日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression

促进凝聚的 ENL 突变通过动态调节组蛋白修饰和基因表达来驱动体内肿瘤形成

Yiman Liu #, Qinglan Li #, Lele Song, Chujie Gong, Sylvia Tang, Krista A Budinich, Ashley Vanderbeck, Kaeli M Mathias, Gerald B Wertheim, Son C Nguyen, Riley Outen, Eric F Joyce, Ivan Maillard, Liling Wan

Single-cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape

单细胞多组学揭示 ENL 突变通过重新连接基因调控环境扰乱肾脏发育轨迹

Lele Song #, Qinglan Li #, Lingbo Xia, Arushi Eesha Sahay, Qi Qiu, Yuanyuan Li, Haitao Li, Kotaro Sasaki, Katalin Susztak, Hao Wu, Liling Wan

Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia

突变的 NPM1 劫持转录中心以维持急性髓系白血病中的致病基因程序

Xue Qing David Wang #, Dandan Fan #, Qinyu Han #, Yiman Liu #, Hongzhi Miao, Xinyu Wang, Qinglan Li, Dong Chen, Haley Gore, Pamela Himadewi, Gerd P Pfeifer, Tomasz Cierpicki, Jolanta Grembecka, Jianzhong Su #, Shasha Chong #, Liling Wan #, Xiaotian Zhang #

DLBCL-associated NOTCH2 mutations escape ubiquitin-dependent degradation and promote chemoresistance

DLBCL相关的NOTCH2突变可逃避泛素依赖性降解并促进化疗耐药性

Nan Zhou ,Jaewoo Choi ,Grant Grothusen ,Bang-Jin Kim ,Diqiu Ren ,Zhendong Cao ,Yiman Liu ,Qinglan Li ,Arati Inamdar ,Thomas Beer ,Hsin-Yao Tang ,Eric Perkey ,Ivan Maillard ,Roberto Bonasio ,Junwei Shi ,Marco Ruella ,Liling Wan ,Luca Busino

p53 restoration in small cell lung cancer identifies a latent cyclophilin-dependent necrosis mechanism

小细胞肺癌中 p53 的恢复揭示了一种潜在的环孢素依赖性坏死机制

Jonuelle Acosta ,Qinglan Li ,Nelson F Freeburg ,Nivitha Murali ,Alexandra Indeglia ,Grant P Grothusen ,Michelle Cicchini ,Hung Mai ,Amy C Gladstein ,Keren M Adler ,Katherine R Doerig ,Jinyang Li ,Miguel Ruiz-Torres ,Kimberly L Manning ,Ben Z Stanger ,Luca Busino ,Maureen Murphy ,Liling Wan ,David M Feldser

Different cell compositions and a novel somatic KCNJ5 variant found in a patient with bilateral adrenocortical adenomas secreting aldosterone and cortisol

在一名患有双侧肾上腺皮质腺瘤(分泌醛固酮和皮质醇)的患者中,发现了不同的细胞组成和一种新的体细胞KCNJ5变异体。

Zhao, Liling; Wan, Jinjing; Wang, Yujun; Yang, Wenjun; Liang, Qi; Wang, Jinrong; Jin, Ping

Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia

以小分子抑制剂抑制酰基赖氨酸阅读器ENL作为对抗急性髓系白血病的策略

Yiman Liu ,Qinglan Li ,Fatemeh Alikarami ,Declan R Barrett ,Leila Mahdavi ,Hangpeng Li ,Sylvia Tang ,Tanweer A Khan ,Mayako Michino ,Connor Hill ,Lele Song ,Lu Yang ,Yuanyuan Li ,Sheela Pangeni Pokharel ,Andrew W Stamford ,Nigel Liverton ,Louis M Renzetti ,Simon Taylor ,Gillian F Watt ,Tammy Ladduwahetty ,Stacia Kargman ,Peter T Meinke ,Michael A Foley ,Junwei Shi ,Haitao Li ,Martin Carroll ,Chun-Wei Chen ,Alessandro Gardini ,Ivan Maillard ,David J Huggins ,Kathrin M Bernt ,Liling Wan

KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs

KAT6A和ENL形成表观遗传转录控制模块,驱动关键的白血病基因表达程序

Fangxue Yan # ,Jinyang Li # ,Jelena Milosevic # ,Ricardo Petroni ,Suying Liu ,Zhennan Shi ,Salina Yuan ,Janice M Reynaga ,Yuwei Qi ,Joshua Rico ,Sixiang Yu ,Yiman Liu ,Susumu Rokudai ,Neil Palmisiano ,Sara E Meyer ,Pamela J Sung ,Liling Wan ,Fei Lan ,Benjamin A Garcia ,Ben Z Stanger ,David B Sykes ,M Andrés Blanco

Pharmacological disruption of the MTDH-SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer

MTDH-SND1复合物的药理学破坏可增强肿瘤抗原呈递,并与转移性乳腺癌中的抗PD-1疗法产生协同作用。

Minhong Shen ,Heath A Smith ,Yong Wei ,Yi-Zhou Jiang ,Sheng Zhao ,Nicole Wang ,Michelle Rowicki ,Yong Tang ,Xiang Hang ,Songyang Wu ,Liling Wan ,Zhi-Ming Shao ,Yibin Kang

Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis

破坏 MTDH-SND1 复合物的小分子抑制剂可抑制乳腺癌进展和转移

Minhong Shen, Yong Wei, Hahn Kim, Liling Wan, Yi-Zhou Jiang, Xiang Hang, Michael Raba, Stacy Remiszewski, Michelle Rowicki, Cheng-Guo Wu, Songyang Wu, Lanjing Zhang, Xin Lu, Min Yuan, Heath A Smith, Aiping Zheng, Joseph Bertino, John F Jin, Yongna Xing, Zhi-Ming Shao, Yibin Kang