日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Collateral-resistance to estrogen and HER-activated growth is associated with modified AKT, ERα, and cell-cycle signaling in a breast cancer model

乳腺癌模型中对雌激素和 HER 激活生长的附带抵抗与 AKT、ERα 和细胞周期信号的改变有关

Kate M Moore #, Vera Cerqueira #, Kenneth G MacLeod #, Peter Mullen, Richard L Hayward, Simon Green, David J Harrison, David A Cameron, Simon P Langdon

A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability

抑制SRC的构象选择性模式可提高药物疗效和耐受性

Carolin Temps, Daniel Lietha, Emily R Webb #, Xue-Feng Li #, John C Dawson #, Morwenna Muir, Kenneth G Macleod, Teresa Valero, Alison F Munro, Rafael Contreras-Montoya, Juan R Luque-Ortega, Craig Fraser, Henry Beetham, Christina Schoenherr, Maria Lopalco, Mark J Arends, Margaret C Frame, Bin-Zhi Qia

Integrative analysis of multi-platform reverse-phase protein array data for the pharmacodynamic assessment of response to targeted therapies

多平台反相蛋白质阵列数据的整合分析用于靶向治疗药效学评估

Adam Byron, Stephan Bernhardt, Bérèngere Ouine, Aurélie Cartier, Kenneth G Macleod, Neil O Carragher, Vonick Sibut, Ulrike Korf, Bryan Serrels, Leanne de Koning0

Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging

通过靶向 NFκB 信号逆转 16p13.11 染色体微重复引起的增殖缺陷:患者来源的神经元前体细胞、脑类器官和体内脑成像的综合研究

Mandy Johnstone, Navneet A Vasistha, Miruna C Barbu, Owen Dando, Karen Burr, Edward Christopher, Sophie Glen, Christelle Robert, Rana Fetit, Kenneth G Macleod, Matthew R Livesey, David St Clair, Douglas H R Blackwood, Kirsty Millar, Neil O Carragher, Giles E Hardingham, David J A Wyllie, Eve C Johns

Mer-mediated eosinophil efferocytosis regulates resolution of allergic airway inflammation

Mer介导的嗜酸性粒细胞吞噬作用调节过敏性气道炎症的消退

Jennifer M Felton ,Christopher D Lucas ,David A Dorward ,Rodger Duffin ,Tiina Kipari ,Sonja Vermeren ,Calum T Robb ,Kenneth G MacLeod ,Bryan Serrels ,Jürgen Schwarze ,Christopher Haslett ,Ian Dransfield ,Adriano G Rossi

Global histone modification fingerprinting in human cells using epigenetic reverse phase protein array

使用表观遗传反相蛋白阵列对人类细胞进行整体组蛋白修饰指纹识别

Marina Partolina, Hazel C Thoms, Kenneth G MacLeod, Giovanny Rodriguez-Blanco, Matthew N Clarke, Anuroop V Venkatasubramani, Rima Beesoo, Vladimir Larionov, Vidushi S Neergheen-Bhujun, Bryan Serrels, Hiroshi Kimura, Neil O Carragher, Alexander Kagansky

Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach

细胞外钯催化 5-氟-1-炔丙基尿嘧啶脱烷基化作为生物正交活化前体药物的方法

Jason T Weiss, John C Dawson, Kenneth G Macleod, Witold Rybski, Craig Fraser, Carmen Torres-Sánchez, E Elizabeth Patton, Mark Bradley, Neil O Carragher, Asier Unciti-Broceta