日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer

衰老定义了肌成纤维细胞的一个独特亚群,该亚群在胰腺癌中协调免疫抑制

Belle, Jad I; Sen, Devashish; Baer, John M; Liu, Xiuting; Lander, Varintra E; Ye, Jiayu; Sells, Blake E; Knolhoff, Brett L; Faiz, Ahmad; Kang, Liang-I; Qian, Guhan; Fields, Ryan C; Ding, Li; Kim, Hyun; Provenzano, Paolo P; Stewart, Sheila A; DeNardo, David G

Senescent CAFs Mediate Immunosuppression and Drive Breast Cancer Progression

衰老 CAF 介导免疫抑制并促进乳腺癌进展

Jiayu Ye, John M Baer, Douglas V Faget, Vasilios A Morikis, Qihao Ren, Anupama Melam, Ana Paula Delgado, Xianmin Luo, Satarupa Mullick Bagchi, Jad I Belle, Edward Campos, Michael Friedman, Deborah J Veis, Erik S Knudsen, Agnieszka K Witkiewicz, Scott Powers, Gregory D Longmore, David G DeNardo, Shei

Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy

基质和治疗诱导的巨噬细胞增殖促进 PDAC 进展和对先天免疫疗法的敏感性

Chong Zuo, John M Baer, Brett L Knolhoff, Jad I Belle, Xiuting Liu, Angela Alarcon De La Lastra, Christina Fu, Graham D Hogg, Natalie L Kingston, Marcus A Breden, Paarth B Dodhiawala, Daniel Cui Zhou, Varintra E Lander, C Alston James, Li Ding, Kian-Huat Lim, Ryan C Fields, William G Hawkins, Jason

Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade

通过FAK抑制进行基质重编程可克服辐射抗性,从而启动免疫反应并对检查点阻断产生反应。

Varintra E Lander ,Jad I Belle ,Natalie L Kingston ,John M Herndon ,Graham D Hogg ,Xiuting Liu ,Liang-I Kang ,Brett L Knolhoff ,Savannah J Bogner ,John M Baer ,Chong Zuo ,Nicholas C Borcherding ,Daniel P Lander ,Cedric Mpoy ,Jalen Scott ,Michael Zahner ,Buck E Rogers ,Julie K Schwarz ,Hyun Kim # ,David G DeNardo #

Defactinib, Pembrolizumab, and Gemcitabine in Patients with Advanced Treatment Refractory Pancreatic Cancer: A Phase I Dose Escalation and Expansion Study

Defactinib、Pembrolizumab 和吉西他滨治疗晚期难治性胰腺癌患者:一项 I 期剂量递增和扩展研究

Wang-Gillam, Andrea; Lim, Kian-Huat; McWilliams, Robert; Suresh, Rama; Lockhart, Albert C; Brown, Amberly; Breden, Marcus; Belle, Jad I; Herndon, John; Bogner, Savannah J; Pedersen, Katrina; Tan, Benjamin; Boice, Nicholas; Acharya, Abhi; Abdiannia, Mina; Gao, Feng; Yoon, Harry H; Zhu, Mojun; Trikalinos, Nikolaos A; Ratner, Lee; Aranha, Olivia; Hawkins, William G; Herzog, Brett H; DeNardo, David G

Breast cancer-derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment

乳腺癌来源的GM-CSF调节髓系细胞中的精氨酸酶1,从而促进免疫抑制性微环境的形成。

Su, Xinming; Xu, Yalin; Fox, Gregory C; Xiang, Jingyu; Kwakwa, Kristin A; Davis, Jennifer L; Belle, Jad I; Lee, Wen-Chih; Wong, Wing H; Fontana, Francesca; Hernandez-Aya, Leonel F; Kobayashi, Takayuki; Tomasson, Helen M; Su, Junyi; Bakewell, Suzanne J; Stewart, Sheila A; Egbulefu, Christopher; Karmakar, Partha; Meyer, Melisa A; Veis, Deborah J; DeNardo, David G; Lanza, Gregory M; Achilefu, Samuel; Weilbaecher, Katherine N

p53-dependent induction of P2X7 on hematopoietic stem and progenitor cells regulates hematopoietic response to genotoxic stress

p53 依赖性 P2X7 对造血干细胞和祖细胞的诱导调节造血对基因毒性应激的反应

Lin Tze Tung #, HanChen Wang #, Jad I Belle, Jessica C Petrov, David Langlais, Anastasia Nijnik

Loss of MYSM1 inhibits the oncogenic activity of cMYC in B cell lymphoma

MYSM1 的缺失抑制了 cMYC 在 B 细胞淋巴瘤中的致癌活性

Lin, Yun Hsiao; Wang, HanChen; Fiore, Amanda; Förster, Michael; Tung, Lin Tze; Belle, Jad I; Robert, Francis; Pelletier, Jerry; Langlais, David; Nijnik, Anastasia

Osterix-Cre marks distinct subsets of CD45- and CD45+ stromal populations in extra-skeletal tumors with pro-tumorigenic characteristics

Osterix-Cre 可标记骨外肿瘤中具有促肿瘤特性的 CD45- 和 CD45+ 基质细胞亚群。

Biancamaria Ricci ,Eric Tycksen ,Hamza Celik ,Jad I Belle ,Francesca Fontana ,Roberto Civitelli ,Roberta Faccio

MYSM1 maintains ribosomal protein gene expression in hematopoietic stem cells to prevent hematopoietic dysfunction

MYSM1维持造血干细胞中核糖体蛋白基因表达以防止造血功能障碍

Jad I Belle, HanChen Wang, Amanda Fiore, Jessica C Petrov, Yun Hsiao Lin, Chu-Han Feng, Thi Tuyet Mai Nguyen, Jacky Tung, Philippe M Campeau, Uta Behrends, Theresa Brunet, Gloria Sarah Leszinski, Philippe Gros, David Langlais, Anastasia Nijnik