日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Study of the antimalarial activity of 4-aminoquinoline compounds against chloroquine-sensitive and chloroquine-resistant parasite strains

研究4-氨基喹啉类化合物对氯喹敏感和氯喹耐药疟原虫株的抗疟活性

Lawrenson, Alexandre S; Cooper, David L; O'Neill, Paul M; Berry, Neil G

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria.

开发针对恶性疟原虫线粒体呼吸链的喹诺酮类抗疟药,用于治疗和预防疟疾

Biagini Giancarlo A, Fisher Nicholas, Shone Alison E, Mubaraki Murad A, Srivastava Abhishek, Hill Alisdair, Antoine Thomas, Warman Ashley J, Davies Jill, Pidathala Chandrakala, Amewu Richard K, Leung Suet C, Sharma Raman, Gibbons Peter, Hong David W, Pacorel Bénédicte, Lawrenson Alexandre S, Charoensutthivarakul Sitthivut, Taylor Lee, Berger Olivier, Mbekeani Alison, Stocks Paul A, Nixon Gemma L, Chadwick James, Hemingway Janet, Delves Michael J, Sinden Robert E, Zeeman Anne-Marie, Kocken Clemens H M, Berry Neil G, O'Neill Paul M, Ward Stephen A

Identification of novel antimalarial chemotypes via chemoinformatic compound selection methods for a high-throughput screening program against the novel malarial target, PfNDH2: increasing hit rate via virtual screening methods.

通过化学信息学化合物选择方法鉴定新型抗疟疾化学类型,用于针对新型疟疾靶点 PfNDH2 的高通量筛选程序:通过虚拟筛选方法提高命中率

Sharma Raman, Lawrenson Alexandre S, Fisher Nicholas E, Warman Ashley J, Shone Alison E, Hill Alasdair, Mbekeani Alison, Pidathala Chandrakala, Amewu Richard K, Leung Suet, Gibbons Peter, Hong David W, Stocks Paul, Nixon Gemma L, Chadwick James, Shearer Joanne, Gowers Ian, Cronk David, Parel Serge P, O'Neill Paul M, Ward Stephen A, Biagini Giancarlo A, Berry Neil G

HDQ, a potent inhibitor of Plasmodium falciparum proliferation, binds to the quinone reduction site of the cytochrome bc1 complex.

HDQ 是一种强效的恶性疟原虫增殖抑制剂,它与细胞色素 bc1 复合物的醌还原位点结合

Vallières Cindy, Fisher Nicholas, Antoine Thomas, Al-Helal Mohammed, Stocks Paul, Berry Neil G, Lawrenson Alexandre S, Ward Stephen A, O'Neill Paul M, Biagini Giancarlo A, Meunier Brigitte

Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression.

疟原虫细胞色素 b 突变 Y268S 赋予疟原虫阿托伐醌抗性表型,导致寄生虫 bc1 催化周转和蛋白质表达降低

Fisher Nicholas, Abd Majid Roslaini, Antoine Thomas, Al-Helal Mohammed, Warman Ashley J, Johnson David J, Lawrenson Alexandre S, Ranson Hilary, O'Neill Paul M, Ward Stephen A, Biagini Giancarlo A