日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Neuronal MAPT expression is mediated by long-range interactions with cis-regulatory elements

神经元MAPT的表达是通过与顺式调控元件的长程相互作用介导的。

Brianne B Rogers ,Ashlyn G Anderson ,Shelby N Lauzon ,M Natalie Davis ,Rebecca M Hauser ,Sydney C Roberts ,Ivan Rodriguez-Nunez ,Katie Trausch-Lowther ,Erin A Barinaga ,Paige I Hall ,Matthew T Knuesel ,Jared W Taylor ,Mark Mackiewicz ,Brian S Roberts ,Sara J Cooper ,Lindsay F Rizzardi ,Richard M Myers ,J Nicholas Cochran

Development of small-molecule Tau-SH3 interaction inhibitors that prevent amyloid-β toxicity and network hyperexcitability

开发预防淀粉样β蛋白毒性和网络过度兴奋的小分子 Tau-SH3 相互作用抑制剂

Jonathan R Roth, Travis Rush, Samantha J Thompson, Adam R Aldaher, Trae B Dunn, Jacob S Mesina, J Nicholas Cochran, Nicholas R Boyle, Hunter B Dean, Zhengrong Yang, Vibha Pathak, Pedro Ruiz, Mousheng Wu, Jeremy J Day, J Robert Bostwick, Mark J Suto, Corinne E Augelli-Szafran, Erik D Roberson

Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer's disease-specific cis-regulatory elements

单核多组学鉴定出 ZEB1 和 MAFB 为阿尔茨海默病特异性顺式调节元件的候选调节因子

Ashlyn G Anderson, Brianne B Rogers, Jacob M Loupe, Ivan Rodriguez-Nunez, Sydney C Roberts, Lauren M White, J Nicholas Brazell, William E Bunney, Blynn G Bunney, Stanley J Watson, J Nicholas Cochran, Richard M Myers, Lindsay F Rizzardi

MAPT expression is mediated by long-range interactions with cis-regulatory elements

MAPT 表达由与顺式调控元件的长距离相互作用介导

Brianne B Rogers, Ashlyn G Anderson, Shelby N Lauzon, M Natalie Davis, Rebecca M Hauser, Sydney C Roberts, Ivan Rodriguez-Nunez, Katie Trausch-Lowther, Erin A Barinaga, Jared W Taylor, Mark Mackiewicz, Brian S Roberts, Sara J Cooper, Lindsay F Rizzardi, Richard M Myers, J Nicholas Cochran

A neurodegenerative disease landscape of rare mutations in Colombia due to founder effects

哥伦比亚因奠基者效应而出现的罕见突变神经退行性疾病概况

Juliana Acosta-Uribe #, David Aguillón #, J Nicholas Cochran, Margarita Giraldo, Lucía Madrigal, Bradley W Killingsworth, Rijul Singhal, Sarah Labib, Diana Alzate, Lina Velilla, Sonia Moreno, Gloria P García, Amanda Saldarriaga, Francisco Piedrahita, Liliana Hincapié, Hugo E López, Nithesh Perumal, 

Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy

在 Scn1a 相关癫痫性脑病小鼠模型中,非编码变异导致毒性外显子的异常调控

Yuliya Voskobiynyk, Gopal Battu, Stephanie A Felker, J Nicholas Cochran, Megan P Newton, Laura J Lambert, Robert A Kesterson, Richard M Myers, Gregory M Cooper, Erik D Roberson, Gregory S Barsh

Alzheimer's disease risk gene BIN1 induces Tau-dependent network hyperexcitability

阿尔茨海默病风险基因 BIN1 诱导 Tau 依赖性网络过度兴奋

Yuliya Voskobiynyk #, Jonathan R Roth #, J Nicholas Cochran, Travis Rush, Nancy Vn Carullo, Jacob S Mesina, Mohammad Waqas, Rachael M Vollmer, Jeremy J Day, Lori L McMahon, Erik D Roberson

A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity

Tau-SH3 相互作用的肽抑制剂可改善淀粉样β蛋白的毒性

Travis Rush, Jonathan R Roth, Samantha J Thompson, Adam R Aldaher, J Nicholas Cochran, Erik D Roberson

PEA15 loss of function and defective cerebral development in the domestic cat

PEA15 功能丧失和家猫大脑发育缺陷

Emily C Graff, J Nicholas Cochran, Christopher B Kaelin, Kenneth Day, Heather L Gray-Edwards, Rie Watanabe, Jey W Koehler, Rebecca A Falgoust, Jeremy W Prokop, Richard M Myers, Nancy R Cox, Gregory S Barsh, Douglas R Martin; 99 Lives Consortium

Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia

神经元蜡样脂褐素沉积症基因 MFSD8 中的罕见变异是额颞叶痴呆的候选风险因素

Ethan G Geier, Mathieu Bourdenx, Nadia J Storm, J Nicholas Cochran, Daniel W Sirkis, Ji-Hye Hwang, Luke W Bonham, Eliana Marisa Ramos, Antonio Diaz, Victoria Van Berlo, Deepika Dokuru, Alissa L Nana, Anna Karydas, Maureen E Balestra, Yadong Huang, Silvia P Russo, Salvatore Spina, Lea T Grinberg, Wil