日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Diselenide-bridged dual-action nanoscavengers drive fasting-boosted BBB penetration and ROS-responsive resveratrol delivery for synergistic ischemic stroke therapy.

二硒桥联双效纳米清除剂可促进禁食增强的血脑屏障穿透和 ROS 响应性白藜芦醇递送,从而实现协同缺血性中风治疗。

Chen Qing, Zhang Qian, Wang Jin, Xiong Xiaoxing, Luo Baiyi, Chen Yu, Zhang Jinrong, Zhao Min, Gu Lijuan, Tian Jian

The G9a-TRIM21 axis exacerbates diabetic renal ischemia-reperfusion injury by inducing methylation-dependent ubiquitination and degradation of FoxO3a to promote oxidative stress and pyroptosis.

G9a-TRIM21 轴通过诱导 FoxO3a 的甲基化依赖性泛素化和降解,促进氧化应激和细胞焦亡,从而加剧糖尿病肾脏缺血再灌注损伤。

Zheng Qingyuan, Qin Xuke, Huang Shiyu, Yan Zhiwei, Liu Jin, Xiong Yufeng, Zhao Xiaojie, Ni Xinmiao, Mei Haonan, Jian Jun, Wang Jingsong, Lu Qianxue, Chen Zhiyuan, Liu Xiuheng, Wan Shanshan, Liu Hao, Wang Lei

Family history of type 2 diabetes delays development of type 1 diabetes in TEDDY children with islet autoimmunity

2型糖尿病家族史会延缓TEDDY综合征患儿(伴有胰岛自身免疫)发生1型糖尿病。

Veijola, Riitta; Tamura, Roy N; Clasen, Joanna L; Elding Larsson, Helena; Warncke, Katharina; Steck, Andrea K; Haller, Michael J; Jonsdottir, Berglind; Akolkar, Beena; Hagopian, William A; Rewers, Marian J; She, Jin-Xiong; Ziegler, Anette-Gabriele; Krischer, Jeffrey P; Toppari, Jorma

Editorial: Regulation and mechanism of plant metabolites on hyperuricemia

社论:植物代谢物对高尿酸血症的调控及其机制

Wan, Yin; Qian, Jin; Xiong, Tao; Lu, Jun

Structure-guided design of picomolar-level macrocyclic TRPC5 channel inhibitors with antidepressant activity

结构导向设计具有抗抑郁活性的皮摩尔级大环TRPC5通道抑制剂

Che, Tong; Chen, Yixiang; Cheng, Xinyu; Hu, Han; Wu, Xiaoyun; Zhang, Yuting; Yang, Xiaoqiang; Liu, Yinzhen; Liu, Hui; Nan, Weiwei; Wan, Shuangyan; Yang, Mingxing; Zeng, Bo; Li, Jian; Zhang, Jin; Xiong, Bing

Repurposing a detrimental antibody epitope as targeted therapeutics for sepsis and rheumatoid arthritis

将有害抗体表位重新用于治疗脓毒症和类风湿性关节炎

Chen, Wei-Qiang; Lou, Li; Qiang, Xiao-Ling; Zhu, Cassie Shu; Li, Jian-Hua; Chen, Shu-Jin; Xiong, Brian; Yang, Huan; Wang, Ping; Tracey, Kevin J; Wang, Hai-Chao

Mature tertiary lymphoid structures evoke intra-tumoral T and B cell responses via progenitor exhausted CD4(+) T cells in head and neck cancer

在头颈癌中,成熟的三级淋巴结构通过耗竭的祖细胞 CD4(+) T 细胞诱导肿瘤内 T 细胞和 B 细胞反应。

Li, Hao; Zhang, Meng-Jie; Zhang, Boxin; Lin, Wen-Ping; Li, Shu-Jin; Xiong, Dian; Wang, Qing; Wang, Wen-Da; Yang, Qi-Chao; Huang, Cong-Fa; Deng, Wei-Wei; Sun, Zhi-Jun

m(6)A Reader hnRNPA2B1 Modulates Late Pachytene Progression in Male Meiosis Through Post-Transcriptional Control.

m(6)A 阅读器 hnRNPA2B1 通过转录后控制调节雄性减数分裂中晚期粗线期进程。

Yin Lisha, Zhang Yuting, Zhang Bingqian, Zhang Jin, Xiong Mengneng, Jiang Nan, Xiao Jinxin, Gao Huihui, Xiong Wenjing, Wang Xiaoli, Wang Fengli, Yuan Shuiqiao

Synapsin III promotes neuronal-like transdifferentiation of glioblastoma stem cells by disrupting JAG1-Notch1 interaction

突触蛋白III通过破坏JAG1-Notch1相互作用促进胶质母细胞瘤干细胞向神经元样转分化。

Deng, Yilin; Yuan, Zheng; Jin, Xiong; Wang, Zekun; Gong, Rui; Ren, Shuai; Park, Jong Bae; Shi, Bingyang; Yin, Jinlong

MAGL targeted PROTAC degrader simultaneously enhances P53 for synergistic treatment of glioblastoma stem cell.

MAGL靶向PROTAC降解剂同时增强P53,以协同治疗胶质母细胞瘤干细胞

Yuan Zheng, Guo Meixia, Zhang Yue, Deng Yilin, Sun Biao, Hou Yaning, Wang Xin, Jin Xiong, Liu Yang, Shi Bingyang, Yin Jinlong