日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Systematic evaluation of single-cell multimodal data integration enhances cell type resolution and discovery of clinically relevant states in complex tissues

对单细胞多模态数据整合进行系统性评估,可提高细胞类型分辨率,并有助于发现复杂组织中具有临床意义的状态。

Acera-Mateos, Mario; Adiconis, Xian; Li, Jessica-Kanglin; Marchese, Domenica; Caratù, Ginevra; Hon, Chung-Chau; Tiwari, Prabha; Kojima, Miki; Vieth, Beate; Murphy, Michael A; Simmons, Sean K; Lefevre, Thomas; Claes, Irene; O'Connor, Christopher L; Menon, Rajasree; Otto, Edgar A; Ando, Yoshinari; Vandereyken, Katy; Kretzler, Matthias; Bitzer, Markus; Fraenkel, Ernest; Voet, Thierry; Enard, Wolfgang; Carninci, Piero; Heyn, Holger; Levin, Joshua Z; Mereu, Elisabetta

Aberrant mRNA splicing and impaired hippocampal neurogenesis in Grin2b mutant mice.

Grin2b突变小鼠出现异常mRNA剪接和海马神经发生受损。

Farsi Zohreh, Nicolella Ally, Simmons Sean K, Shin Wangyong, Kang Muwon, Lee Gina, Kwon Min Jee, Brenner Kira S, Picard Ines, Shepard Nate, Misri Deeksha, Perzel Mandell Kira A, Levin Joshua Z, Kim Eunjoon, Sheng Morgan

Concordant transcriptional and morphological remodeling revealed by in vivo Perturb-CLEAR

体内 Perturb-CLEAR 实验揭示了转录和形态重塑的一致性

Wu, Boli; Simmons, Sean K; Kim, Seoyeon; Li, Jiwen; Akram, Masood A; Park, Chang Sin; Zheng, Xinhe; Mendez, Iain; Patel, Sasha; Chau, Alan; Burciu, Nadia; Dayal, Pranay; Nyasulu, Thokozile; Huynh, Nhan; Clarke, Grace S; Yang, X William; Levin, Joshua Z; Jin, Xin

In vivo multiomic Perturb-seq with enhanced nuclear gRNA capture

利用增强的核gRNA捕获技术进行体内多组学Perturb-seq测序

Zheng, Xinhe; Li, Jiwen; Kim, Kwanho; Simmons, Sean K; Zhao, Ziyan; Tastemel, Melodi; Huynh, Nhan; Qiu, Huixian; Ye, Juntong; White, Cassandra M; Levin, Joshua Z; Jin, Xin

Integrating Long-Read Structural Variant Analysis with single-nucleus RNA-seq to Elucidate Gene Expression Effects in Disease

将长读长结构变异分析与单核RNA测序相结合,以阐明疾病中的基因表达效应。

Kim, Kwanho; Lin, Zechuan; Simmons, Sean K; Parker, Jacob; Kearney, Matthew; Liao, Zhixiang; Haywood, Nathan; Zhang, Jixiang; Cline, Madison P; Tuncali, Idil; Sharma, Monika; Serrano, Geidy E; Beach, Thomas G; Dong, Xianjun; Popic, Victoria; Scherzer, Clemens R; Levin, Joshua Z

Author Correction: Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types

作者更正:异时共生通过改变多种细胞类型中的衰老特征来重编程小鼠大脑转录组

Ximerakis, Methodios; Holton, Kristina M; Giadone, Richard M; Ozek, Ceren; Saxena, Monika; Santiago, Samara; Adiconis, Xian; Dionne, Danielle; Nguyen, Lan; Shah, Kavya M; Goldstein, Jill M; Gasperini, Caterina; Gampierakis, Ioannis A; Lipnick, Scott L; Simmons, Sean K; Buchanan, Sean M; Wagers, Amy J; Regev, Aviv; Levin, Joshua Z; Rubin, Lee L

Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus

对多种精神分裂症基因小鼠模型的大脑转录组进行荟萃分析,结果显示纹状体和丘脑存在功能失调。

Perzel Mandell, Kira A; Simmons, Sean K; Nadig, Ajay; Farsi, Zohreh; Huang, Wei-Chao; Aryal, Sameer; Kwon, Min Jee; Song, Bryan; Brenner, Kira; Shepard, Nate; Nicolella, Ally A; O'Brien, Lesley D; Lichtman, Aron H; Levin, Joshua Z; Sheng, Morgan

A foundational neuronal protein network model unifying multimodal genetic, transcriptional, and proteomic perturbations in schizophrenia

一个基础性的神经元蛋白网络模型,统一了精神分裂症中多模态的遗传、转录和蛋白质组扰动

Pintacuda, Greta; Hsu, Yu-Han H; Páleníková, Petra; Dubonyte, Ugne; Fornelos, Nadine; Chen, Miao; Mena, Daya; Biagini, Julia C; Botts, Travis; Martorana, Makayla; Rebelo, Danzel; Ching, Joshua K T; Crouse, Ethan; Gebre, Hilena; Adiconis, Xian; Haywood, Nathan; Simmons, Sean; Weïwer, Michel; Hawes, Derek; Pietilainen, Olli; Werge, Thomas; Li, Ka Wan; Smit, August B; Kirkeby, Agnete; Levin, Joshua Z; Nehme, Ralda; Lage, Kasper

Human brain organoids record the passage of time over multiple years in culture

人类脑类器官记录了培养多年期间的时间流逝

Faravelli, Irene; Antón-Bolaños, Noelia; Wei, Anqi; Faits, Tyler; Sampath Kumar, Abhishek; Andreadis, Sophia; Kastli, Rahel; Montero Crespo, Marta; Steiger, Mara; Leible, Daniel; Zhang, Elizabeth; An, Bobae; Meirovitch, Yaron; Silwal, Sayara; Yang, Sung Min; Kovacsovics, Alexander; Adiconis, Xian; Kretzmer, Helene; Levin, Joshua Z; Boyden, Edward S; Lichtman, Jeff; Regev, Aviv; Meissner, Alexander; Arlotta, Paola

Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder.

Akap11 突变小鼠(一种精神分裂症和双相情感障碍的遗传模型)中突触 PKA 活性升高和纹状体多巴胺信号异常。

Song Bryan J, Ge Yang, Nicolella Ally, Kwon Min Jee, Lodder Bart, Bonanno Kevin, Valle-Tojeiro Antia, Hartley Nolan D, Mandell Kira Perzel, Adeleye John, Misri Deeksha, Geng Chuhan, Natarajan Sahana, Picard Inès, Shepard Nate, Hall Alyssa, Tian Jiawen, Aryal Sameer, Farsi Zohreh, Liu Xiao-Man, Morshed Nader, Nadaf Naeem M, Pribiag Horia, Simmons Sean K, Mani D R, Stevens Beth, Kunwar Prabhat S, Fu Zhanyan, Macosko Evan Z, Levin Joshua Z, Sabatini Bernardo L, Carr Steven A, Dejanovic Borislav, Keshishian Hasmik, Granger Adam J, Sheng Morgan