Kurarinone alleviates hemin-induced neuroinflammation and microglia-mediated neurotoxicity by shifting microglial M1/M2 polarization via regulating the IGF1/PI3K/Akt signaling.

Kurarinone 通过调节 IGF1/PI3K/Akt 信号通路，改变小胶质细胞 M1/M2 极化，从而减轻血红素诱导的神经炎症和小胶质细胞介导的神经毒性