日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19

抑制线粒体丙酮酸载体可同时减轻新冠肺炎中的过度炎症和高血糖症。

Bibo Zhu ,Xiaoqin Wei ,Harish Narasimhan ,Wei Qian ,Ruixuan Zhang ,In Su Cheon ,Yue Wu ,Chaofan Li ,Russell G Jones ,Mark H Kaplan ,Robert A Vassallo ,Thomas J Braciale ,Lindsay Somerville ,Jerry R Colca ,Akhilesh Pandey ,Patrick E H Jackson ,Barbara J Mann ,Connie M Krawczyk ,Jeffrey M Sturek ,Jie Sun

Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism

线粒体丙酮酸载体抑制引发代谢串扰,刺激支链氨基酸分解代谢

Daniel Ferguson, Sophie J Eichler, Nicole K H Yiew, Jerry R Colca, Kevin Cho, Gary J Patti, Trevor M Shew, Andrew J Lutkewitte, Sandip Mukherjee, Kyle S McCommis, Natalie M Niemi, Brian N Finck

Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide

新型胰岛素增敏剂 MSDC-0602K 单独使用或与利拉鲁肽联合使用可改善小鼠的胰岛素血症和脂肪肝疾病

Dakota R Kamm, Kelly D Pyles, Martin C Sharpe, Laura N Healy, Jerry R Colca, Kyle S McCommis

Inhibiting the mitochondrial pyruvate carrier does not ameliorate synucleinopathy in the absence of inflammation or metabolic deficits

在没有炎症或代谢缺陷的情况下,抑制线粒体丙酮酸载体并不能改善突触核蛋白病

Wouter Peelaerts, Liza Bergkvist, Sonia George, Michaela Johnson, Lindsay Meyerdirk, Emily Schulz, Jennifer A Steiner, Zachary Madaj, Jiyan Ma, Katelyn Becker, K Peter R Nilsson, Jerry R Colca, Patrik Brundin

Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis

靶向线粒体丙酮酸载体可减轻非酒精性脂肪性肝炎小鼠模型中的纤维化

Kyle S McCommis, Wesley T Hodges, Elizabeth M Brunt, Ilke Nalbantoglu, William G McDonald, Christopher Holley, Hideji Fujiwara, Jean E Schaffer, Jerry R Colca, Brian N Finck

The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism

胰岛素增敏剂的有益代谢作用不会因线粒体丙酮酸载体 2 低等位基因缺陷而减弱

Patrick A Vigueira, Kyle S McCommis, Wesley T Hodges, George G Schweitzer, Serena L Cole, Lalita Oonthonpan, Eric B Taylor, William G McDonald, Rolf F Kletzien, Jerry R Colca, Brian N Finck

Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins

噻唑烷二酮胰岛素增敏剂 (mTOT) 的线粒体靶点的鉴定——与新鉴定的线粒体丙酮酸载体蛋白的关系

Jerry R Colca, William G McDonald, Gregory S Cavey, Serena L Cole, Danielle D Holewa, Angela S Brightwell-Conrad, Cindy L Wolfe, Jean S Wheeler, Kristin R Coulter, Peter M Kilkuskie, Elena Gracheva, Yulia Korshunova, Michelle Trusgnich, Robert Karr, Sandra E Wiley, Ajit S Divakaruni, Anne N Murphy, 

Novel insulin sensitizer modulates nutrient sensing pathways and maintains β-cell phenotype in human islets

新型胰岛素增敏剂调节营养传感途径并维持人类胰岛β细胞表型

Nidhi Rohatgi, Haytham Aly, Connie A Marshall, William G McDonald, Rolf F Kletzien, Jerry R Colca, Michael L McDaniel

Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione

新型过氧化物酶体增殖激活受体γ-保留噻唑烷二酮可改善肥胖小鼠的胰岛素抵抗和代谢紊乱

Zhouji Chen, Patrick A Vigueira, Kari T Chambers, Angela M Hall, Mayurranjan S Mitra, Nathan Qi, William G McDonald, Jerry R Colca, Rolf F Kletzien, Brian N Finck