日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Development of small-molecule Tau-SH3 interaction inhibitors that prevent amyloid-β toxicity and network hyperexcitability

开发预防淀粉样β蛋白毒性和网络过度兴奋的小分子 Tau-SH3 相互作用抑制剂

Jonathan R Roth, Travis Rush, Samantha J Thompson, Adam R Aldaher, Trae B Dunn, Jacob S Mesina, J Nicholas Cochran, Nicholas R Boyle, Hunter B Dean, Zhengrong Yang, Vibha Pathak, Pedro Ruiz, Mousheng Wu, Jeremy J Day, J Robert Bostwick, Mark J Suto, Corinne E Augelli-Szafran, Erik D Roberson

Apolipoprotein E Induces Lipid Accumulation Through Dgat2 That Is Prevented with Time-Restricted Feeding in Drosophila

载脂蛋白 E 通过 Dgat2 诱导脂质积累,而限时喂养可阻止果蝇的脂质积累

Ruan C M Moraes, Jonathan R Roth, Hailey Mao, Savannah R Crawley, Brittney P Xu, John C Watson, Girish C Melkani

Delivering progranulin to neuronal lysosomes protects against excitotoxicity

将前颗粒蛋白递送至神经元溶酶体可防止兴奋毒性

Skylar E Davis, Jonathan R Roth, Qays Aljabi, Ahmad R Hakim, Katherine E Savell, Jeremy J Day, Andrew E Arrant

Alzheimer's disease risk gene BIN1 induces Tau-dependent network hyperexcitability

阿尔茨海默病风险基因 BIN1 诱导 Tau 依赖性网络过度兴奋

Yuliya Voskobiynyk #, Jonathan R Roth #, J Nicholas Cochran, Travis Rush, Nancy Vn Carullo, Jacob S Mesina, Mohammad Waqas, Rachael M Vollmer, Jeremy J Day, Lori L McMahon, Erik D Roberson

A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity

Tau-SH3 相互作用的肽抑制剂可改善淀粉样β蛋白的毒性

Travis Rush, Jonathan R Roth, Samantha J Thompson, Adam R Aldaher, J Nicholas Cochran, Erik D Roberson

Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations

由于前颗粒蛋白突变导致额颞叶痴呆症中 β-葡萄糖脑苷脂酶活性和加工受损

Andrew E Arrant, Jonathan R Roth, Nicholas R Boyle, Shreya N Kashyap, Madelyn Q Hoffmann, Charles F Murchison, Eliana Marisa Ramos, Alissa L Nana, Salvatore Spina, Lea T Grinberg, Bruce L Miller, William W Seeley, Erik D Roberson

Association of Velopharyngeal Insufficiency With Quality of Life and Patient-Reported Outcomes After Speech Surgery

腭咽闭合不全与言语手术后生活质量和患者报告结局的相关性

Bhuskute, Aditi; Skirko, Jonathan R; Roth, Christina; Bayoumi, Ahmed; Durbin-Johnson, Blythe; Tollefson, Travis T