日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Pyrimidoindolones as Novel Family VIII Bromodomain Binders

发现嘧啶并吲哚酮类化合物作为新型VIII族溴结构域结合剂

Boerth, Jeffrey A; Schimpl, Marianne; Lucas, Simon C C; Zhang, Jingwen; Code, Erin L; Embrey, Kevin J; Rawlins, Philip B; Wang, Haixia; Storer, R Ian; Di Fruscia, Paolo; Nelson, Jennifer E; Milbradt, Alexander G; Börjesson, Ulf; Gohlke, Andrea; Korboukh, Victoria; Gopalsamy, Ariamala

Development of an LC-MS/MS assay to analyze a lipid-conjugated siRNA by solid phase extraction (SPE) in mouse plasma and tissue using a stable isotope labeled internal standard (SILIS)

利用稳定同位素标记内标(SILIS)通过固相萃取(SPE)法开发LC-MS/MS分析小鼠血浆和组织中脂质偶联siRNA的方法

Sanford, Ethan J; Chen, Jianzhong; Tran, Julia; Korboukh, Ilia; Zhang, Guangnong

RNAi mediated silencing of STAT3/PD-L1 in tumor-associated immune cells induces robust anti-tumor effects in immunotherapy resistant tumors.

RNAi介导的肿瘤相关免疫细胞中STAT3/PD-L1的沉默可对免疫疗法耐药肿瘤产生强大的抗肿瘤作用

Ganesh Shanthi, Kim Min Ju, Lee Jenny, Feng Xudong, Ule Krisjanis, Mahan Amy, Krishnan Harini Sivagurunatha, Wang Zhe, Anzahaee Maryam Yahyaee, Singhal Garima, Korboukh Ilia, Lockridge Jennifer A, Sanftner Laura, Rijnbrand Rene, Abrams Marc, Brown Bob D

Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells

失活的 USP14 和失活的 UCHL5 导致哺乳动物细胞中不同泛素化蛋白质的积累

Jayashree Chadchankar, Victoria Korboukh, Leslie C Conway, Heike J Wobst, Chandler A Walker, Peter Doig, Steve J Jacobsen, Nicholas J Brandon, Stephen J Moss, Qi Wang

St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling

圣约翰草通过抑制炎症信号传导减轻小鼠结直肠癌的发生

Manna, Soumen K; Golla, Srujana; Golla, Jaya Prakash; Tanaka, Naoki; Cai, Yan; Takahashi, Shogo; Krausz, Kristopher W; Matsubara, Tsutomu; Korboukh, Ilia; Gonzalez, Frank J

Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8

发现赖氨酸甲基转移酶 SETD8 的选择性底物竞争性抑制剂

Anqi Ma, Wenyu Yu, Fengling Li, Rachel M Bleich, J Martin Herold, Kyle V Butler, Jacqueline L Norris, Victoria Korboukh, Ashutosh Tripathy, William P Janzen, Cheryl H Arrowsmith, Stephen V Frye, Masoud Vedadi, Peter J Brown, Jian Jin

Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain

发现 L3MBTL3 甲基赖氨酸读取域的化学探针

Lindsey I James, Dalia Barsyte-Lovejoy, Nan Zhong, Liubov Krichevsky, Victoria K Korboukh, J Martin Herold, Christopher J MacNevin, Jacqueline L Norris, Cari A Sagum, Wolfram Tempel, Edyta Marcon, Hongbo Guo, Cen Gao, Xi-Ping Huang, Shili Duan, Andrew Emili, Jack F Greenblatt, Dmitri B Kireev, Jian

Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP

发现赖氨酸甲基转移酶 G9a 和 GLP 的体内化学探针

Feng Liu, Dalia Barsyte-Lovejoy, Fengling Li, Yan Xiong, Victoria Korboukh, Xi-Ping Huang, Abdellah Allali-Hassani, William P Janzen, Bryan L Roth, Stephen V Frye, Cheryl H Arrowsmith, Peter J Brown, Masoud Vedadi, Jian Jin

Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3

甲基赖氨酸结合蛋白的小分子配体:L3MBTL3选择性的优化

James, Lindsey I; Korboukh, Victoria K; Krichevsky, Liubov; Baughman, Brandi M; Herold, J Martin; Norris, Jacqueline L; Jin, Jian; Kireev, Dmitri B; Janzen, William P; Arrowsmith, Cheryl H; Frye, Stephen V

Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors

利用 PRMT3 的变构结合位点可产生强效且选择性的抑制剂

Feng Liu, Fengling Li, Anqi Ma, Elena Dobrovetsky, Aiping Dong, Cen Gao, Ilia Korboukh, Jing Liu, David Smil, Peter J Brown, Stephen V Frye, Cheryl H Arrowsmith, Matthieu Schapira, Masoud Vedadi, Jian Jin