Rhapontigenin attenuates neurodegeneration in a parkinson's disease model by downregulating mtDNA-cGAS-STING-NF-κB-mediated neuroinflammation via PINK1/DRP1-dependent microglial mitophagy.
Rhapontigenin 通过 PINK1/DRP1 依赖的小胶质细胞线粒体自噬下调 mtDNA-cGAS-STING-NF-κB 介导的神经炎症，从而减轻帕金森病模型中的神经退行性变
期刊:Cellular and Molecular Life Sciences
影响因子:6.2
doi:10.1007/s00018-025-05873-9
Su Zhongqiang, Shu Hui, Huang Xingting, Ding Liuyan, Liang Fengchu, Xu Zongtang, Zhu Ziting, Chen Minshan, Wang Xiaobei, Li Guihua, Xia Huan, Cao Qiannan, Zhang Wenlong, Xu Pingyi, Yang Xinling
神经科学
细胞生物学
帕金森
神经炎症
IGE
炎症
线粒体
自噬
