日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A model of human neural networks reveals NPTX2 pathology in ALS and FTLD

人类神经网络模型揭示了肌萎缩侧索硬化症(ALS)和额颞叶痴呆(FTLD)中的NPTX2病理。

Marian Hruska-Plochan,Vera I Wiersma #,Katharina M Betz #,Izaskun Mallona #,Silvia Ronchi #,Zuzanna Maniecka,Eva-Maria Hock,Elena Tantardini,Florent Laferriere,Sonu Sahadevan,Vanessa Hoop,Igor Delvendahl,Manuela Pérez-Berlanga,Beatrice Gatta,Martina Panatta,Alexander van der Bourg,Dasa Bohaciakova,Puneet Sharma,Laura De Vos,Karl Frontzek,Adriano Aguzzi,Tammaryn Lashley,Mark D Robinson,Theofanis Karayannis,Martin Mueller,Andreas Hierlemann,Magdalini Polymenidou

A conformational switch controlling the toxicity of the prion protein

控制朊病毒蛋白毒性的构象开关

Karl Frontzek #, Marco Bardelli #, Assunta Senatore #, Anna Henzi, Regina R Reimann, Seden Bedir, Marika Marino, Rohanah Hussain, Simon Jurt, Georg Meisl, Mattia Pedotti, Federica Mazzola, Giuliano Siligardi, Oliver Zerbe, Marco Losa, Tuomas Knowles, Asvin Lakkaraju, Caihong Zhu, Petra Schwarz, Simo

Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies

与朊病毒蛋白结合的配体可诱导其蛋白水解释放,具有治疗神经退行性蛋白病的潜力

Luise Linsenmeier, Behnam Mohammadi, Mohsin Shafiq, Karl Frontzek, Julia Bär, Amulya N Shrivastava, Markus Damme, Feizhi Song, Alexander Schwarz, Stefano Da Vela, Tania Massignan, Sebastian Jung, Angela Correia, Matthias Schmitz, Berta Puig, Simone Hornemann, Inga Zerr, Jörg Tatzelt, Emiliano Biasin

Loss of PIKfyve drives the spongiform degeneration in prion diseases

PIKfyve 的缺失导致朊病毒疾病中的海绵状变性

Asvin K K Lakkaraju, Karl Frontzek, Emina Lemes, Uli Herrmann, Marco Losa, Rajlakshmi Marpakwar, Adriano Aguzzi

Protective anti-prion antibodies in human immunoglobulin repertoires

人类免疫球蛋白库中的保护性抗朊病毒抗体

Assunta Senatore, Karl Frontzek #, Marc Emmenegger #, Andra Chincisan, Marco Losa, Regina Reimann, Geraldine Horny, Jingjing Guo, Sylvie Fels, Silvia Sorce, Caihong Zhu, Nathalie George, Stefan Ewert, Thomas Pietzonka, Simone Hornemann, Adriano Aguzzi

SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease

SARM1 缺乏会上调 XAF1,促进神经元凋亡,并加速朊病毒疾病

Caihong Zhu, Bei Li, Karl Frontzek, Yingjun Liu, Adriano Aguzzi

Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish

活性受体酪氨酸激酶(而非 Brachyury)足以引发斑马鱼脊索瘤

Gianluca D'Agati, Elena María Cabello, Karl Frontzek, Elisabeth J Rushing, Robin Klemm, Mark D Robinson, Richard M White, Christian Mosimann, Alexa Burger

Neurotoxic Antibodies against the Prion Protein Do Not Trigger Prion Replication

针对朊病毒蛋白的神经毒性抗体不会引发朊病毒复制

Karl Frontzek, Manuela Pfammatter, Silvia Sorce, Assunta Senatore, Petra Schwarz, Rita Moos, Katrin Frauenknecht, Simone Hornemann, Adriano Aguzzi