日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combined Flt3L and CD40 agonism restores dendritic cell-driven T cell immunity in pancreatic cancer

Flt3L 和 CD40 联合激动剂可恢复胰腺癌中树突状细胞驱动的 T 细胞免疫。

Hogg, Graham D; Weinstein, Alyssa G; Kingston, Natalie L; Liu, Xiuting; Dres, Olivia M; Kang, Liang-I; Lander, Varintra E; Kao, Yu-Lan; Ahmad, Faiz; Knolhoff, Brett L; Shenoy, Varun V; Sells, Blake; Jayasinghe, Reyka G; Houston, Andrew; Liu, Tiantian; Herndon, John M; Murphy, Kenneth M; Ding, Li; Fields, Ryan C; Panni, Roheena Z; Hawkins, William G; DeNardo, David G

Targeting tumor-intrinsic TAK1 triggers anti-tumor immunity and sensitizes pancreatic cancer to checkpoint blockade

靶向肿瘤内在的TAK1可触发抗肿瘤免疫,并使胰腺癌对免疫检查点阻断疗法更加敏感

Bansod, Sapana P; Chen, Timothy Hung-Po; Somani, Vikas K; Li, Lin; Modekurty, Suneeta; Knolhoff, Brett L; Fields, Ryan C; Ruzinova, Marianna B; DeNardo, David G; Lim, Kian-Huat

Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer

衰老定义了肌成纤维细胞的一个独特亚群,该亚群在胰腺癌中协调免疫抑制

Belle, Jad I; Sen, Devashish; Baer, John M; Liu, Xiuting; Lander, Varintra E; Ye, Jiayu; Sells, Blake E; Knolhoff, Brett L; Faiz, Ahmad; Kang, Liang-I; Qian, Guhan; Fields, Ryan C; Ding, Li; Kim, Hyun; Provenzano, Paolo P; Stewart, Sheila A; DeNardo, David G

Stromal reprogramming overcomes resistance to RAS-MAPK inhibition to improve pancreas cancer responses to cytotoxic and immune therapy

基质重编程克服了对RAS-MAPK抑制剂的耐药性,从而改善了胰腺癌对细胞毒性药物和免疫疗法的反应。

Liu, Xiuting; Baer, John M; Stone, Meredith L; Knolhoff, Brett L; Hogg, Graham D; Turner, Madeleine C; Kao, Yu-Lan; Weinstein, Alyssa G; Ahmad, Faiz; Chen, Jie; Schmidt, Andrew D; Klomp, Jeffrey A; Coho, Heather; Coho, Kayjana S; Coma, Silvia; Pachter, Jonathan A; Bryant, Kirsten L; Kang, Liang-I; Lim, Kian-Huat; Beatty, Gregory L; DeNardo, David G

Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity

CD11b激动剂通过激活STING-干扰素信号通路,在特定环境下增强抗肿瘤免疫力。

Xiuting Liu ,Graham D Hogg ,Chong Zuo ,Nicholas C Borcherding ,John M Baer ,Varintra E Lander ,Liang-I Kang ,Brett L Knolhoff ,Faiz Ahmad ,Robin E Osterhout ,Anna V Galkin ,Jean-Marie Bruey ,Laura L Carter ,Cedric Mpoy ,Kiran R Vij ,Ryan C Fields ,Julie K Schwarz ,Haeseong Park ,Vineet Gupta ,David G DeNardo

Fibrosis induced by resident macrophages has divergent roles in pancreas inflammatory injury and PDAC

由驻留巨噬细胞诱导的纤维化在胰腺炎症损伤和胰腺导管腺癌(PDAC)中发挥着不同的作用。

John M Baer,Chong Zuo,Liang-I Kang,Angela Alarcon de la Lastra,Nicholas C Borcherding,Brett L Knolhoff,Savannah J Bogner,Yu Zhu,Liping Yang,Jennifer Laurent,Mark A Lewis,Nan Zhang,Ki-Wook Kim,Ryan C Fields,Wayne M Yokoyama,Jason C Mills,Li Ding,Gwendalyn J Randolph,David G DeNardo

Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy

基质和治疗诱导的巨噬细胞增殖促进 PDAC 进展和对先天免疫疗法的敏感性

Chong Zuo, John M Baer, Brett L Knolhoff, Jad I Belle, Xiuting Liu, Angela Alarcon De La Lastra, Christina Fu, Graham D Hogg, Natalie L Kingston, Marcus A Breden, Paarth B Dodhiawala, Daniel Cui Zhou, Varintra E Lander, C Alston James, Li Ding, Kian-Huat Lim, Ryan C Fields, William G Hawkins, Jason

Systemic Alterations in Type-2 Conventional Dendritic Cells Lead to Impaired Tumor Immunity in Pancreatic Cancer

型常规树突状细胞的系统性改变导致胰腺癌的肿瘤免疫力受损

C Alston James, John M Baer, Chong Zou, Usman Y Panni, Brett L Knolhoff, Graham D Hogg, Natalie L Kingston, Liang-I Kang, Varintra E Lander, Jingqin Luo, Yu Tao, Mark A Watson, Rebecca Aft, Ryan C Fields, William G Hawkins, David G DeNardo

Standardizing non-targeted analysis reporting to advance exposure science and environmental epidemiology

规范非靶向分析报告以推进暴露科学和环境流行病学

Phillips, Allison L; Peter, Katherine T; Sobus, Jon R; Fisher, Christine M; Manzano, Carlos A; McEachran, Andrew D; Williams, Antony J; Knolhoff, Ann M; Ulrich, Elin M

Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade

通过FAK抑制进行基质重编程可克服辐射抗性,从而启动免疫反应并对检查点阻断产生反应。

Varintra E Lander ,Jad I Belle ,Natalie L Kingston ,John M Herndon ,Graham D Hogg ,Xiuting Liu ,Liang-I Kang ,Brett L Knolhoff ,Savannah J Bogner ,John M Baer ,Chong Zuo ,Nicholas C Borcherding ,Daniel P Lander ,Cedric Mpoy ,Jalen Scott ,Michael Zahner ,Buck E Rogers ,Julie K Schwarz ,Hyun Kim # ,David G DeNardo #