日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Single-dose replicon RNA Sudan virus vaccine uniformly protects female guinea pigs from disease.

单剂量复制子RNA苏丹病毒疫苗可均匀保护雌性豚鼠免受疾病侵害

O'Donnell Kyle L, Anhalt Hanna, Saturday Greg, Warner Nikole L, Hinkley Troy, Stone E Taylor, Hatzakis Kiara, Khandhar Amit P, Banadyga Logan, Erasmus Jesse H, Marzi Andrea

Preclinical development of lyophilized self-replicating RNA vaccines for COVID-19 and malaria with improved long-term thermostability.

具有改进的长期热稳定性的冻干自复制RNA疫苗用于COVID-19和疟疾的临床前开发

Gulati Gaurav K, Simpson Adrian C, MacMillen Zachary, Krieger Kyle, Sharma Shibbu, Erasmus Jesse H, Reed Steven G, Davie James W, Avril Marion, Khandhar Amit P

A replicating RNA vaccine confers protection against Crimean-Congo hemorrhagic fever in cynomolgus macaques.

复制型RNA疫苗可保护食蟹猴免受克里米亚-刚果出血热的侵害

Hawman David W, Leventhal Shanna, Meade-White Kimberly, Graham William, Gaffney Karen, Khandhar Amit, Murray Justin, Prado-Smith Jessy, Shaia Carl, Saturday Greg, Buda Henry, Moise Lenny, Erasmus Jesse, Feldmann Heinz

A self-amplifying RNA vaccine prevents enterovirus D68 infection and disease in preclinical models

一种自扩增RNA疫苗在临床前模型中可预防肠道病毒D68感染和疾病。

Warner, Nikole L; Archer, Jacob; Park, Stephanie; Singh, Garima; McFadden, Kathryn M; Kimura, Taishi; Nicholes, Katrina; Simpson, Adrian; Kaelber, Jason T; Hawman, David W; Feldmann, Heinz; Khandhar, Amit P; Berglund, Peter; Vogt, Matthew R; Erasmus, Jesse H

A replicating RNA vaccine confers protection in a rhesus macaque model of Crimean-Congo hemorrhagic fever

一种复制型RNA疫苗在恒河猴克里米亚-刚果出血热模型中提供了保护作用。

Hawman, David W; Leventhal, Shanna S; Meade-White, Kimberly; Khandhar, Amit; Murray, Justin; Lovaglio, Jamie; Shaia, Carl; Saturday, Greg; Hinkley, Troy; Erasmus, Jesse; Feldmann, Heinz

A polyvalent RNA vaccine reduces the immune imprinting phenotype in mice and induces neutralizing antibodies against omicron SARS-CoV-2

一种多价RNA疫苗可降低小鼠的免疫印迹表型,并诱导产生针对SARS-CoV-2 omicron的中和抗体。

Costa Rocha, Vinicius Pinto; Souza Machado, Bruna Aparecida; Barreto, Breno Cardim; Quadros, Helenita Costa; Santana Fernandes, Antonio Márcio; Lima, Eduarda Dos Santos; Bandeira, Mariana Evangelista; Meira, Cássio Santana; Moraes Dos Santos Fonseca, Larissa; Erasmus, Jesse; Khandhar, Amit; Berglund, Peter; Reed, Steve; José da Silva Badaró, Roberto; Pereira Soares, Milena Botelho

A replicon RNA vaccine can induce durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned

即使中和抗体减弱,复制子RNA疫苗仍可在非人灵长类动物体内诱导针对SARS-CoV-2的持久保护性免疫。

O'Connor, Megan A; Hawman, David W; Meade-White, Kimberly; Leventhal, Shanna; Song, Wenjun; Randall, Samantha; Archer, Jacob; Lewis, Thomas B; Brown, Brieann; Fredericks, Megan N; Sprouse, Kaitlin R; Tunggal, Hillary C; Maughan, Mara; Iwayama, Naoto; Ahrens, Chul; Garrison, William; Wangari, Solomon; Guerriero, Kathryn A; Hanley, Patrick; Lovaglio, Jamie; Saturday, Greg; Veesler, David; Edlefsen, Paul T; Khandhar, Amit P; Feldmann, Heinz; Fuller, Deborah Heydenburg; Erasmus, Jesse H

Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates

单剂量复制型RNA疫苗可在非人灵长类动物体内诱导产生针对SARS-CoV-2的中和抗体

Erasmus, Jesse H; Khandhar, Amit P; Walls, Alexandra C; Hemann, Emily A; O'Connor, Megan A; Murapa, Patience; Archer, Jacob; Leventhal, Shanna; Fuller, Jim; Lewis, Thomas; Draves, Kevin E; Randall, Samantha; Guerriero, Kathryn A; Duthie, Malcolm S; Carter, Darrick; Reed, Steven G; Hawman, David W; Feldmann, Heinz; Gale, Michael; Veesler, David; Berglund, Peter; Fuller, Deborah Heydenburg

A Nanostructured Lipid Carrier for Delivery of a Replicating Viral RNA Provides Single, Low-Dose Protection against Zika

一种用于递送复制型病毒RNA的纳米结构脂质载体可提供针对寨卡病毒的单次低剂量保护。

Erasmus, Jesse H; Khandhar, Amit P; Guderian, Jeff; Granger, Brian; Archer, Jacob; Archer, Michelle; Gage, Emily; Fuerte-Stone, Jasmine; Larson, Elise; Lin, Susan; Kramer, Ryan; Coler, Rhea N; Fox, Christopher B; Stinchcomb, Dan T; Reed, Steven G; Van Hoeven, Neal

Magnetic Particle Imaging for Highly Sensitive, Quantitative, and Safe in Vivo Gut Bleed Detection in a Murine Model

利用磁粒子成像技术在小鼠模型中实现高灵敏度、定量和安全的体内肠道出血检测

Yu, Elaine Y; Chandrasekharan, Prashant; Berzon, Ran; Tay, Zhi Wei; Zhou, Xinyi Y; Khandhar, Amit P; Ferguson, R Matthew; Kemp, Scott J; Zheng, Bo; Goodwill, Patrick W; Wendland, Michael F; Krishnan, Kannan M; Behr, Spencer; Carter, Jonathan; Conolly, Steven M