日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Detection of host cell microprotein impurities in antibody drug products

抗体药物产品中宿主细胞微生物蛋白杂质的检测

Ioanna Tzani #, Marina Castro-Rivadeneyra #, Paul Kelly, Lisa Strasser, Lin Zhang, Martin Clynes, Barry L Karger, Niall Barron, Jonathan Bones #, Colin Clarke #

A Direct Comparison of rAAV5 Variants Derived from the Baculovirus Expression System Using LC-MS Workflows Demonstrates Key Differences in Overall Production Yield, Product Quality and Vector Efficiency

使用 LC-MS 工作流程直接比较杆状病毒表达系统衍生的 rAAV5 变体,展现出总体产量、产品质量和载体效率方面的关键差异

Felipe Guapo, Nicholas Donohue, Lisa Strasser, Stefano Boi, Florian Füssl, Alana Rainbow-Fletcher, Paul Getty, Ian Anderson, Niall Barron, Jonathan Bones

Whole-cell energy modeling reveals quantitative changes of predicted energy flows in RAS mutant cancer cell lines

全细胞能量模型揭示 RAS 突变癌细胞系中预测能量流的定量变化

Thomas Sevrin, Lisa Strasser, Camille Ternet, Philipp Junk, Miriam Caffarini, Stella Prins, Cian D'Arcy, Simona Catozzi, Giorgio Oliviero, Kieran Wynne, Christina Kiel, Philip J Luthert

Development of a Rapid Adeno-Associated Virus (AAV) Identity Testing Platform through Comprehensive Intact Mass Analysis of Full-Length AAV Capsid Proteins

通过对全长 AAV 衣壳蛋白进行全面完整质量分析,开发快速腺相关病毒 (AAV) 身份检测平台

Josh Smith, Felipe Guapo, Lisa Strasser, Silvia Millán-Martín, Steven G Milian, Richard O Snyder, Jonathan Bones

CAR Gene Delivery by T-cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms

雷帕霉素诱导的抗病毒机制减弱增强了 T 细胞靶向慢病毒载体的 CAR 基因传递

Filippos T Charitidis, Elham Adabi, Naphang Ho, Angela H Braun, Ciara Tierney, Lisa Strasser, Frederic B Thalheimer, Liam Childs, Jonathan Bones, Colin Clarke, Christian J Buchholz

Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS

使用自动化样品制备和数据独立采集 LC-MS/MS 检测和定量单克隆抗体药物产品中的宿主细胞蛋白

Lisa Strasser, Giorgio Oliviero, Craig Jakes, Izabela Zaborowska, Patrick Floris, Meire Ribeiro da Silva, Florian Füssl, Sara Carillo, Jonathan Bones

Proteomic Profiling of IgG1 Producing CHO Cells Using LC/LC-SPS-MS3: The Effects of Bioprocessing Conditions on Productivity and Product Quality

使用 LC/LC-SPS-MS3 对产生 IgG1 的 CHO 细胞进行蛋白质组学分析:生物加工条件对生产力和产品质量的影响

Lisa Strasser, Amy Farrell, Jenny T C Ho, Kai Scheffler, Ken Cook, Patrick Pankert, Peter Mowlds, Rosa Viner, Barry L Karger, Jonathan Bones

Proteomic Landscape of Adeno-Associated Virus (AAV)-Producing HEK293 Cells

腺相关病毒 (AAV) 产生 HEK293 细胞的蛋白质组学景观

Lisa Strasser, Stefano Boi, Felipe Guapo, Nicholas Donohue, Niall Barron, Alana Rainbow-Fletcher, Jonathan Bones

In silico Design of Phl p 6 Variants With Altered Fold-Stability Significantly Impacts Antigen Processing, Immunogenicity and Immune Polarization

计算机模拟设计具有改变折叠稳定性的 Phl p 6 变体会显著影响抗原加工、免疫原性和免疫极化

Petra Winter, Stefan Stubenvoll, Sandra Scheiblhofer, Isabella A Joubert, Lisa Strasser, Carolin Briganser, Wai Tuck Soh, Florian Hofer, Anna Sophia Kamenik, Valentin Dietrich, Sara Michelini, Josef Laimer, Peter Lackner, Jutta Horejs-Hoeck, Martin Tollinger, Klaus R Liedl, Johann Brandstetter, Chri

Platform independent protein-based cell-of-origin subtyping of diffuse large B-cell lymphoma in formalin-fixed paraffin-embedded tissue

福尔马林固定石蜡包埋组织中弥漫大 B 细胞淋巴瘤的基于平台的蛋白质细胞来源亚型分析

Jörg Reinders #, Michael Altenbuchinger #, Katharina Limm, Philipp Schwarzfischer, Tamara Scheidt, Lisa Strasser, Julia Richter, Monika Szczepanowski, Christian G Huber, Wolfram Klapper, Rainer Spang, Peter J Oefner