日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Neurosteroid Modulation of Synaptic and Extrasynaptic GABAA Receptors of the Mouse Nucleus Accumbens

神经类固醇对小鼠伏隔核突触和突触外 GABAA 受体的调节

Scott J Mitchell, Grant D Phillips, Becks Tench, Yunkai Li, Delia Belelli, Stephen J Martin, Jerome D Swinny, Louise Kelly, John R Atack, Michael Paradowski, Jeremy J Lambert

Quantitative measurement of changes in amyloid-beta(40) in the rat brain and cerebrospinal fluid following treatment with the gamma-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide]

使用 γ-分泌酶抑制剂 LY-411575 [N2-[(2S)-2-(3,5-二氟苯基)-2-羟基乙酰基]-N1-[(7S)-5-甲基-6-氧代-6,7-二氢-5H-二苯并[b,d]氮杂卓-7-基]-L-丙氨酰胺] 治疗后,定量测量大鼠脑和脑脊液中淀粉样蛋白-β(40) 的变化

Jonathan D Best, Mark T Jay, Franklin Otu, Jerome Ma, Alan Nadin, Semantha Ellis, Huw D Lewis, Christine Pattison, Michael Reilly, Timothy Harrison, Mark S Shearman, Toni L Williamson, John R Atack

A comparative assessment of gamma-secretase activity in transgenic and non-transgenic rodent brain

转基因和非转基因啮齿动物脑中γ-分泌酶活性的比较评估

Julian L Goggi, Huw D Lewis, Joanie Mok, Tim Harrison, Mark S Shearman, John R Atack, Jonathan D Best

A toolkit for the identification of NEAT1_2/paraspeckle modulators

用于识别 NEAT1_2/paraspeckle 调节剂的工具包

Haiyan An, Karen T Elvers, Jason A Gillespie, Kimberley Jones, John R Atack, Olivera Grubisha, Tatyana A Shelkovnikova

Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity

小分子 LIMK1/2 抑制剂的比较分析:化学合成、生物化学和细胞活性

Ross Collins, Hyunah Lee, D Heulyn Jones, Jonathan M Elkins, Jason A Gillespie, Carys Thomas, Alex G Baldwin, Kimberley Jones, Loren Waters, Marie Paine, John R Atack, Simon E Ward, Olivera Grubisha, David W Foley

Exploring Calbindin-IMPase fusion proteins structure and activity

探索 Calbindin-IMPase 融合蛋白的结构和活性

James W Noble, John R Atack

A Biophysical Approach to the Identification of Novel ApoE Chemical Probes

鉴定新型 ApoE 化学探针的生物物理方法

Lucas Kraft, Louise C Serpell, John R Atack

The Molecular Basis for Apolipoprotein E4 as the Major Risk Factor for Late-Onset Alzheimer's Disease

载脂蛋白 E4 作为晚发性阿尔茨海默病主要危险因素的分子基础

Ana-Caroline Raulin, Lucas Kraft, Youssra K Al-Hilaly, Wei-Feng Xue, John E McGeehan, John R Atack, Louise Serpell

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2

酪氨酰 DNA 磷酸二酯酶 2 的 DNA 竞争性小分子抑制剂的作用方式

Peter Hornyak, Trevor Askwith, Sarah Walker, Emilia Komulainen, Michael Paradowski, Lewis E Pennicott, Edward J Bartlett, Nigel C Brissett, Ali Raoof, Mandy Watson, Allan M Jordan, Donald J Ogilvie, Simon E Ward, John R Atack, Laurence H Pearl, Keith W Caldecott, Antony W Oliver

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors

开发基于寡核苷酸的荧光检测方法,用于鉴定酪氨酰-DNA 磷酸二酯酶 1 (TDP1) 抑制剂

Sarah Walker, Cornelia Meisenberg, Rachel A Bibby, Trevor Askwith, Gareth Williams, Frauke H Rininsland, Laurence H Pearl, Antony W Oliver, Sherif El-Khamisy, Simon Ward, John R Atack