Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site
对APC/C泛素变体抑制剂进行蛋白质工程改造,发现了一个隐蔽的K48泛素链结合位点。
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1902889116
Watson, Edmond R; Grace, Christy R R; Zhang, Wei; Miller, Darcie J; Davidson, Iain F; Prabu, J Rajan; Yu, Shanshan; Bolhuis, Derek L; Kulko, Elizaveta T; Vollrath, Ronnald; Haselbach, David; Stark, Holger; Peters, Jan-Michael; Brown, Nicholas G; Sidhu, Sachdev S; Schulman, Brenda A