日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Deep mutational learning for the selection of therapeutic antibodies resistant to the evolution of Omicron variants of SARS-CoV-2

利用深度突变学习筛选对SARS-CoV-2 Omicron变异株进化具有抵抗力的治疗性抗体

Lester Frei # ,Beichen Gao # ,Jiami Han ,Joseph M Taft ,Edward B Irvine ,Cédric R Weber ,Rachita K Kumar ,Benedikt N Eisinger ,Andrey Ignatov ,Zhouya Yang ,Sai T Reddy

Deep mutational learning predicts ACE2 binding and antibody escape to combinatorial mutations in the SARS-CoV-2 receptor-binding domain

深度突变学习预测 SARS-CoV-2 受体结合域中组合突变导致的 ACE2 结合和抗体逃逸。

Joseph M Taft ,Cédric R Weber ,Beichen Gao ,Roy A Ehling ,Jiami Han ,Lester Frei ,Sean W Metcalfe ,Max D Overath ,Alexander Yermanos ,William Kelton ,Sai T Reddy

Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity

小鼠感染和自身免疫模型中 B 细胞和 T 细胞的单细胞免疫组库测序

Danielle Shlesinger, Kai-Lin Hong, Ghazal Shammas, Nicolas Page, Ioana Sandu, Andreas Agrafiotis, Victor Kreiner, Nicolas Fonta, Ilena Vincenti, Ingrid Wagner, Margot Piccinno, Alexandre Mariotte, Bogna Klimek, Raphael Dizerens, Marcos Manero-Carranza, Raphael Kuhn, Roy Ehling, Lester Frei, Keywan K