日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling

一项针对122341名欧洲血统患者的主要焦虑症的全基因组关联研究,发现了58个基因位点,并强调了GABA能信号传导的作用。

Strom, Nora I; Verhulst, Brad; Bacanu, Silviu-Alin; Cheesman, Rosa; Purves, Kirstin L; Gedik, Hüseyin; Mitchell, Brittany L; Kwong, Alex S; Faucon, Annika B; Singh, Kritika; Medland, Sarah; Colodro-Conde, Lucia; Krebs, Kristi; Hoffmann, Per; Herms, Stefan; Gehlen, Jan; Ripke, Stephan; Awasthi, Swapnil; Palviainen, Teemu; Tasanko, Elisa M; Peterson, Roseann E; Adkins, Daniel E; Shabalin, Andrey A; Adams, Mark J; Iveson, Matthew H; Campbell, Archie; Thomas, Laurent F; Winsvold, Bendik S; Drange, Ole Kristian; Børte, Sigrid; Ter Kuile, Abigail R; Naamanka, Joonas; Nguyen, Tan-Hoang; Meier, Sandra M; Corfield, Elizabeth C; Hannigan, Laurie; Levey, Daniel F; Czamara, Darina; Weber, Heike; Choi, Karmel W; Pistis, Giorgio; Couvy-Duchesne, Baptiste; Van der Auwera, Sandra; Teumer, Alexander; Karlsson, Robert; Garcia-Argibay, Miguel; Lee, Donghyung; Wang, Rujia; Bjerkeset, Ottar; Stordal, Eystein; Bäckman, Julia; Salum, Giovanni A; Zai, Clement C; Kennedy, James L; Zai, Gwyneth; Tiwari, Arun K; Heilmann-Heimbach, Stefanie; Schmidt, Börge; Kaprio, Jaakko; Kennedy, Martin M; Boden, Joseph; Havdahl, Alexandra; Middeldorp, Christel M; Lopes, Fabiana L; Akula, Nirmala; McMahon, Francis J; Binder, Elisabeth B; Fehm, Lydia; Ströhle, Andreas; Castelao, Enrique; Tiemeier, Henning; Stein, Dan J; Whiteman, David; Olsen, Catherine; Fuller, Zachary; Wang, Xin; Wray, Naomi R; Byrne, Enda M; Lewis, Glyn; Timpson, Nicholas J; Davis, Lea K; Hickie, Ian B; Gillespie, Nathan A; Milani, Lili; Schumacher, Johannes; Woldbye, David P; Forstner, Andreas J; Nöthen, Markus M; Hovatta, Iiris; Horwood, John; Copeland, William E; Maes, Hermine H; McIntosh, Andrew M; Andreassen, Ole A; Zwart, John-Anker; Mors, Ole; Børglum, Anders D; Mortensen, Preben B; Ask, Helga; Reichborn-Kjennerud, Ted; Najman, Jackob M; Stein, Murray B; Gelernter, Joel; Milaneschi, Yuri; Penninx, Brenda W; Boomsma, Dorret I; Maron, Eduard; Erhardt-Lehmann, Angelika; Rück, Christian; Kircher, Tilo T; Melzig, Christiane A; Alpers, Georg W; Arolt, Volker; Domschke, Katharina; Smoller, Jordan W; Preisig, Martin; Martin, Nicholas G; Lupton, Michelle K; Luik, Annemarie I; Reif, Andreas; Grabe, Hans J; Larsson, Henrik; Magnusson, Patrik K; Oldehinkel, Albertine J; Hartman, Catharina A; Breen, Gerome; Docherty, Anna R; Coon, Hilary; Conrad, Rupert; Lehto, Kelli; Deckert, Jürgen; Eley, Thalia C; Mattheisen, Manuel; Hettema, John M

Genome-wide association meta-analyses over one million individuals identify 54 loci associated with urinary incontinence and its subtypes

对超过一百万人的全基因组关联荟萃分析确定了54个与尿失禁及其亚型相关的基因位点。

Moreno, Elisa; Arora, Nikhil; Bertucci-Richter, Emily; Eghtedarian, Reyhane; Andries, Aristomo; Thomas, Laurent F; Horn, Julie; Stafne, Signe N; Pathak, Sweta; FinnGen; Patil, Snehal; Gulla, Dagny; Ollila, Hanna M; Evans, David M; Ippolito, Giulia M; Zhou, Wei; Coward, Eivind; Hveem, Kristian; Surakka, Ida; Moksnes, Marta R; Wolford, Brooke N; Brumpton, Ben M

Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder

全基因组分析确定了30个与强迫症相关的基因位点

Strom, Nora I; Gerring, Zachary F; Galimberti, Marco; Yu, Dongmei; Halvorsen, Matthew W; Abdellaoui, Abdel; Rodriguez-Fontenla, Cristina; Sealock, Julia M; Bigdeli, Tim; Coleman, Jonathan R; Mahjani, Behrang; Thorp, Jackson G; Bey, Katharina; Burton, Christie L; Luykx, Jurjen J; Zai, Gwyneth; Alemany, Silvia; Andre, Christine; Askland, Kathleen D; Bäckman, Julia; Banaj, Nerisa; Barlassina, Cristina; Nissen, Judith Becker; Bienvenu, O Joseph; Black, Donald; Bloch, Michael H; Børte, Sigrid; Bosch, Rosa; Breen, Michael; Brennan, Brian P; Brentani, Helena; Buxbaum, Joseph D; Bybjerg-Grauholm, Jonas; Byrne, Enda M; Cabana-Dominguez, Judit; Camarena, Beatriz; Camarena, Adrian; Cappi, Carolina; Carracedo, Angel; Casas, Miguel; Cavallini, Maria Cristina; Ciullo, Valentina; Cook, Edwin H; Crosby, Jesse; Cullen, Bernadette A; De Schipper, Elles J; Delorme, Richard; Djurovic, Srdjan; Elias, Jason A; Estivill, Xavier; Falkenstein, Martha J; Fundin, Bengt T; Garner, Lauryn; Gironda, Christina; Goes, Fernando S; Grados, Marco A; Grove, Jakob; Guo, Wei; Haavik, Jan; Hagen, Kristen; Harrington, Kelly; Havdahl, Alexandra; Höffler, Kira D; Hounie, Ana G; Hucks, Donald; Hultman, Christina; Janecka, Magdalena; Jenike, Eric; Karlsson, Elinor K; Kelley, Kara; Klawohn, Julia; Krasnow, Janice E; Krebs, Kristi; Lange, Christoph; Lanzagorta, Nuria; Levey, Daniel; Lindblad-Toh, Kerstin; Macciardi, Fabio; Maher, Brion; Mathes, Brittany; McArthur, Evonne; McGregor, Nathaniel; McLaughlin, Nicole C; Meier, Sandra; Miguel, Euripedes C; Mulhern, Maureen; Nestadt, Paul S; Nurmi, Erika L; O'Connell, Kevin S; Osiecki, Lisa; Ousdal, Olga Therese; Palviainen, Teemu; Pedersen, Nancy L; Piras, Fabrizio; Piras, Federica; Potluri, Sriramya; Rabionet, Raquel; Ramirez, Alfredo; Rauch, Scott; Reichenberg, Abraham; Riddle, Mark A; Ripke, Stephan; Rosário, Maria C; Sampaio, Aline S; Schiele, Miriam A; Skogholt, Anne Heidi; Sloofman, Laura G; Smit, Jan; Artigas, María Soler; Thomas, Laurent F; Tifft, Eric; Vallada, Homero; van Kirk, Nathanial; Veenstra-VanderWeele, Jeremy; Vulink, Nienke N; Walker, Christopher P; Wang, Ying; Wendland, Jens R; Winsvold, Bendik S; Yao, Yin; Zhou, Hang; Agrawal, Arpana; Alonso, Pino; Berberich, Götz; Bucholz, Kathleen K; Bulik, Cynthia M; Cath, Danielle; Denys, Damiaan; Eapen, Valsamma; Edenberg, Howard; Falkai, Peter; Fernandez, Thomas V; Fyer, Abby J; Gaziano, J M; Geller, Dan A; Grabe, Hans J; Greenberg, Benjamin D; Hanna, Gregory L; Hickie, Ian B; Hougaard, David M; Kathmann, Norbert; Kennedy, James; Lai, Dongbing; Landén, Mikael; Hellard, Stéphanie Le; Leboyer, Marion; Lochner, Christine; McCracken, James T; Medland, Sarah E; Mortensen, Preben B; Neale, Benjamin M; Nicolini, Humberto; Nordentoft, Merete; Pato, Michele; Pato, Carlos; Pauls, David L; Piacentini, John; Pittenger, Christopher; Posthuma, Danielle; Ramos-Quiroga, Josep Antoni; Rasmussen, Steven A; Richter, Margaret A; Rosenberg, David R; Ruhrmann, Stephan; Samuels, Jack F; Sandin, Sven; Sandor, Paul; Spalletta, Gianfranco; Stein, Dan J; Stewart, S Evelyn; Storch, Eric A; Stranger, Barbara E; Turiel, Maurizio; Werge, Thomas; Andreassen, Ole A; Børglum, Anders D; Walitza, Susanne; Hveem, Kristian; Hansen, Bjarne K; Rück, Christian; Martin, Nicholas G; Milani, Lili; Mors, Ole; Reichborn-Kjennerud, Ted; Ribasés, Marta; Kvale, Gerd; Mataix-Cols, David; Domschke, Katharina; Grünblatt, Edna; Wagner, Michael; Zwart, John-Anker; Breen, Gerome; Nestadt, Gerald; Kaprio, Jaakko; Arnold, Paul D; Grice, Dorothy E; Knowles, James A; Ask, Helga; Verweij, Karin J; Davis, Lea K; Smit, Dirk J; Crowley, James J; Scharf, Jeremiah M; Stein, Murray B; Gelernter, Joel; Mathews, Carol A; Derks, Eske M; Mattheisen, Manuel

