日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting a lineage-specific PI3Kɣ-Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule

使用异双功能降解分子靶向急性髓系白血病中的谱系特异性 PI3Kɣ-Akt 信号传导模块

Lois M Kelly #, Justine C Rutter #, Kevin H Lin #, Frank Ling, Matthieu Duchmann, Emmanuelle Latour, Nadia Arang, Hélène Pasquer, Duong Ho Nhat, Juliette Charles, Shane T Killarney, Hazel X Ang, Federica Namor, Cécile Culeux, Bérangère Lombard, Damarys Loew, Danielle L Swaney, Nevan J Krogan, Luc Br

PitViper: a software for comparative meta-analysis and annotation of functional screening data

PitViper:一款用于功能筛查数据的比较荟萃分析和注释的软件

Paul-Arthur Meslin, Lois M Kelly, Salima Benbarche, Séverine Lecourt, Kevin H Lin, Justine C Rutter, Christopher F Bassil, Raphael Itzykson, Kris C Wood, Alexandre Puissant, Camille Lobry

Executioner caspases restrict mitochondrial RNA-driven Type I IFN induction during chemotherapy-induced apoptosis

执行者胱天蛋白酶在化疗诱导的细胞凋亡过程中限制线粒体 RNA 驱动的 I 型干扰素诱导

Shane T Killarney, Rachel Washart, Ryan S Soderquist, Jacob P Hoj, Jamie Lebhar, Kevin H Lin, Kris C Wood

P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia

P2RY2-AKT 激活是 XPO1 抑制在急性髓系白血病中可治疗的结果

Kevin H Lin #, Justine C Rutter #, Abigail Xie, Shane T Killarney, Camille Vaganay, Chaima Benaksas, Frank Ling, Gaetano Sodaro, Paul-Arthur Meslin, Christopher F Bassil, Nina Fenouille, Jacob Hoj, Rachel Washart, Hazel X Ang, Christian Cerda-Smith, Paul Chaintreuil, Arnaud Jacquel, Patrick Auberger

ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells

ABL 变构抑制剂与他汀类药物协同作用增强转移性肺癌细胞凋亡

Jillian Hattaway Luttman, Jacob P Hoj, Kevin H Lin, Jiaxing Lin, Jing Jin Gu, Clay Rouse, Amanda G Nichols, Nancie J MacIver, Kris C Wood, Ann Marie Pendergast

Ten-year Thyroid Cancer Incidence in an Integrated Healthcare Delivery System

综合医疗保健服务体系中甲状腺癌的十年发病率

Kim, Stephanie J; Durr, Megan L; Darbinian, Jeanne A; Sakoda, Lori C; Meltzer, Charles J; Arzumanyan, Hasmik; Wang, Kevin H; Lin, Jonathan K; Gurushanthaiah, Deepak; Lo, Joan C

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer

利用拮抗性多效性设计化疗诱导的进化陷阱,以靶向癌症耐药性。

Kevin H Lin # ,Justine C Rutter # ,Abigail Xie ,Bryann Pardieu ,Emily T Winn ,Reinaldo Dal Bello ,Antoine Forget ,Raphael Itzykson ,Yeong-Ran Ahn ,Ziwei Dai ,Raiyan T Sobhan ,Gray R Anderson ,Katherine R Singleton ,Amy E Decker ,Peter S Winter ,Jason W Locasale ,Lorin Crawford ,Alexandre Puissant ,Kris C Wood

The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies

叶酸循环酶 MTHFR 是细胞对 MYC 靶向疗法反应的关键调节剂

Angela Su #, Frank Ling #, Camille Vaganay, Gaetano Sodaro, Chaïma Benaksas, Reinaldo Dal Bello, Antoine Forget, Bryann Pardieu, Kevin H Lin, Justine C Rutter, Christopher F Bassil, Gael Fortin, Justine Pasanisi, Iléana Antony-Debré, Gabriela Alexe, Jean-François Benoist, Alain Pruvost, Yana Pikman,

Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers

低剂量垂直抑制 RAF-MEK-ERK 级联可导致 KRAS 突变癌细胞凋亡

Irem Ozkan-Dagliyan, J Nathaniel Diehl, Samuel D George, Antje Schaefer, Bjoern Papke, Kathleen Klotz-Noack, Andrew M Waters, Craig M Goodwin, Prson Gautam, Mariaelena Pierobon, Sen Peng, Thomas S K Gilbert, Kevin H Lin, Onur Dagliyan, Krister Wennerberg, Emanuel F Petricoin 3rd, Nhan L Tran, Shripa

Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity

对 AML 中代谢-凋亡界面的系统解剖表明血红素生物合成是药物敏感性的调节剂

Kevin H Lin, Abigail Xie, Justine C Rutter, Yeong-Ran Ahn, Julia M Lloyd-Cowden, Amanda G Nichols, Ryan S Soderquist, Timothy R Koves, Deborah M Muoio, Nancie J MacIver, Jatinder K Lamba, Timothy S Pardee, Chad M McCall, David A Rizzieri, Kris C Wood