日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting histone deacetylation, cell cycle regulators and heat shock proteins as novel therapeutic strategies for penile cancers

靶向组蛋白去乙酰化、细胞周期调节因子和热休克蛋白作为阴茎癌的新型治疗策略

Marson, Lara; Skowron, Margaretha A; Pongratanakul, Pailin; Kotthoff, Mara; Poschmann, Gereon; Bohnenberger, Hanibal; Stephan, Alexa; Watolla, Meike M; Mukinovic, Elvira; Stühler, Kai; Kurz, Thomas; Ayoubian, Hiresh; Linxweiler, Johannes; Junker, Kerstin; Nettersheim, Daniel

In vitro characterization of the catalytic domain of human histone deacetylase 5

人组蛋白去乙酰化酶5催化结构域的体外表征

Mammen, Christian; Hornung, Fenja M; Anzenhofer, Christian; Schumacher, Julia; Reiners, Jens; Li, Jingyu; Mazzone, Flaminia; Bilsing, Florestan L; Kassack, Matthias U; Kurz, Thomas; Smits, Sander H J

Integrative preclinical strategy for pharmacokinetic profiling and candidate selection of 3-hydroxypropanamidines: a promising antimalarial class

3-羟基丙脒类药物(一种有前景的抗疟药)的药代动力学分析和候选药物筛选的综合临床前策略

Moritz, Alena; Hirn-Derksen, Bastian; Klein, Saskia; Held, Jana; Wittlin, Sergio; Rottmann, Matthias; Kurz, Thomas; Burckhardt, Bjoern B

VUScope: a mathematical model for evaluating image-based drug response measurements and predicting long-term incubation outcomes

VUScope:一种用于评估基于图像的药物反应测量结果并预测长期潜伏期结果的数学模型

Tran, Nguyen Khoa; Huynh, My Ky; Kotman, Alexander D; Jürgens, Martin; Kurz, Thomas; Dietrich, Sascha; Klau, Gunnar W; Qin, Nan

Small-molecule inhibitor of C‑terminal HSP90 dimerization modulates autophagy and functions synergistically with mTOR inhibition to kill cisplatin-resistant cancer cells.

C端HSP90二聚化的小分子抑制剂可调节自噬,并与mTOR抑制剂协同作用杀死顺铂耐药癌细胞。

David Céline, Sun Yadong, Woloschin Vitalij, Vogt Melina, Dienstbier Niklas, Friedrich Annabelle, Krings Karina S, Schlütermann David, Berning Lena, Lungerich Beate, Akgün Seda, Mendiburo María José, Gertzen Christoph G W, Borkhardt Arndt, Wesselborg Sebastian, Gohlke Holger, Bhatia Sanil, Kurz Thomas, Stork Björn

Structure-Activity Relationships of 3-Hydroxypropanamidines (HPAs) with Potent In Vivo Antimalarial Activity

3-羟基丙脒类化合物(HPAs)的构效关系及其强效的体内抗疟活性

Klein, Saskia; Moritz, Alena; Pessanha de Carvalho, Lais; Knaab, Tanja C; Lungerich, Beate; Meyer, Lukas; Sandström, Jona; Thibaud, Jessica L; de Villiers, Katherine A; Fidock, David A; Wittlin, Sergio; Rottmann, Matthias; Held, Jana; Burckhardt, Bjoern B; Kurz, Thomas

TKK130 is a 3-Hydroxy-Propanamidine (HPA) with Potent Antimalarial In Vivo Activity and a High Barrier to Resistance

TKK130 是一种 3-羟基丙脒 (HPA) 类化合物,具有强效的体内抗疟活性和较高的耐药屏障。

Knaab, Tanja C; Moritz, Alena; Pessanha de Carvalho, Lais; Klein, Saskia; Lungerich, Beate; Lohse, Katharina; Kruse, Linn; Mombo-Ngoma, Ghyslain; Orta, Lily; Thibaud, Jessica L; de Villiers, Katherine A; Fidock, David A; Burckhardt, Bjoern B; Held, Jana; Wittlin, Sergio; Kurz, Thomas

Pharmacological Inhibition of MDM2 Induces Apoptosis in p53-Mutated Triple-Negative Breast Cancer

MDM2的药理学抑制可诱导p53突变型三阴性乳腺癌细胞凋亡

On, Jasmin Linh; Ghaderi, Sahel; Rittmann, Carina; Hoffmann, Greta; Gier, Franziska; Woloschin, Vitalij; Tu, Jia-Wey; Bhatia, Sanil; Kulik, Andrea; Niederacher, Dieter; Neubauer, Hans; Kurz, Thomas; Fehm, Tanja; Esser, Knud

Expanding the Chemical Space of Reverse Fosmidomycin Analogs

拓展反向磷霉素类似物的化学空间

Knak, Talea; Takada, Sana; Illarionov, Boris; Krisilia, Violetta; Pessanha de Carvalho, Lais; Lungerich, Beate; Sakamoto, Yasumitsu; Höfmann, Stefan; Bacher, Adelbert; Kalscheuer, Rainer; Held, Jana; Fischer, Markus; Tanaka, Nobutada; Kurz, Thomas

Flecainide mediated sodium channel blockade enhances blood brain barrier integrity and promotes neuroprotection in neuroinflammation

氟卡尼介导的钠通道阻滞作用可增强血脑屏障完整性,并在神经炎症中发挥神经保护作用。

Sindi, Mustafa; Klees, Diana; Dobelmann, Vera; Disse, Paul; Weigel, Hanne; Lichtenberg, Stefanie; Ricci, Rebekka; Thewes, Leonie; Deniz-Köseoglu, Gülsüm; Hecker, Christina; Müntefering, Thomas; Issberner, Andrea; Gruchot, Joel; Hartung, Hans-Peter; Ruck, Tobias; Berndt, Carsten; Kurz, Thomas; Stark, Holger; Küry, Patrick; Engelhardt, Britta; Lyck, Ruth; Meuth, Sven G; Dietrich, Michael; Albrecht, Philipp