日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

GenomePAM directs PAM characterization and engineering of CRISPR-Cas nucleases using mammalian genome repeats

GenomePAM指导利用哺乳动物基因组重复序列对CRISPR-Cas核酸酶进行PAM表征和工程改造。

Yu, Miao; Ai, Limei; Wang, Bang; Lian, Shifeng; Ip, Lawrence; Liu, James; Li, Linxian; Tsai, Shengdar Q; Kleinstiver, Benjamin P; Zheng, Zongli

Nucleotide-resolution mapping of regulatory elements via allelic readout of tiled base editing.

通过等位基因读取平铺碱基编辑,实现调控元件的核苷酸分辨率定位。

Becerra Basheer, Wittibschlager Sandra, Patel Zain M, Kutschat Ana P, Delano Justin, Che Eric, Tauber Anzhelika, Wu Ting, Starrs Marlena, Horstmann Christina S, Müller Sophie, Whittaker Madelynn N, Sylvander Elise, Lehner Manfred, Love Michael I, Kleinstiver Benjamin P, Jankowiak Martin, Bauer Daniel E, Seruggia Davide, Pinello Luca

Statins and genetic inhibition of the mevalonate pathway activate an ATF3-STMN2 regenerative program

他汀类药物和甲羟戊酸途径的基因抑制可激活ATF3-STMN2再生程序

Nolan, Matthew; Aryal, Sandeep; Ndayambaje, I Sandra; Cao, Maize; Lee, Peyton; Hovde, Moriah; Yun, Shuqi; Wlaschin, Josette; Held, Aaron; Beaussant, Hortense; Wymann, Benjamin; Zong-Lee, Chao; Lim, Su Min; Jiang, Xin; Ramesh, Nandini; Agra Almeida Quadros, Ana Rita; Boulos, Ayub; Zinter, Nicolas; Salem, Shireen; El-Tayar, Laïla; Beccari, Melinda; Presa, Maximiliano; Jourdan Ferreras Reyes, Charles; Ruan, Yin Yin; Griesman, Grant; Aguilar, Corey; Hawrot, James; Wheeler, Hayden; Melamed, Zevik; Kleinstiver, Benjamin P; Albers, Mark; Cleveland, Don W; Tanzi, Rudolph E; Lutz, Cathleen M; Hubbard, Robert D; Kobayashi, Dione; Ward, Michael; R R Alves, Christiano; Wainger, Brian; Pichon, Claire Le; Lagier-Tourenne, Clotilde

Mechanistic machine learning enables interpretable and generalizable prediction of prime editing outcomes

机制机器学习能够对主要编辑结果进行可解释且可推广的预测。

Hsu, Alvin; Chen, Peter J; Li, Angus H; Hemez, Colin F; Gao, Xin D; Terrey, Markus; Nelson, Charlie; Selvam, Vijay; Cristian, Ana; McElroy, Amber N; Steinbeck, Benjamin J; Mahadeshwar, Gandhar K; Pandey, Smriti; Barsdale, Zachary; Chen, Paul Z; Sousa, Alexander A; Sakai, Holt A; Silverstein, Rachel A; Morad, Ilias; Krueger, Ryan K; Shen, Max W; Kleinstiver, Benjamin P; Lutz, Cathleen M; Tolar, Jakub; Blazar, Bruce R; Osborn, Mark J; Liu, David R

Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease

利用患者特异性体内基因编辑技术治疗罕见遗传疾病

Musunuru, Kiran; Grandinette, Sarah A; Wang, Xiao; Hudson, Taylor R; Briseno, Kevin; Berry, Anne Marie; Hacker, Julia L; Hsu, Alvin; Silverstein, Rachel A; Hille, Logan T; Ogul, Aysel N; Robinson-Garvin, Nancy A; Small, Juliana C; McCague, Sarah; Burke, Samantha M; Wright, Christina M; Bick, Sarah; Indurthi, Venkata; Sharma, Shweta; Jepperson, Michael; Vakulskas, Christopher A; Collingwood, Michael; Keogh, Katie; Jacobi, Ashley; Sturgeon, Morgan; Brommel, Christian; Schmaljohn, Ellen; Kurgan, Gavin; Osborne, Thomas; Zhang, He; Kinney, Kyle; Rettig, Garrett; Barbosa, Christopher J; Semple, Sean C; Tam, Ying K; Lutz, Cathleen; George, Lindsey A; Kleinstiver, Benjamin P; Liu, David R; Ng, Kim; Kassim, Sadik H; Giannikopoulos, Petros; Alameh, Mohamad-Gabriel; Urnov, Fyodor D; Ahrens-Nicklas, Rebecca C