Gene-Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies

基因-环境相互作用影响特应性湿疹的风险:人群和体外研究

Standl, Marie; Budu-Aggrey, Ashley; Johnston, Luke J; Elias, Martina S; Arshad, S Hasan; Bager, Peter; Bataille, Veronique; Blakeway, Helena; Bønnelykke, Klaus; Boomsma, Dorret; Brumpton, Ben M; Bustamante Pineda, Mariona; Campbell, Archie; Curtin, John A; Eliasen, Anders; Fadista, João P S; Feenstra, Bjarke; Gerner, Trine; Medina-Gomez, Carolina; Grosche, Sarah; Gutzkow, Kristine B; Halling, Anne-Sofie; Hayward, Caroline; Henderson, John; Herrera-Luis, Esther; Holloway, John W; Hottenga, Joukejan; O'B Hourihane, Jonathan; Hu, Chen; Hveem, Kristian; Irizar, Amaia; Jacquemin, Bénédicte; Jessen, Leon; Kress, Sara; Kurukulaaratchy, Ramesh J; Lau, Susanne; Llop, Sabrina; Løset, Mari; Marenholz, Ingo; Mason, Dan; McCartney, Daniel L; Melbye, Mads; Melén, Erik; Minica, Camelia; Murray, Clare S; Nijsten, Tamar; Pardo, Luba M; Pasmans, Suzanne; Pennell, Craig E; Rinnov, Maria R; Santorelli, Gillian; Schikowski, Tamara; Sheehan, Darina; Simpson, Angela; Söderhäll, Cilla; Thomas, Laurent F; Thyssen, Jacob P; Torrent, Maties; van Beijsterveldt, Toos; Visconti, Alessia; Vonk, Judith M; Wang, Carol A; Xu, Cheng-Jian; Ziyab, Ali H; Custovic, Adnan; Di Meglio, Paola; Duijts, Liesbeth; Flohr, Carsten; Irvine, Alan D; Koppelman, Gerard H; Lee, Young-Ae; Reynolds, Nick J; Smith, Catherine; Langan, Sinéad M; Paternoster, Lavinia; Brown, Sara J

