日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Recapitulation of plaque formation, tau pathology, and neurodegeneration in a human 3D matrix model of Alzheimer's disease

在阿尔茨海默病的人类三维基质模型中重现斑块形成、tau蛋白病理和神经退行性变

Hebisch, Matthias; Kamin, Viola; Cenini, Giovanna; Piazzesi, Antonia; Bertan, Fabio; Weykopf, Beatrice; Schlee, Julia; Kaniyappan, Senthilvelrajan; Washicosky, Kevin J; Kim, Doo Yeon; Bano, Daniele; Peitz, Michael; Brüstle, Oliver

Recapitulating Alzheimer's disease pathophysiology with a microfluidic neurospheroid-grafted endothelial barrier model

利用微流控神经球体移植内皮屏障模型重现阿尔茨海默病病理生理过程

Uzoechi, Samuel Chidiebere; Johnson-Campbell, Charity; Badeaux, Cody Joseph; Kwak, Sang Su; Kim, Doo Yeon; Yun, Yeoheung

Innate Immune Evasion of Lyme Disease Pathogen Drives Alzheimer-Like Pathology.

莱姆病病原体的先天免疫逃逸驱动类似阿尔茨海默病的病理变化。

Haapasalo Karita, Heiland Lilith, Kumar Deepak Kumar Vijaya, Uvarov Pavel, Moir Alexander, Maaser-Hecker Anna, Wang Xun, Juselius Eeva, Syed Shahan, Tuhkala Antti, Kajander Tommi, Lappalainen Maija, Hytönen Jukka, Varjosalo Markku, Kim Doo Yeon, Kamm Roger, Meri Taru, Choi Se Hoon, Tanzi Rudolph

Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer's disease.

兴奋性和抑制性神经元对阿尔茨海默病的分子适应性特征。

Castanho Isabel, Naderi Yeganeh Pourya, Boix Carles A, Morgan Sarah L, Mathys Hansruedi, Prokopenko Dmitry, White Bartholomew, Soto Larisa M, Pegoraro Giulia, Shah Saloni, Ploumakis Athanasios, Kalavros Nikolas, Bennett David A, Lange Christoph, Kim Doo Yeon, Bertram Lars, Tsai Li-Huei, Kellis Manolis, Tanzi Rudolph E, Hide Winston

Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer's disease.

对人类和 3D 细胞模型进行整合通路分析,确定 p38 MAPK-MK2 轴是阿尔茨海默病的一种治疗靶点

Naderi Yeganeh Pourya, Kwak Sang Su, Jorfi Mehdi, Koler Katjuša, Kalatturu Thejesh, von Maydell Djuna, Liu Zhiqing, Guo Kevin, Choi Younjung, Park Joseph, Abarca Nelson, Bakiasi Grisilda, Cetinbas Murat, Sadreyev Ruslan, Griciuc Ana, Quinti Luisa, Choi Se Hoon, Xia Weiming, Tanzi Rudolph E, Hide Winston, Kim Doo Yeon

Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer's disease

对细胞间通讯的系统分析揭示了SEMA6D-TREM2在阿尔茨海默病中调节小胶质细胞功能的作用

D'Oliveira Albanus, Ricardo; Finan, Gina M; Brase, Logan; Sweeney, Nicholas; Kim, Tae Yeon; Chen, Shuo; Ryoo, Yeonsu; Park, Joseph; Guo, Qi; Iyer, Abhirami K; Acquarone, Mariana; You, Shih-Feng; Novotny, Brenna C; Mace, Emily M; Ribeiro Pereira, Patricia M; Morris, John C; Holtzman, David M; McDade, Eric; Farlow, Martin; Chhatwal, Jasmeer P; Benitez, Bruno A; Piccio, Laura; Perrin, Richard J; Sutherland, Greg T; Ma, Qin; Karch, Celeste M; Kim, Doo Yeon; Tanzi, Rudolph E; Fu, Hongjun; Harari, Oscar; Kim, Tae-Wan

Cryopreserving 3D cell culture models of Alzheimer's disease in hydrogel microbeads.

将阿尔茨海默病的三维细胞培养模型冷冻保存于水凝胶微珠中

Kim Jae Jung, Hebisch Matthias, Kwak Sang Su, Zheng Monica, Nuli Shreya, Bae Jun-Seok, Brand Emma, Tanzi Rudolph E, Irimia Daniel, Kim Doo Yeon

A framework for translating tauopathy therapeutics: Drug discovery to clinical trials

tau蛋白病治疗转化框架:从药物发现到临床试验

Feldman, Howard H; Cummings, Jeffrey L; Boxer, Adam L; Staffaroni, Adam M; Knopman, David S; Sukoff Rizzo, Stacey J; Territo, Paul R; Arnold, Steven E; Ballard, Clive; Beher, Dirk; Boeve, Bradley F; Dacks, Penny A; Diaz, Kristophe; Ewen, Colin; Fiske, Brian; Gonzalez, M Isabel; Harris, Glenn A; Hoffman, Beth J; Martinez, Terina N; McDade, Eric; Nisenbaum, Laura K; Palma, Jose-Alberto; Quintana, Melanie; Rabinovici, Gil D; Rohrer, Jonathan D; Rosen, Howard J; Troyer, Matthew D; Kim, Doo Yeon; Tanzi, Rudolph E; Zetterberg, Henrik; Ziogas, Nick K; May, Patrick C; Rommel, Amy

The Impact of the Cellular Environment and Aging on Modeling Alzheimer's Disease in 3D Cell Culture Models

细胞环境和衰老对三维细胞培养模型中阿尔茨海默病建模的影响

Hebisch, Matthias; Klostermeier, Stefanie; Wolf, Katharina; Boccaccini, Aldo R; Wolf, Stephan E; Tanzi, Rudolph E; Kim, Doo Yeon

Evaluation of bumetanide as a potential therapeutic agent for Alzheimer's disease

评估布美他尼作为阿尔茨海默病潜在治疗药物的疗效

Boyarko, Ben; Podvin, Sonia; Greenberg, Barry; Momper, Jeremiah D; Huang, Yadong; Gerwick, William H; Bang, Anne G; Quinti, Luisa; Griciuc, Ana; Kim, Doo Yeon; Tanzi, Rudolph E; Feldman, Howard H; Hook, Vivian