日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Data-driven protease engineering by DNA-recording and epistasis-aware machine learning.

基于DNA记录和上位性感知机器学习的数据驱动型蛋白酶工程

Huber Lukas, Kucera Tim, Höllerer Simon, Borgwardt Karsten, Panke Sven, Jeschek Markus

Of Revolutions and Roadblocks: The Emerging Role of Machine Learning in Biocatalysis

革命与障碍:机器学习在生物催化领域的新兴作用

Vornholt, Tobias; Stockinger, Peter; Mutný, Mojmír; Jeschek, Markus; Nestl, Bettina; Oberdorfer, Gustav; Osuna, Silvia; Pleiss, Jürgen; Welner, Ditte Hededam; Krause, Andreas; Buller, Rebecca; Ward, Thomas R

Permeabilisation of the Outer Membrane of Escherichia coli for Enhanced Transport of Complex Molecules.

提高大肠杆菌外膜的通透性以增强复杂分子的运输

Casas-Rodrigo Ivan, Vornholt Tobias, Castiglione Kathrin, Roberts Tania Michelle, Jeschek Markus, Ward Thomas R, Panke Sven

Enhanced Sequence-Activity Mapping and Evolution of Artificial Metalloenzymes by Active Learning

通过主动学习增强序列-活性映射和人工金属酶的进化

Vornholt, Tobias; Mutný, Mojmír; Schmidt, Gregor W; Schellhaas, Christian; Tachibana, Ryo; Panke, Sven; Ward, Thomas R; Krause, Andreas; Jeschek, Markus

Ultradeep characterisation of translational sequence determinants refutes rare-codon hypothesis and unveils quadruplet base pairing of initiator tRNA and transcript

翻译序列决定因子的超深度表征驳斥了稀有密码子假说,并揭示了启动 tRNA 和转录本的四联体碱基配对

Simon Höllerer, Markus Jeschek

Systematic engineering of artificial metalloenzymes for new-to-nature reactions

人工金属酶的系统工程用于新自然反应

Tobias Vornholt, Fadri Christoffel, Michela M Pellizzoni, Sven Panke, Thomas R Ward, Markus Jeschek

Large-scale DNA-based phenotypic recording and deep learning enable highly accurate sequence-function mapping

大规模基于 DNA 的表型记录和深度学习可实现高度精确的序列功能映射

Simon Höllerer #, Laetitia Papaxanthos #, Anja Cathrin Gumpinger, Katrin Fischer, Christian Beisel, Karsten Borgwardt, Yaakov Benenson, Markus Jeschek

Chemo-enzymatic cascades to produce cycloalkenes from bio-based resources

化学酶级联从生物基资源中生产环烯烃

Shuke Wu, Yi Zhou, Daniel Gerngross, Markus Jeschek, Thomas R Ward

Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort

合理精简的组合路径优化库可最大限度地减少实验工作量

Jeschek, Markus; Gerngross, Daniel; Panke, Sven

Paternal heat exposure causes DNA methylation and gene expression changes of Stat3 in Wild guinea pig sons.

父亲的热暴露会导致野生豚鼠雄性后代 Stat3 的 DNA 甲基化和基因表达改变

Weyrich Alexandra, Benz Stephanie, Karl Stephan, Jeschek Marie, Jewgenow Katarina, Fickel Joerns