New pyrazole-pyridazine hybrids as selective COX-2 inhibitors: design, synthesis, molecular docking, in silico studies and investigation of their anti-inflammatory potential by evaluation of TNF-α, IL-6, PGE-2 and NO in LPS-induced RAW264.7 macrophages.

新型吡唑-哒嗪杂合物作为选择性 COX-2 抑制剂：设计、合成、分子对接、计算机模拟研究，并通过评估 LPS 诱导的 RAW264.7 巨噬细胞中 TNF-α、IL-6、PGE-2 和 NO 来研究其抗炎潜力