日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Differential effects on acetaminophen-induced nephrotoxicity and liver injury following modulation of glutathione resynthesis

调节谷胱甘肽再合成对乙酰氨基酚引起的肾毒性和肝损伤产生不同的影响

Etemadi, Yasaman; Akakpo, Jephte Y; Fields, Timothy A; Ramachandran, Anup; Jaeschke, Hartmut

Dysregulation of xenobiotic metabolism and mitochondrial dysfunction exacerbate acetaminophen-induced hepatotoxicity in human antigen R-deficient male mice

异生物质代谢紊乱和线粒体功能障碍会加剧人抗原R缺陷雄性小鼠对乙酰氨基酚诱导的肝毒性。

Eppler, Natalie; Jones, Elizabeth; Ahamed, Forkan; Raja, Naren; Akakpo, Jephte Y; Lebofsky, Margitta; He, Lily; Vats, Ira; Ghosh, Priyanka; Yu, Yifan; Thomas, Kaitlyn; McCoin, Colin; Thyfault, John; Wu, Xiaoqing; Xu, Liang; Cui, Wei; Wang, Rong; Jaeschke, Hartmut; Zhang, Yuxia

Iron supplementation switches mode of cell death to ferroptosis during acetaminophen-induced liver injury in mice rendering it resistant to N-acetylcysteine.

在对乙酰氨基酚引起的小鼠肝损伤期间,补充铁剂可将细胞死亡方式转变为铁死亡,从而使其对 N-乙酰半胱氨酸产生抗性。

Adelusi Olamide B, Venkatraman Aparna, Akakpo Jephte Y, Ramachandran Anup, Jaeschke Hartmut

4-Methylpyrazole-mediated inhibition of cytochrome P450 2E1 protects renal epithelial cells, but not bladder cancer cells, from cisplatin toxicity.

4-甲基吡唑介导的细胞色素 P450 2E1 抑制作用可保护肾上皮细胞免受顺铂毒性,但不能保护膀胱癌细胞免受顺铂毒性

Akakpo Jephte Y, Abbott Erika, Woolbright Benjamin L, Ramachandran Anup, Schnellmann Rick G, Wallace Darren P, Taylor John A

Mixed lineage kinase domain-like protein deficiency exacerbates early injury in a mouse model of acetaminophen hepatotoxicity.

混合谱系激酶结构域样蛋白缺乏会加剧对乙酰氨基酚肝毒性小鼠模型中的早期损伤

Sanchez-Guerrero Giselle, Umbaugh David S, Smith Sawyer H, Akakpo Jephte Y, Jaeschke Hartmut, Ramachandran Anup

Clinically relevant therapeutic approaches against acetaminophen hepatotoxicity and acute liver failure

针对对乙酰氨基酚肝毒性和急性肝衰竭的临床相关治疗方法

Ramachandran, Anup; Akakpo, Jephte Y; Curry, Steven C; Rumack, Barry H; Jaeschke, Hartmut

The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice

促血小板生成素类似物JNJ-26366821可减轻对乙酰氨基酚诱导的小鼠肝损伤的后期损伤,并加速肝脏恢复。

Olamide B Adelusi ,Jephte Y Akakpo ,Gary Eichenbaum ,Ejaz Sadaff ,Anup Ramachandran ,Hartmut Jaeschke

High-Dose Acetaminophen with Concurrent CYP2E1 Inhibition Has Profound Anticancer Activity without Liver Toxicity

高剂量对乙酰氨基酚与 CYP2E1 同时抑制具有显著的抗癌活性,且无肝毒性

Allyn Bryan, Pavani Pingali, Anthony Faber, Joseph Landry, Jephte Y Akakpo, Hartmut Jaeschke, Howard Li, Won Sok Lee, Lauren May, Bhaumik Patel, Alex Neuwelt

Effect of ferroptosis inhibitors in a murine model of acetaminophen-induced liver injury

铁死亡抑制剂对乙酰氨基酚诱导的小鼠肝损伤模型的影响

Adelusi, Olamide B; Etemadi, Yasaman; Akakpo, Jephte Y; Ramachandran, Anup; Jaeschke, Hartmut

Lack of mitochondrial Cyp2E1 drives acetaminophen-induced ER stress-mediated apoptosis in mouse and human kidneys: Inhibition by 4-methylpyrazole but not N-acetylcysteine

线粒体 Cyp2E1 缺乏导致小鼠和人类肾脏中乙酰氨基酚诱导的内质网应激介导的细胞凋亡:4-甲基吡唑抑制,但 N-乙酰半胱氨酸不抑制

Jephte Y Akakpo, Anup Ramachandran, Barry H Rumack, Darren P Wallace, Hartmut Jaeschke