Genetic liability to psoriasis predicts severe disease outcomes

银屑病遗传易感性预示着严重的疾病后果。

Saklatvala, Jake R; Lessard, Samuel; Teder-Laving, Maris; Thomas, Laurent F; Ramessur, Ravi; Zierer, Jonas; Åsvold, Bjørn Olav; Barton, Anne; Baudry, David; Bowes, John; Brumpton, Ben; Bruno, Sandro; Chandran, Vinod; Chatelain, Clément; de Rinaldis, Emanuele; Elder, James T; Ellinghaus, David; Foerster, John; Franke, Andre; Gladman, Dafna D; Gulliver, Wayne; Hüffmeier, Ulrike; Huilaja, Laura; Hveem, Kristian; Khader, Shameer; Kingo, Külli; Klinger, Katherine; Kolbinger, Frank; Kõks, Sulev; Liao, Wilson; Nair, Rajan P; Nititham, Joanne; Rahman, Proton; Reis, André; Sagoo, Manpreet K; Stuart, Philip E; Tasanen, Kaisa; Traks, Tanel; Tsoi, Lam C; Uebe, Steffen; Watts, Katie; Barker, Jonathan N; Mahil, Satveer K; Langan, Sinéad M; Brown, Sara J; Løset, Mari; Paternoster, Lavinia; Dand, Nick; Smith, Catherine H; Simpson, Michael A

The conotoxin Contulakin-G reverses hypersensitivity observed in rodent models of cancer-induced bone pain without inducing tolerance or motor disturbance.

芋螺毒素 Contulakin-G 可逆转啮齿动物癌症诱发骨痛模型中观察到的过敏反应,而不会引起耐受性或运动障碍

Martin Laurent F, Almuslim Moyad, Ismail Khaled A, Ibrahim Mohab M, Moutal Aubin, Cheng Kevin, Stratton Harrison J, Price Theodore J, Vanderah Todd W, Olivera Baldomero M, Khanna Rajesh, Patwardhan Amol

Purine but Not Pyrimidine De Novo Nucleotide Biosynthesis Inhibitors Strongly Enhance the Antiviral Effect of Corresponding Nucleobases Against Dengue Virus

嘌呤而非嘧啶的核苷酸从头生物合成抑制剂可显著增强相应核碱基对登革热病毒的抗病毒作用

Laurent F Bonnac, Christine D Dreis, Madhu Rai, Robert J Geraghty

Cone snail venom-inspired somatostatin receptor 4 (SSTR(4)) agonists as new drug leads for peripheral pain

锥螺毒液启发的生长抑素受体4 (SSTR(4))激动剂作为治疗外周疼痛的新药先导化合物

Bjørn-Yoshimoto, Walden E; Ramiro, Iris Bea L; Koch, Thomas Lund; Engholm, Ebbe; Yeung, Ho Yan; Sørensen, Kasper K; Goddard, Carolyn M; Jensen, Kathrine L; Smith, Nicholas A; Martin, Laurent F; Smith, Brian J; Madsen, Kenneth L; Jensen, Knud J; Patwardhan, Amol; Safavi-Hemami, Helena

Genetic editing of primary human dorsal root ganglion neurons using CRISPR-Cas9.

利用 CRISPR-Cas9 对人类原代背根神经节神经元进行基因编辑

Palomino Seph M, Gabriel Katherin A, Mwirigi Juliet M, Cervantes Anna, Horton Peter, Funk Geoffrey, Moutal Aubin, Martin Laurent F, Khanna Rajesh, Price Theodore J, Patwardhan Amol

Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder

全基因组分析确定了30个与强迫症相关的基因位点

Strom, Nora I; Gerring, Zachary F; Galimberti, Marco; Yu, Dongmei; Halvorsen, Matthew W; Abdellaoui, Abdel; Rodriguez-Fontenla, Cristina; Sealock, Julia M; Bigdeli, Tim; Coleman, Jonathan R; Mahjani, Behrang; Thorp, Jackson G; Bey, Katharina; Burton, Christie L; Luykx, Jurjen J; Zai, Gwyneth; Alemany, Silvia; Andre, Christine; Askland, Kathleen D; Bäckmann, Julia; Banaj, Nerisa; Barlassina, Cristina; Nissen, Judith Becker; Bienvenu, O Joseph; Black, Donald; Bloch, Michael H; Børte, Sigrid; Bosch, Rosa; Breen, Michael; Brennan, Brian P; Brentani, Helena; Buxbaum, Joseph D; Bybjerg-Grauholm, Jonas; Byrne, Enda M; Cabana-Dominguez, Judit; Camarena, Beatriz; Camarena, Adrian; Cappi, Carolina; Carracedo, Angel; Casas, Miguel; Cavallini, Maria Cristina; Ciullo, Valentina; Cook, Edwin H; Crosby, Jesse; Cullen, Bernadette A; De Schipper, Elles J; Delorme, Richard; Djurovic, Srdjan; Elias, Jason A; Estivill, Xavier; Falkenstein, Martha J; Fundin, Bengt T; Garner, Lauryn; Gironda, Christina; Goes, Fernando S; Grados, Marco A; Grove, Jakob; Guo, Wei; Haavik, Jan; Hagen, Kristen; Harrington, Kelly; Havdahl, Alexandra; Höffler, Kira D; Hounie, Ana G; Hucks, Donald; Hultman, Christina; Janecka, Magdalena; Jenike, Eric; Karlsson, Elinor K; Kelley, Kara; Klawohn, Julia; Krasnow, Janice E; Krebs, Kristi; Lange, Christoph; Lanzagorta, Nuria; Levey, Daniel; Lindblad-Toh, Kerstin; Macciardi, Fabio; Maher, Brion; Mathes, Brittany; McArthur, Evonne; McGregor, Nathaniel; McLaughlin, Nicole C; Meier, Sandra; Miguel, Euripedes C; Mulhern, Maureen; Nestadt, Paul S; Nurmi, Erika L; O'Connell, Kevin S; Osiecki, Lisa; Ousdal, Olga Therese; Palviainen, Teemu; Pedersen, Nancy L; Piras, Fabrizio; Piras, Federica; Potluri, Sriramya; Rabionet, Raquel; Ramirez, Alfredo; Rauch, Scott; Reichenberg, Abraham; Riddle, Mark A; Ripke, Stephan; Rosário, Maria C; Sampaio, Aline S; Schiele, Miriam A; Skogholt, Anne Heidi; Sloofman, Laura G; Smit, Jan; Soler Artigas, María; Thomas, Laurent F; Tifft, Eric; Vallada, Homero; van Kirk, Nathanial; Veenstra-VanderWeele, Jeremy; Vulink, Nienke N; Walker, Christopher P; Wang, Ying; Wendland, Jens R; Winsvold, Bendik S; Yao, Yin; Zhou, Hang; Agrawal, Arpana; Alonso, Pino; Berberich, Götz; Bucholz, Kathleen K; Bulik, Cynthia M; Cath, Danielle; Denys, Damiaan; Eapen, Valsamma; Edenberg, Howard; Falkai, Peter; Fernandez, Thomas V; Fyer, Abby J; Gaziano, J M; Geller, Dan A; Grabe, Hans J; Greenberg, Benjamin D; Hanna, Gregory L; Hickie, Ian B; Hougaard, David M; Kathmann, Norbert; Kennedy, James; Lai, Dongbing; Landén, Mikael; Le Hellard, Stéphanie; Leboyer, Marion; Lochner, Christine; McCracken, James T; Medland, Sarah E; Mortensen, Preben B; Neale, Benjamin M; Nicolini, Humberto; Nordentoft, Merete; Pato, Michele; Pato, Carlos; Pauls, David L; Piacentini, John; Pittenger, Christopher; Posthuma, Danielle; Ramos-Quiroga, Josep Antoni; Rasmussen, Steven A; Richter, Margaret A; Rosenberg, David R; Ruhrmann, Stephan; Samuels, Jack F; Sandin, Sven; Sandor, Paul; Spalletta, Gianfranco; Stein, Dan J; Stewart, S Evelyn; Storch, Eric A; Stranger, Barbara E; Turiel, Maurizio; Werge, Thomas; Andreassen, Ole A; Børglum, Anders D; Walitza, Susanne; Hveem, Kristian; Hansen, Bjarne K; Rück, Christian; Martin, Nicholas G; Milani, Lili; Mors, Ole; Reichborn-Kjennerud, Ted; Ribasés, Marta; Kvale, Gerd; Mataix-Cols, David; Domschke, Katharina; Grünblatt, Edna; Wagner, Michael; Zwart, John-Anker; Breen, Gerome; Nestadt, Gerald; Kaprio, Jaakko; Arnold, Paul D; Grice, Dorothy E; Knowles, James A; Ask, Helga; Verweij, Karin J; Davis, Lea K; Smit, Dirk J; Crowley, James J; Scharf, Jeremiah M; Stein, Murray B; Gelernter, Joel; Mathews, Carol A; Derks, Eske M; Mattheisen, Manuel