Loss of TET function in T regulatory cells yields ex-Treg cells biased toward T follicular helper cells, causing autoimmune diseases through autoantibody production
Treg细胞中TET功能的丧失会导致前Treg细胞向滤泡辅助性T细胞分化,并通过自身抗体的产生引发自身免疫性疾病。
期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2026.1684023
Suzuki, Kazumasa; Arteaga-Vazquez, Leo J; Villalobos Reveles, Bruno; Hernández-Espinosa, Lot; López-Moyado, Isaac F; Onodera, Atsushi; Samaniego-Castruita, Daniela; Ay, Ferhat; Lara-Custodio, Arlet; Hogan, Patrick G; Sepulveda, Hugo; Rao, Anjana
T细胞
自身免疫性疾病
Treg
T细胞
细胞生物学
免疫/内分泌