A pharmacophore derived phenytoin analogue with increased affinity for slow inactivated sodium channels exhibits a desired anticonvulsant profile.
一种源自苯妥英钠的药效团类似物,对缓慢失活的钠通道具有更高的亲和力,表现出理想的抗惊厥特性
期刊:Neuropharmacology
影响因子:4.6
doi:10.1016/j.neuropharm.2006.11.001
Lenkowski Paul W, Batts Timothy W, Smith Misty D, Ko Seong-Hoon, Jones Paulianda J, Taylor Catherine H, McCusker Ashley K, Davis Gary C, Hartmann Hali A, White H Steve, Brown Milton L, Patel Manoj K