日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy

微调 BACH2 剂量可平衡干细胞特性和效应功能,从而增强抗肿瘤 T 细胞疗法。

Conti, Alberto G; Evans, Alexander C; von Linde, Teresa; Deguit, Christian Deo T; Whiteside, Sarah K; Wesolowski, Alexander J; Imianowski, Charlotte J; Yamashita-Kanemaru, Yumi; Dahmani, Layla; Chapman, Jack; Pillay, Ardon M; Al-Deka, Aws; Greaves, Randy; Burton, Oliver; Vardaka, Panagiota; Sampurno, Shienny; Pérez-Núñez, Iván; Saw, Nicole Y L; Yang, Jie; Howden, Andrew J M; Okkenhaug, Klaus; Mitra, Suman; Swiatczak, Bartlomiej; Parish, Ian A; Roychoudhuri, Rahul

Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity

阿司匹林通过限制血小板TXA2对T细胞免疫的抑制作用来预防转移。

Jie Yang ,Yumi Yamashita-Kanemaru ,Benjamin I Morris ,Annalisa Contursi ,Daniel Trajkovski ,Jingru Xu ,Ilinca Patrascan ,Jayme Benson ,Alexander C Evans ,Alberto G Conti ,Aws Al-Deka ,Layla Dahmani ,Adnan Avdic-Belltheus ,Baojie Zhang ,Hanneke Okkenhaug ,Sarah K Whiteside ,Charlotte J Imianowski ,Alexander J Wesolowski ,Louise V Webb ,Simone Puccio ,Stefania Tacconelli ,Annalisa Bruno ,Sara Di Berardino ,Alessandra De Michele ,Heidi C E Welch ,I-Shing Yu ,Shu-Wha Lin ,Suman Mitra ,Enrico Lugli ,Louise van der Weyden ,Klaus Okkenhaug ,Kourosh Saeb-Parsy ,Paola Patrignani ,David J Adams ,Rahul Roychoudhuri

Gut microbiota-derived hexa-acylated lipopolysaccharides enhance cancer immunotherapy responses

肠道菌群来源的六酰化脂多糖可增强癌症免疫疗法反应

Puspendu Sardar # ,Benjamin S Beresford-Jones # ,Wangmingyu Xia # ,Omar Shabana ,Satoshi Suyama ,Ruben J F Ramos ,Amelia T Soderholm ,Panagiotis Tourlomousis ,Paula Kuo ,Alexander C Evans ,Charlotte J Imianowski ,Alberto G Conti ,Alexander J Wesolowski ,Natalie M Baker ,Emily A L McCord ,Klaus Okkenhaug ,Sarah K Whiteside ,Rahul Roychoudhuri ,Clare E Bryant ,Justin R Cross ,Virginia A Pedicord

Perturbing local steroidogenesis to improve breast cancer immunity.

干扰局部类固醇生成以提高乳腺癌免疫力

Zhao Qiuchen, Pramanik Jhuma, Lu Yongjin, Homer Natalie Z M, Imianowski Charlotte J, Zhang Baojie, Iqbal Muhammad, Shaji Sanu Korumadathil, Morris Andrew Conway, Roychoudhuri Rahul, Okkenhaug Klaus, Qiu Pengfei, Mahata Bidesh

Smad4 and TGFβ1 dependent gene expression signatures in conditional intestinal adenoma, organoids and colorectal cancer

Smad4和TGFβ1依赖性基因表达特征在条件性肠腺瘤、类器官和结直肠癌中的表达

Surakhy, Mirvat; Matheson, Julia; Barnes, David J; Carter, Emma J; Hughes, Jennifer; Bühnemann, Claudia; Sanegre, Sabina; Morreau, Hans; Metz, Paul; Imianowski, Charlotte J; Hassan, Andrew Bassim

IFNγ Production by Functionally Reprogrammed Tregs Promotes Antitumor Efficacy of OX40/CD137 Bispecific Agonist Therapy

功能性重编程 Treg 产生的 IFNγ 可增强 OX40/CD137 双特异性激动剂疗法的抗肿瘤功效

Charlotte J Imianowski #, Paula Kuo #, Sarah K Whiteside, Teresa von Linde, Alexander J Wesolowski, Alberto G Conti, Alexander C Evans, Tarrion Baird, Benjamin I Morris, Nicole E Fletcher, Jie Yang, Edmund Poon, Matthew A Lakins, Masahiro Yamamoto, Neil Brewis, Michelle Morrow, Rahul Roychoudhuri

Acquisition of suppressive function by conventional T cells limits antitumor immunity upon T(reg) depletion

传统T细胞获得抑制功能后,T(reg)细胞耗竭会限制抗肿瘤免疫力。

Whiteside, Sarah K; Grant, Francis M; Alvisi, Giorgia; Clarke, James; Tang, Leqi; Imianowski, Charlotte J; Zhang, Baojie; Evans, Alexander C; Wesolowski, Alexander J; Conti, Alberto G; Yang, Jie; Lauder, Sarah N; Clement, Mathew; Humphreys, Ian R; Dooley, James; Burton, Oliver; Liston, Adrian; Alloisio, Marco; Voulaz, Emanuele; Langhorne, Jean; Okkenhaug, Klaus; Lugli, Enrico; Roychoudhuri, Rahul

BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis

BACH2限制NK细胞的成熟和功能,从而限制机体对癌症转移的免疫力。

Imianowski, Charlotte J; Whiteside, Sarah K; Lozano, Teresa; Evans, Alexander C; Benson, Jayme D; Courreges, Christina J F; Sadiyah, Firas; Lau, Colleen M; Zandhuis, Nordin D; Grant, Francis M; Schuijs, Martijn J; Vardaka, Panagiota; Kuo, Paula; Soilleux, Elizabeth J; Yang, Jie; Sun, Joseph C; Kurosaki, Tomohiro; Okkenhaug, Klaus; Halim, Timotheus Y F; Roychoudhuri, Rahul

CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function

CCR8 标记肿瘤内具有高度抑制性的 Treg 细胞,但对于这些细胞的积累和抑制功能并非必需。

Whiteside, Sarah K; Grant, Francis M; Gyori, David S; Conti, Alberto G; Imianowski, Charlotte J; Kuo, Paula; Nasrallah, Rabab; Sadiyah, Firas; Lira, Sergio A; Tacke, Frank; Eil, Robert L; Burton, Oliver T; Dooley, James; Liston, Adrian; Okkenhaug, Klaus; Yang, Jie; Roychoudhuri, Rahul

A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells

位于风险位点 11q13.5 的远端增强子促进 Treg 细胞对结肠炎的抑制作用。

Rabab Nasrallah # ,Charlotte J Imianowski # ,Lara Bossini-Castillo ,Francis M Grant ,Mikail Dogan ,Lindsey Placek ,Lina Kozhaya ,Paula Kuo ,Firas Sadiyah ,Sarah K Whiteside ,Maxwell R Mumbach ,Dafni Glinos ,Panagiota Vardaka ,Carly E Whyte ,Teresa Lozano ,Toshitsugu Fujita ,Hodaka Fujii ,Adrian Liston ,Simon Andrews ,Adeline Cozzani ,Jie Yang ,Suman Mitra ,Enrico Lugli ,Howard Y Chang ,Derya Unutmaz ,Gosia Trynka ,Rahul Roychoudhuri