AKT-AMPKα-mTOR-dependent HIF-1α Activation is a New Therapeutic Target for Cancer Treatment: A Novel Approach to Repositioning the Antidiabetic Drug Sitagliptin for the Management of Hepatocellular Carcinoma
AKT-AMPKα-mTOR 依赖的 HIF-1α 激活是癌症治疗的新靶点:重新定位抗糖尿病药物西他列汀用于治疗肝细胞癌的新方法
期刊:Frontiers in Pharmacology
影响因子:4.4
doi:10.3389/fphar.2021.720173
Eslam E Abd El-Fattah, Sameh Saber, Mahmoud E Youssef, Hanan Eissa, Eman El-Ahwany, Noha A Amin, Mohammed Alqarni, Gaber El-Saber Batiha, Ahmad J Obaidullah, Mohamed M Y Kaddah, Ahmed Gaafar Ahmed Gaafar, Ahmed A E Mourad, Gomaa Mostafa-Hedeab, Amir Mohamed Abdelhamid
代谢
信号转导
糖尿病
肝癌
其它细胞
PI3K/Akt
mTOR