酸蛋白酶的自身抑制状态:晶体学和分子动力学分析

Hoffka, Gyula; Lountos, George T; Needle, Danielle; Wlodawer, Alexander; Waugh, David S; Tőzsér, József; Mótyán, János András

Potential Resistance of SARS-CoV-2 Main Protease (Mpro) against Protease Inhibitors: Lessons Learned from HIV-1 Protease

SARS-CoV-2 主蛋白酶 (Mpro) 对蛋白酶抑制剂的潜在耐药性:从 HIV-1 蛋白酶中汲取的经验教训

Mótyán, János András; Mahdi, Mohamed; Hoffka, Gyula; Tőzsér, József

Asymmetric dynamic coupling promotes alternative evolutionary pathways in an enzyme dimer

不对称动态耦合促进酶二聚体中替代进化路径的出现。

Ambrus, V; Hoffka, Gy; Fuxreiter, M