日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Transcription factor switching drives subtype-specific pancreatic cancer

转录因子转换驱动亚型特异性胰腺癌

Shalini V Rao,Lisa Young,Danya Cheeseman,Sean Flynn,Niklas Krebs,Dominique-Laurent Couturier,Stephanie Mack,Rebecca Brais,Jill Temple,Amy Smith,Evangelia Papachristou,Catarina Pelicano,Chandra Sekhar Reddy Chilamakuri,Krzysztof Herka,Hideo Baba,Luay Farah,Phyllis F Cheung,Jens Siveke,Stéphane Guerrier,Luca Insolia,Michael Gill,Emily Archer Goode,Steven Kupczak,Yi Cheng,Giacomo Borsari,Duncan Jodrell,Clive D'Santos,Alasdair Russell,Barbara T Grünwald,Eva Serrao,Igor Chernukhin,Jason S Carroll

First-in-Human Study to Evaluate the Safety and Efficacy of Anti-GDF15 Antibody AZD8853 in Patients with Advanced/Metastatic Solid Tumors

首次人体研究评估抗GDF15抗体AZD8853在晚期/转移性实体瘤患者中的安全性和有效性

Carneiro, Benedito A; Gbolahan, Olumide B; Abdul Razak, Albiruni Abdul; Hilton, John F; Lambert, Arthur W; Hood, John; Pluta, Michael; Bragulat, Veronique; Sanai, Elhan; Kumar, Rakesh; Jodrell, Duncan I; LoRusso, Patricia M

Intratumoral antigen signaling traps CD8(+) T cells to confine exhaustion to the tumor site

肿瘤内抗原信号传导会捕获 CD8(+) T 细胞,从而将 T 细胞耗竭限制在肿瘤部位。

Takahashi, Munetomo; So, Tsz Y; Chamberlain-Evans, Vitalina; Hughes, Robert; Yam-Puc, Juan Carlos; Kania, Katarzyna; Ruhle, Michelle; Mann, Tiffeney; Schuijs, Martijn J; Coupland, Paul; Naisbitt, Dean; Halim, Timotheus Y F; Lyons, Paul A; Lio, Pietro; Roychoudhuri, Rahul; Okkenhaug, Klaus; Adams, David J; Smith, Ken G C; Jodrell, Duncan I; Chapman, Michael A; Thaventhiran, James E D

Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma

通过确定细胞外腺苷的空间分布,揭示了胰腺导管腺癌中髓系依赖性免疫抑制微环境。

Vincenzo Graziano ,Andreas Dannhorn # ,Heather Hulme # ,Kate Williamson # ,Hannah Buckley ,Saadia A Karim ,Matthew Wilson ,Sheng Y Lee ,Brajesh P Kaistha ,Sabita Islam ,James E D Thaventhiran ,Frances M Richards ,Richard Goodwin ,Rebecca Brais ,Jennifer P Morton ,Simon J Dovedi ,Alwin G Schuller ,Jim Eyles ,Duncan I Jodrell

Size-tuneable and immunocompatible polymer nanocarriers for drug delivery in pancreatic cancer

尺寸可调且免疫相容的聚合物纳米载体用于胰腺癌药物输送

Andrea Bistrović Popov, Francesca Melle, Emily Linnane, Cristina González-López, Ishtiaq Ahmed, Badri Parshad, Christoph O Franck, Hassan Rahmoune, Frances M Richards, Daniel Muñoz-Espín, Duncan I Jodrell, David Fairen-Jimenez, Ljiljana Fruk

Early Neutrophilia Marked by Aerobic Glycolysis Sustains Host Metabolism and Delays Cancer Cachexia

以有氧糖酵解为标志的早期中性粒细胞增多症可维持宿主代谢并延缓癌症恶病质

Michele Petruzzelli, Miriam Ferrer, Martijn J Schuijs, Sam O Kleeman, Nicholas Mourikis, Zoe Hall, David Perera, Shwethaa Raghunathan, Michele Vacca, Edoardo Gaude, Michael J Lukey, Duncan I Jodrell, Christian Frezza, Erwin F Wagner, Ashok R Venkitaraman, Timotheus Y F Halim, Tobias Janowitz

Quantifying cell cycle-dependent drug sensitivities in cancer using a high throughput synchronisation and screening approach

使用高通量同步和筛选方法量化癌症中细胞周期依赖性药物敏感性

Timothy I Johnson, Christopher J Minteer, Daniel Kottmann, Charles R Dunlop, Sandra Bernaldo de Quirós Fernández, Larissa S Carnevalli, Yann Wallez, Alan Lau, Frances M Richards, Duncan I Jodrell

Mechanisms Underlying Vascular Endothelial Growth Factor Receptor Inhibition-Induced Hypertension: The HYPAZ Trial

血管内皮生长因子受体抑制诱发高血压的潜在机制:HYPAZ 试验

Kaisa M Mäki-Petäjä #, Adam McGeoch #, Lucy L Yang, Annette Hubsch, Carmel M McEniery, Paul A R Meyer, Fraz Mir, Parag Gajendragadkar, Nicola Ramenatte, Gayathri Anandappa, Sara Santos Franco, Simon J Bond, Carola-Bibiane Schönlieb, Yoeri Boink, Christoph Brune, Ian B Wilkinson, Duncan I Jodrell, Jo

T Cell-Mediated Antitumor Immunity Cooperatively Induced By TGFβR1 Antagonism and Gemcitabine Counteracts Reformation of the Stromal Barrier in Pancreatic Cancer

TGFβR1拮抗剂和吉西他滨协同诱导的T细胞介导的抗肿瘤免疫可抵消胰腺癌基质屏障的重建

Dandan Li ,Nicholas Schaub ,Theresa M Guerin ,Tashinga E Bapiro ,Frances M Richards ,Vicky Chen ,Keyur Talsania ,Parimal Kumar ,Debra J Gilbert ,Jerome J Schlomer ,Seong-Jin Kim ,Rebecca Sorber ,Yaroslav Teper ,Wendy Bautista ,Claudia Palena ,Chan-Young Ock ,Duncan I Jodrell ,Nathan Pate ,Monika Mehta ,Yongmei Zhao ,Serguei Kozlov ,Udo Rudloff

Scheduling nab-paclitaxel combined with gemcitabine as first-line treatment for metastatic pancreatic adenocarcinoma

将白蛋白结合型紫杉醇联合吉西他滨作为转移性胰腺腺癌的一线治疗方案

Corrie, P G; Qian, W; Basu, B; Valle, J W; Falk, S; Lwuji, C; Wasan, H; Palmer, D; Scott-Brown, M; Wadsley, J; Arif, S; Bridgewater, J; Propper, D; Gillmore, R; Gopinathan, A; Skells, R; Bundi, P; Brais, R; Dalchau, K; Bax, L; Chhabra, A; Machin, A; Dayim, A; McAdam, K; Cummins, S; Wall, L; Ellis, R; Anthoney, A; Evans, J; Ma, Y T; Isherwood, C; Neesse, A; Tuveson, D; Jodrell, D I