Lactucopicrin promotes the autophagic degradation of MAP2K4/MKK4 by mediating CCDC50 palmitoylation to alleviate osteoarthritis progression.
乳酸苦苷通过介导 CCDC50 棕榈酰化促进 MAP2K4/MKK4 的自噬降解,从而缓解骨关节炎的进展。
期刊:Autophagy
影响因子:14.3
doi:10.1080/15548627.2025.2601041
Li Wenjun, Sun Qijie, Hu Konghe, Tang Dongmei, Yang Cheng, Xie Yingchao, Peng Xiaodong, Deng Yongtao, Lu Jiansen, Qi Yong, Lin Yifen, Sun Hongtao, Tian Qinyu, Xu Changpeng, Tian Xinggui, Jiang Huaji