日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor that Unleashes PD-1 Checkpoint and CAR T-cell Immunotherapies

发现BMS-986408,一种首创的双重DGKα和DGKζ抑制剂,可激活PD-1检查点和CAR T细胞免疫疗法

Michael Wichroski # ,Si-Qi Liu # ,Lauren M Zasadil ,Joseph L Benci ,Patrick C Gedeon ,Kendall J Condon ,Suhasini Joshi ,Shana Posy ,Patrick Carlson ,Alison Maier ,Jiao Shen ,Rakeeb Kureshi ,Yuka Amako ,Tai Wang ,Ryan L Powles ,Yanyun Li ,Tho Lai ,Igor Katsyv ,Hongchen Qiu ,Huilin Qi ,Jessica Wong ,Dandan Zhao ,Dana Banas ,Joelle Onorato ,Gregory Locke ,Xueer Chen ,Wen-Chi Chou ,Erica Cook ,Abigail E Witt ,Christopher M Barbieri ,Hong Zhang ,Jonathan B Olsen ,Alba Font Tello ,Eugene Drokhlyansky ,Denise C Grünenfelder ,Louis Chupak ,Tyler A Longmire ,Jon C Jones ,Travis J Hollmann ,David G Kugler ,John N Feder ,Raphael Bueno ,John Wain ,Pallavur Sivakumar ,Yu Liu ,Stephanie K Dougan ,Cloud P Paweletz ,David A Barbie ,Emma Lees

PRAME expression in melanoma is negatively regulated by TET2-mediated DNA hydroxymethylation

黑色素瘤中的 PRAME 表达受到 TET2 介导的 DNA 羟甲基化的负向调控

Rui Fang, Tuulia Vallius, Arianna Zhang, Devon Van Cura, Francisco Alicandri, Grant Fischer, Elizabeth Draper, Shuyun Xu, Roxanne Pelletier, Igor Katsyv, Peter K Sorger, George F Murphy, Christine G Lian

Dysfunction of ubiquitin protein ligase MYCBP2 leads to cell resilience in human breast cancers

泛素蛋白连接酶 MYCBP2 功能障碍导致人类乳腺癌细胞恢复力

Ryan A Neff, Almudena Bosch-Gutierrez, Yifei Sun, Igor Katsyv, Won-Min Song, Minghui Wang, Martin J Walsh, Bin Zhang

A molecular single-cell lung atlas of lethal COVID-19

致命 COVID-19 的分子单细胞肺图谱

Johannes C Melms #, Jana Biermann #, Huachao Huang #, Yiping Wang #, Ajay Nair #, Somnath Tagore #, Igor Katsyv #, André F Rendeiro #, Amit Dipak Amin #, Denis Schapiro, Chris J Frangieh, Adrienne M Luoma, Aveline Filliol, Yinshan Fang, Hiranmayi Ravichandran, Mariano G Clausi, George A Alba, Meri R

Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics

Plexin-B2 通过调节细胞生物力学促进胶质母细胞瘤浸润

Yong Huang #, Rut Tejero #, Vivian K Lee, Concetta Brusco, Theodore Hannah, Taylor B Bertucci, Chrystian Junqueira Alves, Igor Katsyv, Michael Kluge, Ramsey Foty, Bin Zhang, Caroline C Friedel, Guohao Dai, Hongyan Zou, Roland H Friedel

Gene signatures of quiescent glioblastoma cells reveal mesenchymal shift and interactions with niche microenvironment

静止胶质母细胞瘤细胞的基因特征揭示了间充质转移和与微环境的相互作用

Rut Tejero, Yong Huang, Igor Katsyv, Michael Kluge, Jung-Yi Lin, Jessica Tome-Garcia, Nicolas Daviaud, Yuanshuo Wang, Bin Zhang, Nadejda M Tsankova, Caroline C Friedel, Hongyan Zou, Roland H Friedel

Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma

染色质可及性分析揭示 TEAD1 是人类胶质母细胞瘤迁移的调节剂

Jessica Tome-Garcia, Parsa Erfani, German Nudelman, Alexander M Tsankov, Igor Katsyv, Rut Tejero, Bin Zhang, Martin Walsh, Roland H Friedel, Elena Zaslavsky, Nadejda M Tsankova

Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer's disease

少突胶质细胞的多尺度网络建模揭示了阿尔茨海默病中髓鞘失调的分子成分

Andrew T McKenzie, Sarah Moyon, Minghui Wang, Igor Katsyv, Won-Min Song, Xianxiao Zhou, Eric B Dammer, Duc M Duong, Joshua Aaker, Yongzhong Zhao, Noam Beckmann, Pei Wang, Jun Zhu, James J Lah, Nicholas T Seyfried, Allan I Levey, Pavel Katsel, Vahram Haroutunian, Eric E Schadt, Brian Popko, Patrizia

PTK6 regulates growth and survival of endocrine therapy-resistant ER+ breast cancer cells

PTK6 调节内分泌治疗耐药 ER+ 乳腺癌细胞的生长和存活

Koichi Ito #, Sun Hee Park #, Igor Katsyv, Weijia Zhang, Carmine De Angelis, Rachel Schiff, Hanna Y Irie

PRKCQ promotes oncogenic growth and anoikis resistance of a subset of triple-negative breast cancer cells

PRKCQ 促进三阴性乳腺癌细胞亚群的致癌生长和抗细胞凋亡

Jessica Byerly, Gwyneth Halstead-Nussloch, Koichi Ito, Igor Katsyv, Hanna Y Irie