Custom CRISPR-Cas9 PAM variants via scalable engineering and machine learning

通过可扩展的工程和机器学习技术构建定制的 CRISPR-Cas9 PAM 变体

Silverstein, Rachel A; Kim, Nahye; Kroell, Ann-Sophie; Walton, Russell T; Delano, Justin; Butcher, Rossano M; Pacesa, Martin; Smith, Blaire K; Christie, Kathleen A; Ha, Leillani L; Meis, Ronald J; Clark, Aaron B; Spinner, Aviv D; Lazzarotto, Cicera R; Li, Yichao; Matsubara, Azusa; Urbina, Elizabeth O; Dahl, Gary A; Correia, Bruno E; Marks, Debora S; Tsai, Shengdar Q; Pinello, Luca; De Ravin, Suk See; Liu, Qin; Kleinstiver, Benjamin P

Treatment of a severe vascular disease using a bespoke CRISPR-Cas9 base editor in mice.

利用定制的 CRISPR-Cas9 碱基编辑器治疗小鼠的严重血管疾病。

Alves Christiano R R, Das Sabyasachi, Krishnan Vijai, Ha Leillani L, Fox Lauren R, Stutzman Hannah E, Shamber Claire E, Kalailingam Pazhanichamy, McCarthy Siobhan, Lino Cardenas Christian L, Fong Claire E, Imai Takahiko, Mitra Sunayana, Yun Shuqi, Wood Rachael K, Benning Friederike M C, Roh Kangsan, Lawton Joseph, Kim Nahye, Silverstein Rachel A, Ferreira da Silva Joana, de la Cruz Demitri, Richa Rashmi, Xie Jun, Gray-Edwards Heather L, Malhotra Rajeev, Chung David Y, Chao Luke H, Tsai Shengdar Q, Maguire Casey A, Lindsay Mark E, Kleinstiver Benjamin P, Musolino Patricia L

Engineering of CD63 Enables Selective Extracellular Vesicle Cargo Loading and Enhanced Payload Delivery.

CD63 的工程改造可实现选择性细胞外囊泡货物装载和增强有效载荷递送

Obuchi Wataru, Zargani-Piccardi Ayrton, Leandro Kevin, Rufino-Ramos David, Di Lanni Emilio, Frederick Dawn Madison, Maalouf Katia, Nieland Lisa, Xiao Tianhe, Repiton Pierre, Vaine Christine A, Kleinstiver Benjamin P, Bragg D Cristopher, Lee Hakho, Miller Miles A, Breakefield Xandra O, Breyne Koen

An opportune time for targeted brain arteriovenous malformation therapy

针对脑动静脉畸形进行靶向治疗的良机

Hale, Andrew T; Kalailingam, Pazhanichamy; Kundishora, Adam J; Reeves, Benjamin C; Brastianos, Priscilla K; Shih, Helen A; Jain, Rakesh K; Ning, MingMing; Stapleton, Christopher J; Patel, Aman B; Smith, Edward R; Chapman, Paul H; Rabinov, James D; Kleinstiver, Benjamin P; Musolino, Patricia L; Kahle, Kristopher T

Environmental impact, cost, and acceptability of a laboratory sustainability certification program for biomedical research in an academic medical center

学术医疗中心生物医学研究实验室可持续性认证项目的环境影响、成本和可接受性分析

Padget, Michael; Sörme, Pernilla; Spezia, Michael; Slaugenhaupt, Susan A; McKowen, James; Kirchner, Emily; Ameral, Natalie; Reis, Surya A; Slater, Damien; Haggarty, Stephen J; Kleinstiver, Benjamin P; Dunn, Erin C; Larocque, Regina; Alves, Christiano R R; Stern, Max; Pelli, Alida; Duhaime, Ann-Christine